Publications by authors named "Timothy A Yap"

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The Promise of Poly(ADP-Ribose) Polymerase (PARP) Inhibitors in Gliomas.
Nazanin Majd, Timothy A Yap, W K Alfred Yung, John de Groot

November 2020

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FDA-AACR Strategies for Optimizing Dosages for Oncology Drug Products: Early-Phase Trials Using Innovative Trial Designs and Biomarkers.
Olanrewaju O Okusanya, Gabriela I Patilea-Vrana, Anthony Sireci, Alexia Iasonos, Brad A Davidson, Timothy A Yap

Clin Cancer Res· December 2025

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YAP/TEAD inhibitor VT3989 in solid tumors: a phase 1/2 trial.
Timothy A Yap, David J Kwiatkowski, Ibiayi Dagogo-Jack, Michael Offin, Marjorie G Zauderer

Nat Med· December 2025

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CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen.
Nealia C House, Maxine M Chen, Sima Khazaei, Victoria Brown, Philip Ramsden, Timothy A Yap

NPJ Breast Cancer· December 2025

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Circulating tumor DNA as a biomarker in early phase clinical trials.
Harold N Tan, Mitchell J Elliott, Ian M Silverman, Lillian L Siu, Timothy A Yap

Cancer Cell· December 2025

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A First-in-Human Study of ATM Inhibitor Lartesertib as Monotherapy in Patients with Advanced Solid Tumors.
Lillian L Siu, Timothy A Yap, Sofia Genta, Gregory Pennock, Christine Hicking

Clin Cancer Res· November 2025

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Germline Mutations as Cancer Drug Targets.
Tin-Yun Tang, Karen Colbert Maresso, Joanne Ngeow, Eduardo Vilar, Timothy A Yap

Cancer Discov· November 2025

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Baseline PARP-1 PET imaging in patients with advanced solid tumors with DNA damage response mutations.
Tarek Daoud, Jiansong Chen, Peng Wei, Franklin Wong, Timothy A Yap

Eur J Nucl Med Mol Imaging· November 2025

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Prognosis and treatment response stratification according to loss of proofreading (LOP) variants.
Giulia Maddalena, Fadl A Zeineddine, Saikat Chowdhury, Mohammad A Zeineddine, Abdelrahman M Yousef, Timothy A Yap

J Immunother Cancer· November 2025

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YAP1 Depletion Enhances TAZ and its Complexation with TEAD4 and AP-1 Heterodimer C-JUN/FOSB to Promote Gastric Cancer Progression and Metastases.
Jingjing Wu, Dipti Athavale, Curt Balch, Junsong Zhao, Gengyi Zou, Timothy Anthony Yap

bioRxiv· November 2025

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Phase Ib Basket Expansion Trial and Alternative-Schedule Dose-Escalation Study of ATR Inhibitor Elimusertib in Advanced Solid Tumors with DNA Damage Response Defects.
Timothy A Yap, David S P Tan, Anastasios Stathis, Geoffrey I Shapiro, Satoru Iwasa

Cancer Discov· October 2025

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Genomic and Epigenomic ctDNA Profiling in Liquid Biopsies from Heavily Pretreated Patients with DNA Damage Response-Deficient Tumors.
Ian M Silverman, Joseph D Schonhoft, Benjamin Herzberg, Arielle Yablonovitch, Errin Lagow, Timothy A Yap

Clin Cancer Res· October 2025

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Drugging the DNA damage response in the clinic: going beyond PARP.
Carlos Torrado, Alvaro Gonzalez-Ortiz, Camila B Xavier, Harold N Tan, Natalie Y L Ngoi, Timothy A Yap

Expert Rev Anticancer Ther· October 2025

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Efficacy of ATR Kinase Inhibitor Elimusertib Monotherapy or Combination in Tumors with DNA Damage Response Pathway and Other Genomic Alterations.
Kaushik Varadarajan, Christian X Cruz Pico, Kurt W Evans, Maria Gabriela Raso, Yasmeen Qamar Rizvi, Timothy A Yap

Mol Cancer Ther· September 2025

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Overcoming Resistance to CDK4/6 inhibitors in Hormone Receptor positive, HER2 negative breast cancer: Innovative Combinations and Emerging Strategies.
Federica Giugliano, Carmine De Angelis, Barbara Pistilli, Giulia Viale, Giampaolo Bianchini, Timothy A Yap

Cancer Treat Rev· September 2025

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Modulating Treatment Outcomes of Patients with Solid Tumors in Immunotherapy Trials: A Drug Interaction Analysis from a Phase I Unit.
Camila Braganca Xavier, Clark R Andersen, JoAnn Lim, Julian H Slade, Stacie A Bean, Timothy A Yap

Cancer Res Commun· September 2025

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The DNA-PK inhibitor AZD7648 alone or combined with pegylated liposomal doxorubicin in patients with advanced cancer: results of a first-in-human Phase I/IIa study.
Timothy A Yap, Patricia LoRusso, Rowan E Miller, Rebecca Kristeleit, Amanda G Paulovich

Br J Cancer· August 2025

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Integrated Population Pharmacokinetic, Pharmacodynamic, and Safety Analyses to Inform Dosage Selection in the Clinical Development of the ATR Inhibitor Tuvusertib.
Jatinder Kaur Mukker, Paul Matthias Diderichsen, Farina Hellmann, Timothy A Yap, Ruth Plummer, Jayaprakasam Bolleddula

Clin Pharmacol Ther· August 2025

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USP1 inhibition: A journey from target discovery to clinical translation.
Carlos Torrado, Nicholas W Ashton, Alan D D'Andrea, Timothy A Yap

Pharmacol Ther· July 2025

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First-in-human phase 1 study of KHK2455 monotherapy and in combination with mogamulizumab in patients with advanced solid tumors.
Timothy A Yap, Olivier Rixe, Capucine Baldini, Ursa Brown-Glaberman, Sergey Efuni

Cancer· July 2025

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Correction: AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity.
Timothy A Yap, Mike I Walton, Kyla M Grimshaw, Robert H Te Poele, Paul D Eve

Clin Cancer Res· July 2025

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Exceptional response to the ATR inhibitor, camonsertib, in a patient with ALT+ metastatic melanoma.
Natalie Y L Ngoi, Ian M Silverman, Adrienne Johnson, Chenfeng Meng, Joseph D Schonhoft, Timothy A Yap

NPJ Precis Oncol· July 2025

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Unlocking the therapeutic potential of ATR inhibitors: Advances, challenges, and opportunities in cancer therapy.
Tejaswini P Reddy, Timothy A Yap

Clin Transl Med· July 2025

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Phase 1 first-in-human dose-escalation study of IMSA101, a novel cyclic di-nucleotide STING agonist, for patients with advanced solid tumor malignancies.
Jay Jacoby, Deva Mahalingam, Angela Alistar, Edward Garmey, Syed Kazmi, Timothy A Yap

J Immunother Cancer· June 2025

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Poly(adenosine diphosphate ribose) polymerase inhibition in isocitrate dehydrogenase 1 and 2-mutant tumors: Bridging science with the clinic.
Elise Nassif Haddad, Milind M Javle, Timothy A Yap

Cancer· May 2025

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Barriers to publishing early phase clinical trials: the oncologists' perspective.
Merel J J Lucassen, Pedro Bergmann, Olga Husson, Udai Banerji, Bristi Basu, Timothy A Yap, Christina Yap

Oncologist· April 2025

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