Publications by authors named "Adrian Wiegmans"

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Current challenges in metastasis research and future innovation for clinical translation.
Amelia L Parker, Madeleine Benguigui, Jaime Fornetti, Erica Goddard, Serena Lucotti, Adrian P Wiegmans

Clin Exp Metastasis· April 2022

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Correction to 'Genome instability and pressure on non-homologous end joining drives chemotherapy resistance via a DNA repair crisis switch in triple negative breast cancer'.
Adrian P Wiegmans, Ambber Ward, Ekaterina Ivanova, Pascal H G Duijf, Mark N Adams

NAR Cancer· September 2021

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Genome instability and pressure on non-homologous end joining drives chemotherapy resistance via a DNA repair crisis switch in triple negative breast cancer.
Adrian P Wiegmans, Ambber Ward, Ekaterina Ivanova, Pascal H G Duijf, Mark N Adams

NAR Cancer· June 2021

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Circulating Tumor Cells in Metastatic Breast Cancer: From Genome Instability to Metastasis.
Ekaterina Ivanova, Ambber Ward, Adrian P Wiegmans, Derek John Richard

Front Mol Biosci· July 2020

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Identifying Therapies to Combat Epithelial Mesenchymal Plasticity-Associated Chemoresistance to Conventional Breast Cancer Therapies Using An shRNA Library Screen.
Sugandha Bhatia, Tony Blick, Cletus Pinto, Mark Waltham, James Monkman, Adrian P Wiegmans

Cancers (Basel)· April 2020

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Simultaneous targeting of DNA replication and homologous recombination in glioblastoma with a polyether ionophore.
Yi Chieh Lim, Kathleen S Ensbey, Carolin Offenhäuser, Rochelle C J D'souza, Jason K Cullen, Adrian P Wiegmans

Neuro Oncol· February 2020

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Breast Cancer-Derived Exosomes Alter Macrophage Polarization gp130/STAT3 Signaling.
Sunyoung Ham, Luize G Lima, Edna Pei Zhi Chai, Alexandra Muller, Richard J Lobb, Adrian P Wiegmans

Front Immunol· July 2019

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EGFR and Prion protein promote signaling via FOXO3a-KLF5 resulting in clinical resistance to platinum agents in colorectal cancer.
Caroline J Atkinson, Futoshi Kawamata, Cheng Liu, Sunyoung Ham, Balázs Győrffy, Adrian P Wiegmans

Mol Oncol· April 2019

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Secreted cellular prion protein binds doxorubicin and correlates with anthracycline resistance in breast cancer.
Adrian P Wiegmans, Jodi M Saunus, Sunyoung Ham, Richard Lobb, Jamie R Kutasovic

JCI Insight· February 2019

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Monitoring DNA Repair Consequences of ATM Signaling Using Simultaneous Fluorescent Readouts.
Adrian Wiegmans

Methods Mol Biol· February 2018

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Defects in recombination activity caused by somatic and germline mutations in the multimerization/BRCA2 binding region of human RAD51 protein.
Michelle C Silva, Katie E Bryan, Milagros D Morrical, April M Averill, Julie Dragon, Adrian P Wiegmans

DNA Repair (Amst)· December 2017

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Exosomes derived from mesenchymal non-small cell lung cancer cells promote chemoresistance.
Richard J Lobb, Rosa van Amerongen, Adrian Wiegmans, Sunyoung Ham, Jill E Larsen

Int J Cancer· August 2017

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Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage.
Joshua A Betts, Mahdi Moradi Marjaneh, Fares Al-Ejeh, Yi Chieh Lim, Wei Shi, Adrian P Wiegmans

Am J Hum Genet· August 2017

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Quinazolinone derivatives as inhibitors of homologous recombinase RAD51.
Ambber Ward, Lilong Dong, Jonathan M Harris, Kum Kum Khanna, Fares Al-Ejeh, Adrian P Wiegmans

Bioorg Med Chem Lett· July 2017

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Prion protein scrapie and the normal cellular prion protein.
Caroline J Atkinson, Kai Zhang, Alan L Munn, Adrian Wiegmans, Ming Q Wei

Prion· January 2017

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RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy.
Adrian P Wiegmans, Mariska Miranda, Shu Wen Wen, Fares Al-Ejeh, Andreas Möller

Oncotarget· September 2016

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Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib.
Darrell C Bessette, Erik Tilch, Tatjana Seidens, Michael C J Quinn, Adrian P Wiegmans

PLoS One· February 2016

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High content screening application for cell-type specific behaviour in heterogeneous primary breast epithelial subpopulations.
Rebecca L Johnston, Leesa Wockner, Amy E McCart Reed, Adrian Wiegmans, Georgia Chenevix-Trench

Breast Cancer Res· February 2016

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Differences in Expression of Key DNA Damage Repair Genes after Epigenetic-Induced BRCAness Dictate Synthetic Lethality with PARP1 Inhibition.
Adrian P Wiegmans, Pei-Yi Yap, Ambber Ward, Yi Chieh Lim, Kum Kum Khanna

Mol Cancer Ther· October 2015

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Optimized exosome isolation protocol for cell culture supernatant and human plasma.
Richard J Lobb, Melanie Becker, Shu Wen Wen, Christina S F Wong, Adrian P Wiegmans

J Extracell Vesicles· July 2015

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Targeting homologous recombination, new pre-clinical and clinical therapeutic combinations inhibiting RAD51.
Ambber Ward, Kum Kum Khanna, Adrian P Wiegmans

Cancer Treat Rev· January 2015

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Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer.
Fares Al-Ejeh, Mariska Miranda, Wei Shi, Peter T Simpson, Sarah Song, Adrian P Wiegmans

Oncotarget· May 2014

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Rad51 supports triple negative breast cancer metastasis.
Adrian P Wiegmans, Fares Al-Ejeh, Nicole Chee, Pei-Yi Yap, Julia J Gorski

Oncotarget· May 2014

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Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor.
Fares Al-Ejeh, Wei Shi, Mariska Miranda, Peter T Simpson, Ana Cristina Vargas, Adrian P Wiegmans

J Nucl Med· June 2013

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Deciphering the molecular events necessary for synergistic tumor cell apoptosis mediated by the histone deacetylase inhibitor vorinostat and the BH3 mimetic ABT-737.
Adrian P Wiegmans, Amber E Alsop, Michael Bots, Leonie A Cluse, Steven P Williams

Cancer Res· May 2011

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