Publications by authors named "Agata Copani"

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(±)-2-Cyclohexyl-5-methoxy-2H-chromene, a Synthetic 5-Methoxyflavone Derivative, Is a Selective DNA Polymerase-β Inhibitor with Neuroprotective Activity against β-Amyloid Toxicity.
Salvatore Guccione, Sara Merlo, Silvia Tagliapietra, Matteo Pappalardo, Arianna Binello, Agata Copani

ACS Chem Neurosci· December 2025

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Computational modeling of ATM signaling: a predictive framework for drug repurposing in ataxia-telangiectasia.
Aurora Eliana Merulla, Valentina Di Salvatore, Giorgia Serena Gullotta, Avisa Maleki, Giulia Russo, Agata Copani

NPJ Syst Biol Appl· November 2025

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Red-Light-Photosensitized Tyrosine 10 Nitration of β-Amyloid Diverts the Protein from Forming Toxic Aggregates.
Sarah Basile, Cristina Parisi, Francesco Bellia, Stefania Zimbone, Giuseppe Arrabito, Agata Copani

ACS Chem Neurosci· August 2024

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Increased Heat Pain Tolerance but Hyperalgesia to Tonic Inflammatory Pain in the CRND8 Mouse Model of Alzheimer's Disease.
Sara Merlo, Lara Costa, Santina Chiechio, Carla Letizia Busceti, Lucia Ciranna, Agata Copani

J Alzheimers Dis· October 2023

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Molecular Connections between DNA Replication and Cell Death in β-Amyloid-Treated Neurons.
Filippo Caraci, Annamaria Fidilio, Rosa Santangelo, Giuseppe Caruso, Maria Laura Giuffrida, Agata Copani

Curr Neuropharmacol· July 2023

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β-amyloid monomers drive up neuronal aerobic glycolysis in response to energy stressors.
Rosa Santangelo, Maria Laura Giuffrida, Cristina Satriano, Marianna Flora Tomasello, Stefania Zimbone, Agata Copani

Aging (Albany NY)· July 2021

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Role for Metallothionein-3 in the Resistance of Human U87 Glioblastoma Cells to Temozolomide.
Rosa Santangelo, Enrico Rizzarelli, Agata Copani

ACS Omega· July 2020

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Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia.
Ferdinando Nicoletti, Rosamaria Orlando, Luisa Di Menna, Milena Cannella, Serena Notartomaso, Agata Copani

Front Psychiatry· February 2019

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Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?
Simona Federica Spampinato, Agata Copani, Ferdinando Nicoletti, Maria Angela Sortino, Filippo Caraci

Front Mol Neurosci· November 2018

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A promising connection between BDNF and Alzheimer's disease.
Maria Laura Giuffrida, Agata Copani, Enrico Rizzarelli

Aging (Albany NY)· August 2018

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Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target.
Filippo Caraci, Simona Federica Spampinato, Maria Grazia Morgese, Fabio Tascedda, Maria Grazia Salluzzo, Agata Copani

Pharmacol Res· April 2018

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A New Ratiometric Lysosomal Copper(II) Fluorescent Probe To Map a Dynamic Metallome in Live Cells.
Maria Laura Giuffrida, Giuseppe Trusso Sfrazzetto, Cristina Satriano, Stefania Zimbone, Gaetano A Tomaselli, Agata Copani

Inorg Chem· March 2018

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Amyloid Beta monomers regulate cyclic adenosine monophosphate response element binding protein functions by activating type-1 insulin-like growth factor receptors in neuronal cells.
Stefania Zimbone, Irene Monaco, Fiorenza Gianì, Giuseppe Pandini, Agata G Copani

Aging Cell· February 2018

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Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease.
Filippo Caraci, Ferdinando Nicoletti, Agata Copani

Curr Opin Pharmacol· February 2018

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Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system.
Luisa Di Menna, Max E Joffe, Luisa Iacovelli, Rosamaria Orlando, Craig W Lindsley, Agata Copani

Neuropharmacology· January 2018

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The underexplored question of β-amyloid monomers.
Agata Copani

Eur J Pharmacol· December 2017

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The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders.
Valeria Bruno, Filippo Caraci, Agata Copani, Francesco Matrisciano, Ferdinando Nicoletti

Neuropharmacology· March 2017

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Corrigendum: Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-β Oligomer Formation and Cytotoxicity.
Alessandro Sinopoli, Alessandro Giuffrida, Marianna Flora Tomasello, Maria Laura Giuffrida, Marilisa Leone, Agata Copani

Chembiochem· October 2016

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Fluoxetine Prevents Aβ-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor-β1.
Filippo Caraci, Fabio Tascedda, Sara Merlo, Cristina Benatti, Simona F Spampinato, Agata Copani

Front Pharmacol· October 2016

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Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-β Oligomer Formation and Cytotoxicity.
Alessandro Sinopoli, Alessandro Giuffrida, Marianna Flora Tomasello, Maria Laura Giuffrida, Marilisa Leone, Agata Copani

Chembiochem· August 2016

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The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ß1-42 oligomers in mice.
Gian Marco Leggio, Maria Vincenza Catania, Daniela Puzzo, Michela Spatuzza, Rosalia Pellitteri, Agata Copani

Pharmacol Res· April 2016

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Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity.
Sara Merlo, Livia Basile, Maria Laura Giuffrida, Maria Angela Sortino, Salvatore Guccione, Agata Copani

J Nat Prod· November 2015

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Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1-42)-induced toxicity.
Filippo Caraci, Giuseppe Pappalardo, Livia Basile, Alessandro Giuffrida, Agata Copani

Eur J Pharmacol· October 2015

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Igf1 and Pacap rescue cerebellar granule neurons from apoptosis via a common transcriptional program.
Barbara Maino, Velia D'Agata, Cinzia Severini, Maria T Ciotti, Pietro Calissano, Agata Copani

Cell Death Discov· September 2015

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Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons.
Maria L Giuffrida, Marianna F Tomasello, Giuseppe Pandini, Filippo Caraci, Giuseppe Battaglia, Agata Copani

Front Cell Neurosci· August 2015

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