Publications by authors named "Afshan McCarthy"

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CRISPR/Cas9-mediated generation of GATA3 knockout in Bovine Fibroblast and MDBK cell lines to assess sgRNAs targeting efficiency.
Qurat Ul Ain, Afshan McCarthy, Asif Nadeem, Maryam Javed, Kathy Niakan

Funct Integr Genomics· December 2025

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Live imaging of late-stage preimplantation human embryos reveals de novo mitotic errors.
Ahmed Abdelbaki, Afshan McCarthy, Anita Karsa, Leila Muresan, Kay Elder

Nat Biotechnol· October 2025

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Heart of the matter: Neutrophils, cancer, and cardiovascular disease.
Saira Ambreen, Afshan McCarthy, Andrés Hidalgo, Jose M Adrover

J Exp Med· September 2025

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Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst.
Claire S Simon, Afshan McCarthy, Laura Woods, Desislava Staneva, Martin Proks

Nat Commun· July 2025

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Initiation and maintenance of the pluripotent epiblast in pre-implantation human development is independent of NODAL signaling.
A Sophie Brumm, Afshan McCarthy, Claudia Gerri, Todd Fallesen, Laura Woods

Dev Cell· January 2025

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mTOR activity paces human blastocyst stage developmental progression.
Dhanur P Iyer, Heidar Heidari Khoei, Vera A van der Weijden, Harunobu Kagawa, Saurabh J Pradhan, Afshan McCarthy

Cell· November 2024

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Transcription factor-based transdifferentiation of human embryonic to trophoblast stem cells.
Paula A Balestrini, Ahmed Abdelbaki, Afshan McCarthy, Liani Devito, Claire E Senner

Development· September 2024

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MICA: a multi-omics method to predict gene regulatory networks in early human embryos.
Gregorio Alanis-Lobato, Thomas E Bartlett, Qiulin Huang, Claire S Simon, Afshan McCarthy

Life Sci Alliance· January 2024

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A conserved role of the Hippo signalling pathway in initiation of the first lineage specification event across mammals.
Claudia Gerri, Afshan McCarthy, Gwen Mei Scott, Marius Regin, Panagiotis Stamatiadis

Development· April 2023

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KLF17 promotes human naïve pluripotency but is not required for its establishment.
Rebecca A Lea, Afshan McCarthy, Stefan Boeing, Todd Fallesen, Kay Elder

Development· November 2021

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Generating CRISPR-Cas9-Mediated Null Mutations and Screening Targeting Efficiency in Human Pluripotent Stem Cells.
Oliver J Bower, Afshan McCarthy, Rebecca A Lea, Gregorio Alanis-Lobato, Jasmin Zohren

Curr Protoc· August 2021

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Frequent loss of heterozygosity in CRISPR-Cas9-edited early human embryos.
Gregorio Alanis-Lobato, Jasmin Zohren, Afshan McCarthy, Norah M E Fogarty, Nada Kubikova

Proc Natl Acad Sci U S A· June 2021

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TRF2-independent chromosome end protection during pluripotency.
Phil Ruis, David Van Ly, Valerie Borel, Georgia R Kafer, Afshan McCarthy

Nature· January 2021

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Initiation of a conserved trophectoderm program in human, cow and mouse embryos.
Claudia Gerri, Afshan McCarthy, Gregorio Alanis-Lobato, Andrej Demtschenko, Alexandre Bruneau

Nature· November 2020

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The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes.
Elias ElInati, Agata P Zielinska, Afshan McCarthy, Nada Kubikova, Valdone Maciulyte

Nat Commun· May 2020

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IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche.
Sissy E Wamaitha, Katarzyna J Grybel, Gregorio Alanis-Lobato, Claudia Gerri, Sugako Ogushi, Afshan McCarthy

Nat Commun· February 2020

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Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine.
Boris Y Shorning, Joanna Zabkiewicz, Afshan McCarthy, Helen B Pearson, Douglas J Winton

PLoS One· September 2019

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Erratum: Genome editing reveals a role for OCT4 in human embryogenesis.
Norah M E Fogarty, Afshan McCarthy, Kirsten E Snijders, Benjamin E Powell, Nada Kubikova

Nature· November 2017

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Genome editing reveals a role for OCT4 in human embryogenesis.
Norah M E Fogarty, Afshan McCarthy, Kirsten E Snijders, Benjamin E Powell, Nada Kubikova

Nature· October 2017

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Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.
Sandra Kümper, Faraz K Mardakheh, Afshan McCarthy, Maggie Yeo, Gordon W Stamp

Elife· January 2016

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Global Analysis of mRNA, Translation, and Protein Localization: Local Translation Is a Key Regulator of Cell Protrusions.
Faraz K Mardakheh, Angela Paul, Sandra Kümper, Amine Sadok, Hugh Paterson, Afshan Mccarthy

Dev Cell· November 2015

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Rho kinase inhibitors block melanoma cell migration and inhibit metastasis.
Amine Sadok, Afshan McCarthy, John Caldwell, Ian Collins, Michelle D Garrett

Cancer Res· June 2015

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AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival.
Mercedes Rodriguez-Teja, Julian H Gronau, Claudia Breit, Yu Zhi Zhang, Ai Minamidate, Afshan McCarthy

J Pathol· March 2015

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Tumor suppressor role of phospholipase C epsilon in Ras-triggered cancers.
Marta Martins, Afshan McCarthy, Rhona Baxendale, Sabrina Guichard, Lorenza Magno

Proc Natl Acad Sci U S A· March 2014

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Aurora A kinase regulates mammary epithelial cell fate by determining mitotic spindle orientation in a Notch-dependent manner.
Joseph L Regan, Tony Sourisseau, Kelly Soady, Howard Kendrick, Afshan McCarthy

Cell Rep· July 2013

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