Publications by authors named "Ae N Pae"

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Discovery of Novel β-Arrestin Biased Sphingosine-1-Phosphate-1 Receptor Agonists for the Treatment of Multiple Sclerosis.
Chang Yong Lee, Lizaveta Gotina, Jushin Kim, Jaehwan Kim, Jee Yun Ahn, Ae Nim Pae

J Med Chem· September 2025

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Structural Basis for D3/D4-Selective Antagonism of Piperazinylalkyl Pyrazole/Isoxazole Analogs.
Kwang-Eun Choi, Seong Hun Jang, Woo-Kyu Park, Kyoung Tai No, Hun Yeong Koh, Ae Nim Pae

Molecules· September 2025

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Hemoglobin as a pseudoperoxidase and drug target for oxidative stress-related diseases.
Woojin Won, Elijah Hwejin Lee, Lizaveta Gotina, Heejung Chun, Jae-Hun Lee, Ae Nim Pae

Signal Transduct Target Ther· August 2025

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Mice deficient in TWIK-1 are more susceptible to kainic acid-induced seizures.
Ajung Kim, Yeonju Bae, Changdev G Gadhe, Hyun-Gug Jung, Esther Yang, Ae Nim Pae

iScience· January 2025

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Neuroprotective Effects of Ethanol Extract (EEPG) Against Glutamate Induced Neurotoxicity in HT22 Cells.
Qui Ngoc Sang Nguyen, Ki-Yeon Yoo, Thi Thu Trang Pham, Baskar Selvaraj, Huong Thuy Vu, Ae Nim Pae

Int J Mol Sci· November 2024

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Highly potent and selective PPARδ agonist reverses memory deficits in mouse models of Alzheimer's disease.
Hyeon Jeong Kim, Haelee Kim, Jaeyoung Song, Jun Young Hong, Elijah Hwejin Lee, Ae Nim Pae

Theranostics· October 2024

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Structural determinants for activation of the Tau kinase CDK5 by the serotonin receptor 5-HT7R.
Jana Ackmann, Alina Brüge, Lizaveta Gotina, Sungsu Lim, Kathrin Jahreis, Ae Nim Pae

Cell Commun Signal· April 2024

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NeuM: A Neuron-Selective Probe Incorporates into Live Neuronal Membranes via Enhanced Clathrin-Mediated Endocytosis in Primary Neurons.
Yoonsik Sung, Lizaveta Gotina, Kyu Hyeon Kim, Jung Yeol Lee, Seulgi Shin, Ae Nim Pae

Angew Chem Int Ed Engl· January 2024

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Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants.
Elliot H Lee, Jung-Eun Park, Lizaveta Gotina, Young-Eun Han, Ambily Nath Indu Viswanath, Ae Nim Pae

Biomed Pharmacother· September 2023

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Exploration of Tetrahydroisoquinoline- and Benzo[]azepine-Based Sphingosine 1-Phosphate Receptor 1 Agonists for the Treatment of Multiple Sclerosis.
Eunji Cha, Jushin Kim, Lizaveta Gotina, Jaehwan Kim, Hyeon Jeong Kim, Ae Nim Pae

J Med Chem· August 2023

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Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in Tau-BiFC mice.
Sungsu Lim, Seulgi Shin, Yoonsik Sung, Ha Eun Lee, Kyu Hyeon Kim, Ae Nim Pae

Exp Mol Med· March 2023

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Neuroprotective Effects of Ethanol Extract of (EEPF) against Glutamate-Mediated Neuronal Toxicity in HT22 Cells.
Baskar Selvaraj, Tam Thi Le, Dae Won Kim, Bo Hyun Jung, Ki-Yeon Yoo, Ae Nim Pae

Int J Mol Sci· February 2023

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Glutamate Permeability of Chicken Best1.
Jung Moo Lee, Changdev Gorakshnath Gadhe, Hyunji Kang, Ae Nim Pae, C Justin Lee

Exp Neurobiol· October 2022

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Identification of novel discoidin domain receptor 1 (DDR1) inhibitors using E-pharmacophore modeling, structure-based virtual screening, molecular dynamics simulation and MM-GBSA approaches.
Hossam Nada, Kyeong Lee, Lizaveta Gotina, Ae Nim Pae, Ahmed Elkamhawy

Comput Biol Med· March 2022

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The translocator protein ligands as mitochondrial functional modulators for the potential anti-Alzheimer agents.
TaeHun Kim, Mohammad N Morshed, Ashwini M Londhe, Ji W Lim, Ha E Lee, Ae N Pae

J Enzyme Inhib Med Chem· December 2021

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Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington's disease mouse model.
Yu Jin Hwang, Seung Jae Hyeon, Younghee Kim, Sungsu Lim, Min Young Lee, Ae Nim Pae

J Enzyme Inhib Med Chem· December 2021

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Highly Potent, Selective, and Competitive Indole-Based MAO-B Inhibitors Protect PC12 Cells against 6-Hydroxydopamine- and Rotenone-Induced Oxidative Stress.
Mohamed H Elsherbeny, Jushin Kim, Noha A Gouda, Lizaveta Gotina, Jungsook Cho, Ae Nim Pae

Antioxidants (Basel)· October 2021

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Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion.
Tai Young Kim, Sangeun Jeon, Youngho Jang, Lizaveta Gotina, Joungha Won, Ae Nim Pae

Exp Mol Med· May 2021

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Pharmacophore-Based Virtual Screening of Novel Competitive Inhibitors of the Neurodegenerative Disease Target Kynurenine-3-Monooxygenase.
Lizaveta Gotina, Seon Hee Seo, Chae Won Kim, Sang Min Lim, Ae Nim Pae

Molecules· May 2021

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Discovery of -(1-(3-fluorobenzoyl)-1-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B.
Ahmed Elkamhawy, Sora Paik, Hyeon Jeong Kim, Jong-Hyun Park, Ashwini M Londhe, Ae Nim Pae

J Enzyme Inhib Med Chem· December 2020

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Molecular Characterization of Hepatitis C Virus for Developed Antiviral Agents Resistance Mutations and New Insights into in-silico Prediction Studies.
Mohamed M Adel El-Sokkary, Lizaveta Gotina, Mohammad M Al-Sanea, Ae Nim Pae, Rehab Mohammed Elbargisy

Infect Drug Resist· November 2020

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PyrPeg, a Blood-Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates.
Ji-Woo Choi, Yeon Ha Ju, Yunsook Choi, Seung Jae Hyeon, Changdev G Gadhe, Ae Nim Pae

ACS Chem Neurosci· June 2020

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Nrf2 activator via interference of Nrf2-Keap1 interaction has antioxidant and anti-inflammatory properties in Parkinson's disease animal model.
Siwon Kim, Ambily Nath Indu Viswanath, Jong-Hyun Park, Ha Eun Lee, A Yeong Park, Ae Nim Pae

Neuropharmacology· May 2020

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Visualization of soluble tau oligomers in TauP301L-BiFC transgenic mice demonstrates the progression of tauopathy.
Seulgi Shin, Dohee Kim, Ji Yeon Song, Hyeanjeong Jeong, Seung Jae Hyeon, Ae Nim Pae

Prog Neurobiol· April 2020

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CRISPR-mediated gene correction links the ATP7A M1311V mutations with amyotrophic lateral sclerosis pathogenesis in one individual.
Yeomin Yun, Sung-Ah Hong, Ka-Kyung Kim, Daye Baek, Dongsu Lee, Ae Nim Pae

Commun Biol· January 2020

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