Publications by authors named "Mathew P Martin"

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Covalent Alkynylpyridopyrimidinones Targeting Cysteine 775 of the Epidermal Growth Factor Receptor Overcome Resistance to Current Therapies.
Hannah L Stewart, Cinzia Bordoni, Claire E Jennings, Islam Al-Khawaldeh, Mathew P Martin, Martin E M Noble

J Med Chem· December 2025

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Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction.
Ian Hope, Mathew P Martin, Ziwei Jiang, Michael J Waring, Martin E M Noble

Structure· November 2025

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Author Correction: Factors affecting irreversible inhibition of EGFR and influence of chirality on covalent binding.
Pasquale A Morese, Ayaz Ahmad, Mathew P Martin, Richard A Noble, Sara Pintar, Martin E M Noble

Commun Chem· May 2025

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Factors affecting irreversible inhibition of EGFR and influence of chirality on covalent binding.
Pasquale A Morese, Ayaz Ahmad, Mathew P Martin, Richard A Noble, Sara Pintar, Martin E M Noble

Commun Chem· April 2025

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Different applications and differentiated libraries for crystallographic fragment screening.
Jessica Watt, Mathew P Martin, Jane A Endicott, Martin E M Noble

Curr Opin Struct Biol· February 2025

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Crystallographic fragment screening in academic cancer drug discovery.
Mathew P Martin, Jane A Endicott, Martin E M Noble, Natalie J Tatum

Methods Enzymol· October 2023

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Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release.
Pasquale A Morese, Nahoum Anthony, Michael Bodnarchuk, Claire Jennings, Mathew P Martin, Martin E M Noble

J Med Chem· September 2023

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Conformational study into N-alkyl-N'-aryl ureas to inform drug discovery.
Hannah L Stewart, Marta Bon, Corinne Wills, Mathew P Martin, Lan Z Wang

Bioorg Med Chem· August 2023

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Comparison of Quantitative Mass Spectrometric Methods for Drug Target Identification by Thermal Proteome Profiling.
Amy L George, Frances R Sidgwick, Jessica E Watt, Mathew P Martin, Matthias Trost

J Proteome Res· August 2023

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Fragment expansion with NUDELs - poised DNA-encoded libraries.
Catherine L A Salvini, Benoit Darlot, Jack Davison, Mathew P Martin, Susan J Tudhope, Martin E M Noble

Chem Sci· August 2023

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Modulation of ERK5 Activity as a Therapeutic Anti-Cancer Strategy.
Duncan C Miller, Suzannah J Harnor, Mathew P Martin, Richard A Noble, Stephen R Wedge

J Med Chem· April 2023

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Exiting the tunnel of uncertainty: crystal soak to validated hit.
Mathew P Martin, Martin E M Noble

Acta Crystallogr D Struct Biol· November 2022

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Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions.
Gemma Davison, Mathew P Martin, Shannon Turberville, Selma Dormen, Richard Heath, Martin E M Noble

J Med Chem· November 2022

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A Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Assay Identifies Nilotinib as an Inhibitor of Inflammation in Acute Myeloid Leukemia.
José Luis Marín-Rubio, Rachel E Peltier-Heap, Maria Emilia Dueñas, Tiaan Heunis, Abeer Dannoura, Mathew P Martin

J Med Chem· September 2022

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Build-Couple-Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity.
Mélanie Uguen, Gemma Davison, Lukas J Sprenger, James H Hunter, Mathew P Martin, Martin E M Noble

J Med Chem· August 2022

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Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor.
Duncan C Miller, Tristan Reuillon, Lauren Molyneux, Timothy Blackburn, Simon J Cook, Mathew P Martin, Nick C Martin, Martin E M Noble

J Med Chem· May 2022

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An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase.
Islam Al-Khawaldeh, Mohammed J Al Yasiri, Gregory G Aldred, Christine Basmadjian, Cinzia Bordoni, Mathew P Martin, Martin E M Noble

J Med Chem· July 2021

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Recent Advances in Kinase Drug Discovery Part I: The Editors' Take.
Julie A Tucker, Mathew P Martin

Int J Mol Sci· July 2021

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Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease.
Alice Douangamath, Daren Fearon, Paul Gehrtz, Tobias Krojer, Petra Lukacik, Mathew P Martin, Martin E M Noble, Martin A Walsh

Nat Commun· October 2020

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Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4.
Stephanie M Myers, Duncan C Miller, Lauren Molyneux, Mercedes Arasta, Ruth H Bawn, Mathew P Martin, Nick C Martin, Martin E M Noble

Eur J Med Chem· September 2019

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FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
Daniel J Wood, J Daniel Lopez-Fernandez, Leanne E Knight, Islam Al-Khawaldeh, Conghao Gai, Mathew P Martin, Martin E M Noble

J Med Chem· April 2019

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Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Daniel J Wood, Svitlana Korolchuk, Natalie J Tatum, Lan-Zhen Wang, Jane A Endicott, Martin E M Noble, Mathew P Martin

Cell Chem Biol· January 2019

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Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.
Steven R Whittaker, Clare Barlow, Mathew P Martin, Caterina Mancusi, Steve Wagner, Martin Noble

Mol Oncol· March 2018

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Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach.
Duncan C Miller, Mathew P Martin, Santosh Adhikari, Alfie Brennan, Jane A Endicott, Martin E M Noble

Org Biomol Chem· March 2018

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Structure-based discovery of cyclin-dependent protein kinase inhibitors.
Mathew P Martin, Jane A Endicott, Martin E M Noble

Essays Biochem· November 2017

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