Publications by authors named "Russell A Judge"

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Discovery of Orally Efficacious Bridged Piperazines as smTNF Modulators.
Zhiguo Bian, Robert G Schmidt, Noel S Wilson, David B Duignan, Eric Breinlinger, Russell A Judge

J Med Chem· July 2025

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BCL-X-targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors.
Andrew S Judd, Bhupinder Bawa, Wayne R Buck, Zhi-Fu Tao, Yingchun Li, Russell A Judge

Sci Adv· October 2024

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Inhibition of MALT1 and BCL2 Induces Synergistic Antitumor Activity in Models of B-Cell Lymphoma.
Joshua P Plotnik, Adam E Richardson, Haopeng Yang, Estela Rojas, Velitchka Bontcheva, Russell A Judge

Mol Cancer Ther· July 2024

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Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties.
Adrian D Hobson, Haizhong Zhu, Wei Qiu, Russell A Judge, Kenton Longenecker

RSC Med Chem· March 2024

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Correction: Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties.
Adrian D Hobson, Haizhong Zhu, Wei Qiu, Russell A Judge, Kenton Longenecker

RSC Med Chem· March 2024

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Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients.
Junichiro Yuda, Christine Will, Darren C Phillips, Linu Abraham, Cory Alvey, Russell A Judge

Commun Med (Lond)· October 2023

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Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition.
Janani Sridar, Amirhossein Mafi, Russell A Judge, Jun Xu, Kailyn A Kong

Commun Chem· October 2023

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Structure of the PAPP-A complex reveals mechanism of substrate recognition.
Russell A Judge, Janani Sridar, Kathryn Tunyasuvunakool, Rinku Jain, John C K Wang

Nat Commun· September 2022

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Author Correction: Structure of the PAPP-A complex reveals mechanism of substrate recognition.
Russell A Judge, Janani Sridar, Kathryn Tunyasuvunakool, Rinku Jain, John C K Wang

Nat Commun· September 2022

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Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Eric R Goedken, Maria A Argiriadi, Justin D Dietrich, Andrew M Petros, Navasona Krishnan, Russell A Judge

Sci Rep· August 2022

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An anti-PD-1-GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy.
Sarah Chan, Nicole Belmar, Sun Ho, Bryan Rogers, Marcia Stickler, Russell A Judge

Nat Cancer· March 2022

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Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers.
Ahmed Hamed Salem, Zhi-Fu Tao, Orlando F Bueno, Jie Chen, Shuang Chen, Russell A Judge

Mol Cancer Ther· June 2021

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Structure-Based Design of A-1293102, a Potent and Selective BCL-X Inhibitor.
Zhi-Fu Tao, Xilu Wang, Jun Chen, Justin P Ingram, Sha Jin, Russell A Judge

ACS Med Chem Lett· June 2021

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Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-X Inhibitor.
Le Wang, George A Doherty, Andrew S Judd, Zhi-Fu Tao, T Matthew Hansen, Russell A Judge

ACS Med Chem Lett· October 2020

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CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches.
Maria A Argiriadi, Lorenzo Benatuil, Ievgeniia Dubrovska, David A Egan, Lei Gao, Russell A Judge

BMC Mol Cell Biol· August 2019

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Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design.
Adrian D Hobson, Russell A Judge, Ana L Aguirre, Brian S Brown, Yifang Cui

J Med Chem· December 2018

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Targeting lysine specific demethylase 4A (KDM4A) tandem TUDOR domain - A fragment based approach.
Anup K Upadhyay, Russell A Judge, Leiming Li, Ron Pithawalla, Justin Simanis

Bioorg Med Chem Lett· June 2018

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Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate.
Russell A Judge, Anil Vasudevan, Victoria E Scott, Gricelda H Simler, Steve D Pratt

Chembiochem· March 2018

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Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8.
Russell A Judge, Haizhong Zhu, Anup K Upadhyay, Pierre M Bodelle, Charles W Hutchins

ACS Med Chem Lett· December 2016

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Creation of a S1P Lyase bacterial surrogate for structure-based drug design.
Maria A Argiriadi, David Banach, Elzbieta Radziejewska, Susan Marchie, Jennifer DiMauro, Russell A Judge

Bioorg Med Chem Lett· May 2016

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Three-dimensional structure, binding, and spectroscopic characteristics of the monoclonal antibody 43.1 directed to the carboxyphenyl moiety of fluorescein.
Susan Gayda, Kenton L Longenecker, Russell A Judge, Kerry M Swift, Sharmila Manoj

Biopolymers· April 2016

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Correction to Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity.
Milan Bruncko, Le Wang, George S Sheppard, Darren C Phillips, Stephen K Tahir, Russell A Judge

J Med Chem· May 2015

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Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.
Milan Bruncko, Le Wang, George S Sheppard, Darren C Phillips, Stephen K Tahir, Russell A Judge

J Med Chem· March 2015

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Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
Zhi-Fu Tao, Lisa Hasvold, Le Wang, Xilu Wang, Andrew M Petros, Russell A Judge

ACS Med Chem Lett· October 2014

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Water channel in the binding site of a high affinity anti-methotrexate antibody.
Susan Gayda, Kenton L Longenecker, Sharmila Manoj, Russell A Judge, Sylvia C Saldana

Biochemistry· June 2014

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