Publications by authors named "Afreen Haider"

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Loss of Mfn1 but not Mfn2 enhances adipogenesis.
Jake P Mann, Luis Carlos Tábara, Satish Patel, Pushpa Pushpa, Anna Alvarez-Guaita, Afreen Haider

PLoS One· December 2024

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Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 Inhibitors.
Simon C C Lucas, J Henry Blackwell, Ulf Börjesson, David Hargreaves, Alexander G Milbradt, Afreen Haider

J Med Chem· September 2024

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Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS with Demonstrable CNS Penetration.
Jason G Kettle, Sharan K Bagal, Derek Barratt, Michael S Bodnarchuk, Scott Boyd, Afreen Haider

J Med Chem· July 2023

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A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion.
Jake P Mann, Xiaowen Duan, Satish Patel, Luis Carlos Tábara, Fabio Scurria, Afreen Haider

Elife· February 2023

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Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice.
Satish Patel, Afreen Haider, Anna Alvarez-Guaita, Guillaume Bidault, Julia Sarah El-Sayed Moustafa

Mol Metab· November 2022

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Accelerating the Validation of Endogenous On-Target Engagement and In Cellulo Kinetic Assessment for Covalent Inhibitors of KRAS in Early Drug Discovery.
Vasudev Kantae, Radoslaw Polanski, Hilary J Lewis, Afreen Haider, Derek Barratt

ACS Chem Biol· August 2022

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Correction: Conserved amphipathic helices mediate lipid droplet targeting of perilipins 1-3.
Emily R Rowe, Michael L Mimmack, Antonio D Barbosa, Afreen Haider, Iona Isaac

J Biol Chem· January 2022

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Lipodistrophy: a paradigm for understanding the consequences of "overloading" adipose tissue.
Koini Lim, Afreen Haider, Claire Adams, Alison Sleigh, David B Savage

Physiol Rev· July 2021

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Phenotypic characterization of Adig null mice suggests roles for adipogenin in the regulation of fat mass accrual and leptin secretion.
Anna Alvarez-Guaita, Satish Patel, Koini Lim, Afreen Haider, Liang Dong

Cell Rep· March 2021

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Characterization of mitochondrion-targeted GTPases in Plasmodium falciparum.
Kirti Gupta, Ankit Gupta, Afreen Haider, Saman Habib

Parasitology· October 2018

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PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress.
Afreen Haider, Yu-Chen Wei, Koini Lim, Antonio D Barbosa, Che-Hsiung Liu

Dev Cell· May 2018

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Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1-3.
Emily R Rowe, Michael L Mimmack, Antonio D Barbosa, Afreen Haider, Iona Isaac

J Biol Chem· March 2016

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Targeting and function of proteins mediating translation initiation in organelles of Plasmodium falciparum.
Afreen Haider, Stacey M Allen, Katherine E Jackson, Stuart A Ralph, Saman Habib

Mol Microbiol· May 2015

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Reduced ribosomes of the apicoplast and mitochondrion of Plasmodium spp. and predicted interactions with antibiotics.
Ankit Gupta, Priyanka Shah, Afreen Haider, Kirti Gupta, Mohammad Imran Siddiqi

Open Biol· May 2014

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