Publications by authors named "Adrienne Edkins"

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New insights into Sti1/Hop's cochaperone function highlight the complexity of proteostatic regulation.
Gregory Lloyd Blatch, Adrienne Lesley Edkins

FEBS J· July 2025

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The novel amino-artemisinin derivative WHN-11 disrupts mitochondria and protein homeostasis, and induces autophagy and apoptosis in cancer cells.
Deborah Kajewole, Ho Ning Wong, Alexander von Kriegsheim, Richard K Haynes, Jo-Anne de la Mare, Adrienne Lesley Edkins

Sci Rep· July 2025

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Ferrocene thiazolidine-2,4-dione derivatives cause DNA damage and interfere with DNA repair in triple-negative breast cancer cells.
Nyeleti Vukea, Ogunyemi Oderinlo, Matshawandile Tukulula, Setshaba David Khanye, Adrienne Lesley Edkins

PLoS One· July 2025

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Genetic Variation in Drug Targets: Are We Ready for the Era of Precision Medicinal Chemistry?
Clinton G L Veale, Adrienne L Edkins

ACS Med Chem Lett· May 2025

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Exploring the Inhibitory Potential of Sodium Alginate Against Digestive Enzymes Linked to Obesity and Type 2 Diabetes.
Chantal D Daub, Arryn L Michaels, Blessing Mabate, Lithalethu Mkabayi, Adrienne L Edkins

Molecules· March 2025

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Modulators of the Hop-HSP90 Protein-Protein Interaction Disrupt KSHV Lytic Replication.
Michael O Okpara, Michaelone C Vaaltyn, Jessica L Watson, Mahama Alhassan, Fernando Albericio, Adrienne L Edkins

ACS Infect Dis· November 2024

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Hsp70-Hsp90 organising protein (HOP/STIP1) is required for KSHV lytic replication.
Elisa Kirigin, Michael Obinna Okpara, Lorraine Matandirotya, Jamie-Lee Ruck, Frederick Weaver, Adrienne Lesley Edkins

J Gen Virol· November 2024

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Discovery of a small-molecule inhibitor of KSHV lytic replication from the MMV pandemic response box.
Michael O Okpara, Frederick Weaver, Adrian Whitehouse, Clinton G L Veale, Adrienne L Edkins

Antiviral Res· October 2024

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Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity.
Gciniwe S Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P Akerman, Adrienne L Edkins

RSC Med Chem· September 2024

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In vitro evaluation of the application of an optimized xylanase cocktail for improved monogastric feed digestibility.
Lebogang Ramatsui, Tariro Sithole, Madhavi L Gandla, Leif J Jönsson, Adrienne L Edkins

J Anim Physiol Anim Nutr (Berl)· May 2024

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A native mass spectrometry approach to qualitatively elucidate interfacial epitopes of transient protein-protein interactions.
Clinton G L Veale, Abir Chakraborty, Richwell Mhlanga, Fernando Albericio, Beatriz G de la Torre, Adrienne L Edkins

Chem Commun (Camb)· May 2024

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Editorial: A new chapter for Cell Stress and Chaperones.
Dimitra Bourboulia, Laura J Blair, Melody S Clark, Adrienne L Edkins, Lawrence E Hightower

Cell Stress Chaperones· February 2024

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Stress biology: Complexity and multifariousness in health and disease.
Matthias P Mayer, Laura Blair, Gregory L Blatch, Thiago J Borges, Ahmed Chadli, Adrienne L Edkins

Cell Stress Chaperones· February 2024

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Mutations F352A and Y528A in human HSP90α reduce fibronectin association and fibrillogenesis in cell-derived matrices.
Abir Chakraborty, Ronald Tonui, Adrienne Lesley Edkins

Cell Stress Chaperones· November 2023

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Bimolecular Fluorescence Complementation Assay to Evaluate HSP90-Client Protein Interactions in Cells.
Abir Chakraborty, Gregory L Blatch, Adrienne L Edkins

Methods Mol Biol· August 2023

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Complementation Assays for Co-chaperone Function.
Adrienne L Edkins, Gregory L Blatch

Methods Mol Biol· August 2023

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Optimized Microscale Protein Aggregation Suppression Assay: A Method for Evaluating the Holdase Activity of Chaperones.
Ronald Tonui, Ruth O John, Adrienne L Edkins

Methods Mol Biol· August 2023

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Tackling Sleeping Sickness: Current and Promising Therapeutics and Treatment Strategies.
Miebaka Jamabo, Maduma Mahlalela, Adrienne L Edkins, Aileen Boshoff

Int J Mol Sci· August 2023

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Including African data in drug discovery and development.
Clinton G L Veale, Adrienne L Edkins, Susan Winks, Mathew Njoroge, Kelly Chibale

Nat Rev Drug Discov· July 2023

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Tenth International Symposium on the Hsp90 chaperone machine : Switzerland, October 19-23, 2022.
Adrienne L Edkins, Markus Zweckstetter, Ritwick Sawarkar

Cell Stress Chaperones· May 2023

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Biological and Medicinal Chemistry in Africa.
Clinton G L Veale, Temitope O Olomola, Prinessa Chellan, Adrienne L Edkins

Chembiochem· April 2023

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Comparative Analyses of Fucoidans from South African Brown Seaweeds That Inhibit Adhesion, Migration, and Long-Term Survival of Colorectal Cancer Cells.
Blessing Mabate, Chantal Désirée Daub, Brett Ivan Pletschke, Adrienne Lesley Edkins

Mar Drugs· March 2023

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Second Virtual International Symposium on Cellular and Organismal Stress Responses, September 8-9, 2022.
Patricija van Oosten-Hawle, Sarah J Backe, Anat Ben-Zvi, Dimitra Bourboulia, Mara Brancaccio, Adrienne Edkins

Cell Stress Chaperones· January 2023

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Hsp70/Hsp90 Organising Protein (Hop): Coordinating Much More than Chaperones.
Kelly Schwarz, Swati Baindur-Hudson, Gregory Lloyd Blatch, Adrienne Lesley Edkins

Subcell Biochem· December 2022

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CHIP: A Co-chaperone for Degradation by the Proteasome and Lysosome.
Abantika Chakraborty, Adrienne L Edkins

Subcell Biochem· December 2022

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