Publications by authors named "Adrian Highton"

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Gold-Mediated Multiple Cysteine Arylation for the Construction of Highly Constrained Bicycle Peptides.
Gemma E Mudd, Steven J Stanway, David R Witty, Alex Thomas, Silvia Baldo, Adrian Highton

Bioconjug Chem· August 2022

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Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice.
Iain W McNae, James Kinkead, Divya Malik, Li-Hsuan Yen, Martin K Walker, Adrian J Highton

Nat Commun· February 2021

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Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle.
Richard L Mackman, Victoria A Steadman, David K Dean, Petr Jansa, Karine G Poullennec, Adrian J Highton

J Med Chem· November 2018

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Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors.
James J Crawford, Peter W Kenny, Jonathan Bowyer, Calum R Cook, Jonathan E Finlayson, Adrian J Highton

J Med Chem· October 2012

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Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition.
Alexander G Dossetter, Jonathan Bowyer, Calum R Cook, James J Crawford, Jonathan E Finlayson, Adrian J Highton

Bioorg Med Chem Lett· September 2012

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(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis.
Alexander G Dossetter, Howard Beeley, Jonathan Bowyer, Calum R Cook, James J Crawford, Adrian J Highton

J Med Chem· July 2012

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Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis.
John G Cumming, Howard Tucker, John Oldfield, Colin Fielding, Adrian Highton

Bioorg Med Chem Lett· February 2012

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Synthesis of the asperparaline core by a radical cascade.
Peter J Crick, Nigel S Simpkins, Adrian Highton

Org Lett· December 2011

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A total synthesis of galbonolide B.
Philip J Parsons, Lewis Pennicott, James Eshelby, Matthias Goessman, Adrian Highton

J Org Chem· November 2007

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Model studies for the synthesis of galbonolide B.
James Eshelby, Matthias Goessman, Philip J Parsons, Lewis Pennicott, Adrian Highton

Org Biomol Chem· August 2005

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