Publications by authors named "Michelle D Garrett"

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Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor-adapted non-small cell lung cancer cell lines.
Tharsagini V Nanthaprakash, Campbell W Gourlay, Ina Oehme, Michelle D Garrett, Jindrich Cinatl

FEBS Open Bio· November 2025

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Using a novel panel of drug-resistant triple-negative breast cancer cell lines to identify candidate therapeutic targets and biomarkers.
Helen E Grimsley, Magdalena Antczak, Ian G Reddin, Nicole Weiler, Katie-May McLaughlin, Michelle D Garrett

Cancer Lett· August 2025

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Towards the development of supramolecular self-associating amphiphiles as antibiofilm agents against and biofilms.
Kira L F Hilton, Hendrik J F Steyn, Kusasalethu S Luthuli, Matthew Rice, Bree R Streather, Michelle D Garrett

J Mater Chem B· July 2025

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Correction: AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity.
Timothy A Yap, Mike I Walton, Kyla M Grimshaw, Robert H Te Poele, Paul D Eve, Michelle D Garrett

Clin Cancer Res· July 2025

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Sequence-defined phosphoestamers for selective inhibition of the KRAS/RAF1 interaction.
Bini Claringbold, Steven Vance, Alexandra R Paul, James Williamson, Michelle D Garrett

Chem Sci· December 2024

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Synthesis and cytotoxic activity of madecassic acid-silybin conjugate compounds in liver cancer cells.
Chien Van Tran, Thao Thi Phuong Tran, Anh The Nguyen, Loc Van Tran, Ninh Thi Pham, Michelle D Garrett

RSC Med Chem· August 2024

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Selection of optimised ligands by fluorescence-activated bead sorting.
Alexandra R Paul, Mario Falsaperna, Helen Lavender, Michelle D Garrett, Christopher J Serpell

Chem Sci· September 2023

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Hydroxylated polymethoxyflavones reduce the activity of pancreatic lipase, inhibit adipogenesis and enhance lipolysis in 3T3-L1 mouse embryonic fibroblast cells.
Bilal Ahmad, Emily P Friar, Muhammad Sufyan Vohra, Nasar Khan, Christopher J Serpell, Michelle D Garrett

Chem Biol Interact· July 2023

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Anti-pancreatic lipase and anti-adipogenic effects of 5, 7, 3',4',5' -pentamethoxy and 6, 2',4'-trimethoxy flavone - An In vitro study.
Bilal Ahmad, Emily P Friar, Emerald Taylor, Muhammad Sufyan Vohra, Christopher J Serpell, Michelle D Garrett

Eur J Pharmacol· January 2023

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Sequence-complementarity dependent co-assembly of phosphodiester-linked aromatic donor-acceptor trimers.
Nadeema Appukutti, Alex H de Vries, Prashant G Gudeangadi, Bini R Claringbold, Michelle D Garrett

Chem Commun (Camb)· November 2022

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Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance.
Jill E Hunter, Amy E Campbell, Jacqueline A Butterworth, Helene Sellier, Nicola L Hannaway, Michelle D Garrett

Biochem J· October 2022

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Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway.
Jill E Hunter, Amy E Campbell, Nicola L Hannaway, Scott Kerridge, Saimir Luli, Michelle D Garrett

Biochem J· October 2022

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Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of 'druggable' supramolecular self-associating antimicrobial amphiphiles.
Jessica E Boles, Charlotte Bennett, Jennifer Baker, Kira L F Hilton, Hiral A Kotak, Michelle D Garrett

Chem Sci· August 2022

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The phospholipid membrane compositions of bacterial cells, cancer cell lines and biological samples from cancer patients.
Kira L F Hilton, Chandni Manwani, Jessica E Boles, Lisa J White, Sena Ozturk, Michelle D Garrett

Chem Sci· October 2021

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Supramolecular self-associating amphiphiles (SSAs) as nanoscale enhancers of cisplatin anticancer activity.
Nova O Dora, Edith Blackburn, Jessica E Boles, George T Williams, Lisa J White, Michelle D Garrett

RSC Adv· April 2021

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Mechanisms of action for the anti-obesogenic activities of phytochemicals.
Bilal Ahmad, Emily P Friar, Muhammad Sufyan Vohra, Michelle D Garrett, Christopher J Serpell

Phytochemistry· December 2020

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First-in-Human Study of AT13148, a Dual ROCK-AKT Inhibitor in Patients with Solid Tumors.
Robert McLeod, Rajiv Kumar, Dionysis Papadatos-Pastos, Joaquin Mateo, Jessica S Brown, Michelle D Garrett

Clin Cancer Res· September 2020

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CHK1 Inhibition Is Synthetically Lethal with Loss of B-Family DNA Polymerase Function in Human Lung and Colorectal Cancer Cells.
Rebecca F Rogers, Michael I Walton, Daniel L Cherry, Ian Collins, Paul A Clarke, Michelle D Garrett

Cancer Res· April 2020

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Metabolomic changes of the multi (-AGC-) kinase inhibitor AT13148 in cells, mice and patients are associated with NOS regulation.
Akos Pal, Yasmin Asad, Ruth Ruddle, Alan T Henley, Karen Swales, Michelle D Garrett

Metabolomics· April 2020

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A Phase I Open-Label Study to Identify a Dosing Regimen of the Pan-AKT Inhibitor AZD5363 for Evaluation in Solid Tumors and in -Mutated Breast and Gynecologic Cancers.
Udai Banerji, Emma J Dean, J Alejandro Pérez-Fidalgo, Gerald Batist, Philippe L Bedard, Michelle D Garrett

Clin Cancer Res· May 2018

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Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.
Steven R Whittaker, Clare Barlow, Mathew P Martin, Caterina Mancusi, Steve Wagner, Michelle D Garrett

Mol Oncol· March 2018

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Acquired resistance to oxaliplatin is not directly associated with increased resistance to DNA damage in SK-N-ASrOXALI4000, a newly established oxaliplatin-resistant sub-line of the neuroblastoma cell line SK-N-AS.
Emily Saintas, Liam Abrahams, Gulshan T Ahmad, Anu-Oluwa M Ajakaiye, Abdulaziz S H A M AlHumaidi, Michelle D Garrett

PLoS One· August 2017

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Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells.
Vadim V Sumbayev, Isabel Gonçalves Silva, Jennifer Blackburn, Bernhard F Gibbs, Inna M Yasinska, Michelle D Garrett

Oncotarget· July 2016

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Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737).
James D Osborne, Thomas P Matthews, Tatiana McHardy, Nicolas Proisy, Kwai-Ming J Cheung, Michelle D Garrett

J Med Chem· June 2016

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Novel pharmacodynamic biomarkers for MYCN protein and PI3K/AKT/mTOR pathway signaling in children with neuroblastoma.
Jennifer R Smith, Lucas Moreno, Simon P Heaton, Louis Chesler, Andrew D J Pearson, Michelle D Garrett

Mol Oncol· April 2016

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