Publications by authors named "Mathew Njoroge"

Claim this Profile
O
Optimization of 2,8-Diaryl-1,5-naphthyridines as Phosphatidylinositol 4-Kinase Inhibitors with Improved ADME Profiles and In Vivo Efficacy.
Godwin A Dziwornu, Donald Seanego, Stephen Fienberg, Venkata S Sypu, Nicolaas Salomane, Mathew Njoroge

J Med Chem· October 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Artificial intelligence coupled to pharmacometrics modelling to tailor malaria and tuberculosis treatment in Africa.
Gemma Turon, Mwila Mulubwa, Anna Montaner, Mathew Njoroge, Kelly Chibale

Nat Commun· October 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel Inhibitors of Phosphatidylinositol 4-kinase IIIβ with Low Propensity for Resistance: Life Cycle Stage Activity and Efficacy in a Humanized Mouse Malaria Infection Model.
Godwin A Dziwornu, Mmakwena M Mmonwa, Dina Coertzen, Liezl Krugmann, Nicolaas Salomane, Mathew Njoroge

J Med Chem· August 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria.
John G Woodland, Dina Coertzen, Kathryn J Wicht, Virginia Franco Hidalgo, Charisse Flerida A Pasaje, Mathew Njoroge

Angew Chem Int Ed Engl· July 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Cell-Based Progression of Spiroindoline Phenotypic Hits Leads to the Identification of Compounds with Diverging Parasitological Profiles against the Human Malaria Parasite .
Jean Dam, Grant A Boyle, André Horatscheck, John G Woodland, Claire Le Manach, Mathew Njoroge

J Med Chem· May 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
CYP1A2 contributes to the metabolism of mefloquine: Exploration using in vitro metabolism and physiologically-based pharmacokinetic modelling.
Cleavon K Cloete, Preshendren Govender, Nicholas Njuguna, Neil J Parrott, Kenichi Umehara, Mathew Njoroge

Drug Metab Dispos· April 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis and SAR Studies of Acyl-Thiourea Platinum(II) Complexes Yield Analogs with Dual-Stage Antiplasmodium Activity.
Fatima-Zahra Ishmail, Dina Coertzen, Sizwe Tshabalala, Meta Leshabane, Shante da Rocha, Mathew Njoroge

ACS Med Chem Lett· March 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Benzimidazole analogues active against adult Schistosoma mansoni: SAR analyses, In vivo efficacy in mice, and preliminary mechanistic studies as potential inhibitors of hemozoin formation.
Godwin A Dziwornu, Henrietta Dede Attram, Cécile Haeberli, Keabetswe Masike, Mathew Njoroge

Eur J Med Chem· February 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Eliminating malaria transmission requires targeting immature and mature gametocytes through lipoidal uptake of antimalarials.
Mariska Naude, Ashleigh van Heerden, Janette Reader, Mariëtte van der Watt, Jandeli Niemand, Mathew Njoroge

Nat Commun· November 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Dose-fractionation studies of a phosphatidylinositol 4-kinase inhibitor in a humanized mouse model of malaria.
Liezl Gibhard, Mathew Njoroge, Mwila Mulubwa, Nina Lawrence, Dennis Smith

Antimicrob Agents Chemother· October 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The Tuberculosis Drug Candidate SQ109 and Its Analogs Have Multistage Activity against .
Savannah J Watson, Mariëtte E van der Watt, Anjo Theron, Janette Reader, Sizwe Tshabalala, Mathew Njoroge

ACS Infect Dis· September 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
2
2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Phosphatidylinositol-4-kinase and Hemozoin Formation with Efficacy.
Godwin Akpeko Dziwornu, Donald Seanego, Stephen Fienberg, Monica Clements, Jasmin Ferreira, Mathew Njoroge

J Med Chem· July 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
AI can help to tailor drugs for Africa - but Africans should lead the way.
Gemma Turon, Mathew Njoroge, Mwila Mulubwa, Miquel Duran-Frigola, Kelly Chibale

Nature· April 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
hERG, Life Cycle, and Cross Resistance Profiling of New Azabenzimidazole Analogues of Astemizole.
Dickson Mambwe, Dina Coertzen, Meta Leshabane, Mwila Mulubwa, Mathew Njoroge

ACS Med Chem Lett· April 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Including African data in drug discovery and development.
Clinton G L Veale, Adrienne L Edkins, Susan Winks, Mathew Njoroge, Kelly Chibale

Nat Rev Drug Discov· July 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Antimalarial Imidazopyridines Incorporating an Intramolecular Hydrogen Bonding Motif: Medicinal Chemistry and Mechanistic Studies.
Henrietta D Attram, Constance M Korkor, Dale Taylor, Mathew Njoroge, Kelly Chibale

ACS Infect Dis· April 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and Efficacy in a Mouse Malaria Infection Model.
Dickson Mambwe, Constance M Korkor, Amanda Mabhula, Zama Ngqumba, Cleavon Cloete, Mathew Njoroge

J Med Chem· December 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Total Synthesis of the Antimycobacterial Natural Product Chlorflavonin and Analogs via a Late-Stage Ruthenium(II)-Catalyzed -C(sp)-H-Hydroxylation.
Alexander Berger, Talea Knak, Anna-Lene Kiffe-Delf, Korana Mudrovcic, Vinayak Singh, Mathew Njoroge

Pharmaceuticals (Basel)· August 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones.
Gregory S Basarab, Sandeep Ghorpade, Liezl Gibhard, Rudolf Mueller, Mathew Njoroge

Antimicrob Agents Chemother· April 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
1
1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in .
Lutete Peguy Khonde, Rudolf Müller, Grant A Boyle, Virsinha Reddy, Aloysius T Nchinda, Mathew Njoroge

J Med Chem· September 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure-Activity Relationship Studies Reveal New Astemizole Analogues Active against In Vitro.
Dickson Mambwe, Malkeet Kumar, Richard Ferger, Dale Taylor, Mathew Njoroge

ACS Med Chem Lett· August 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Benzoheterocyclic Oxime Carbamates Active against : Synthesis, Structure-Activity Relationship, Metabolism, and Biology Triaging.
Renier van der Westhuyzen, Amanda Mabhula, Paul M Njaria, Rudolf Müller, Denis Ngumbu Muhunga, Mathew Njoroge

J Med Chem· July 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure-Activity Relationship and Oral Efficacy Studies.
Godwin Akpeko Dziwornu, Dina Coertzen, Meta Leshabane, Constance M Korkor, Cleavon K Cloete, Mathew Njoroge

J Med Chem· April 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Correction to "Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and Efficacy in the NSG Mouse Model".
André Horatscheck, Ana Andrijevic, Aloysius T Nchinda, Claire Le Manach, Tanya Paquet, Mathew Njoroge

J Med Chem· February 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite and Optimization Efforts.
Claire Le Manach, Jean Dam, John G Woodland, Gurminder Kaur, Lutete P Khonde, Mathew Njoroge

J Med Chem· February 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis