Publications by authors named "Adrian D Hobson"

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Fluorogenic Platform for Real-Time Imaging of Subcellular Payload Release in Antibody-Drug Conjugates.
Ferran Nadal-Bufi, Paulin L Salomon, Fabio de Moliner, Kathy A Sarris, Zhi Wang, Adrian D Hobson

J Am Chem Soc· March 2025

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Impact of atropisomerism on a non-steroidal glucocorticoid receptor agonist.
Zhou Xu, Zhongyuan Wang, Xiaona Shi, Rui Ding, Li Han, Adrian D Hobson

RSC Med Chem· July 2024

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Impact of drug-linker on method selection for analytical characterization and purification of antibody-drug conjugates.
Ling C Santora, Adrian D Hobson, Lu Wang, Kan X Wu

Anal Methods· June 2024

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Anti-TNF Thioester Glucocorticoid Antibody-Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model.
Christopher C Marvin, Adrian D Hobson, Michael J McPherson, Martin E Hayes, Meena V Patel

J Med Chem· June 2024

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An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases.
Michael J McPherson, Adrian D Hobson, Axel Hernandez, Christopher C Marvin, Wendy Waegell

Sci Transl Med· March 2024

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Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties.
Adrian D Hobson, Haizhong Zhu, Wei Qiu, Russell A Judge, Kenton Longenecker

RSC Med Chem· March 2024

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The medicinal chemistry evolution of antibody-drug conjugates.
Adrian D Hobson

RSC Med Chem· March 2024

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Correction: Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties.
Adrian D Hobson, Haizhong Zhu, Wei Qiu, Russell A Judge, Kenton Longenecker

RSC Med Chem· March 2024

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Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates.
Lu Wang, Adrian D Hobson, Paulin L Salomon, Julia Fitzgibbons, Jianwen Xu

RSC Med Chem· February 2024

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Impact of dipeptide on ADC physicochemical properties and efficacy identifies Ala-Ala as the optimal dipeptide.
Lu Wang, Adrian D Hobson, Julia Fitzgibbons, Axel Hernandez, Ying Jia

RSC Med Chem· January 2024

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Antibody drug conjugates beyond cytotoxic payloads.
Adrian D Hobson

Prog Med Chem· November 2023

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Self-Immolative Carbamate Linkers for CD19-Budesonide Antibody-Drug Conjugates.
Christopher C Marvin, Adrian D Hobson, Michael McPherson, Theresa A Dunstan, Thomas R Vargo

Bioconjug Chem· October 2023

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Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC).
Adrian D Hobson, Jianwen Xu, Dennie S Welch, Christopher C Marvin, Michael J McPherson

J Med Chem· September 2023

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Optimization of Drug-Linker to Enable Long-term Storage of Antibody-Drug Conjugate for Subcutaneous Dosing.
Adrian D Hobson, Jianwen Xu, Christopher C Marvin, Michael J McPherson, Markus Hollmann

J Med Chem· July 2023

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Correction to "Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate".
Adrian D Hobson, Michael J McPherson, Martin E Hayes, Christian Goess, Xiang Li

J Med Chem· April 2023

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Correction to "Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody-Drug Conjugate Payloads".
Adrian D Hobson, Michael J McPherson, Wendy Waegell, Christian A Goess, Robert H Stoffel

J Med Chem· April 2023

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Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate.
Adrian D Hobson, Michael J McPherson, Martin E Hayes, Christian Goess, Xiang Li

J Med Chem· December 2022

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Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody-Drug Conjugate Payloads.
Adrian D Hobson, Michael J McPherson, Wendy Waegell, Christian A Goess, Robert H Stoffel

J Med Chem· March 2022

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Pushing the Envelope: Advancement of ADCs Outside of Oncology.
Michael J McPherson, Adrian D Hobson

Methods Mol Biol· January 2021

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Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.
Justin D Dietrich, Kenton L Longenecker, Noel S Wilson, Christian Goess, Sanjay C Panchal, Adrian D Hobson

J Med Chem· January 2021

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Covalent binders in drug discovery.
Anil Vasudevan, Maria A Argiriadi, Aleksandra Baranczak, Michael M Friedman, Julia Gavrilyuk, Adrian D Hobson

Prog Med Chem· March 2019

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Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design.
Adrian D Hobson, Russell A Judge, Ana L Aguirre, Brian S Brown, Yifang Cui

J Med Chem· December 2018

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Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate.
Russell A Judge, Anil Vasudevan, Victoria E Scott, Gricelda H Simler, Steve D Pratt, Adrian D Hobson

Chembiochem· March 2018

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Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders.
Adrian D Hobson, Christopher M Harris, Elizabeth L van der Kam, Sean C Turner, Ayome Abibi

J Med Chem· December 2015

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Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol.
Eric R Goedken, Maria A Argiriadi, David L Banach, Bryan A Fiamengo, Sage E Foley, Adrian D Hobson

J Biol Chem· February 2015

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