Publications by authors named "Age Utt"

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nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity.
Laura Sandra Lello, Koen Bartholomeeusen, Sainan Wang, Sandra Coppens, Rennos Fragkoudis, Age Utt

J Virol· September 2021

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Interdomain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity.
Yee-Song Law, Sainan Wang, Yaw Bia Tan, Orion Shih, Age Utt

J Virol· February 2021

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Cross-utilisation of template RNAs by alphavirus replicases.
Laura Sandra Lello, Age Utt, Koen Bartholomeeusen, Sainan Wang, Kai Rausalu

PLoS Pathog· September 2020

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Bortezomib inhibits chikungunya virus replication by interfering with viral protein synthesis.
Parveen Kaur, Laura Sandra Lello, Age Utt, Sujit Krishna Dutta, Andres Merits

PLoS Negl Trop Dis· May 2020

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Sensitivity of Alphaviruses to G3BP Deletion Correlates with Efficiency of Replicase Polyprotein Processing.
Benjamin Götte, Age Utt, Rennos Fragkoudis, Andres Merits, Gerald M McInerney

J Virol· March 2020

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Design and Use of Chikungunya Virus Replication Templates Utilizing Mammalian and Mosquito RNA Polymerase I-Mediated Transcription.
Age Utt, Kai Rausalu, Madis Jakobson, Andres Männik, Luke Alphey

J Virol· September 2019

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VCP/p97 Is a Proviral Host Factor for Replication of Chikungunya Virus and Other Alphaviruses.
Guillaume Carissimo, Yi-Hao Chan, Age Utt, Tze-Kwang Chua, Farhana Abu Bakar

Front Microbiol· September 2019

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Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate.
Yi-Hao Chan, Teck-Hui Teo, Age Utt, Jeslin Jl Tan, Siti Naqiah Amrun

EMBO Mol Med· June 2019

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Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase.
Yee-Song Law, Age Utt, Yaw Bia Tan, Jie Zheng, Sainan Wang

Proc Natl Acad Sci U S A· May 2019

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ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication.
Rachy Abraham, Debra Hauer, Robert Lyle McPherson, Age Utt, Ilsa T Kirby

Proc Natl Acad Sci U S A· October 2018

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Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs.
Xiang Liu, Margit Mutso, Age Utt, Anni Lepland, Lara J Herrero

mBio· August 2018

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A Chikungunya Virus -Replicase System Reveals the Importance of Delayed Nonstructural Polyprotein Processing for Efficient Replication Complex Formation in Mosquito Cells.
Koen Bartholomeeusen, Age Utt, Sandra Coppens, Kai Rausalu, Katleen Vereecken

J Virol· July 2018

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Partially Uncleaved Alphavirus Replicase Forms Spherule Structures in the Presence and Absence of RNA Template.
Kirsi Hellström, Katri Kallio, Age Utt, Tania Quirin, Eija Jokitalo

J Virol· September 2017

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Design and Validation of Novel Chikungunya Virus Protease Inhibitors.
Pratyush Kumar Das, Laura Puusepp, Finny S Varghese, Age Utt, Tero Ahola

Antimicrob Agents Chemother· December 2016

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Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease's active site cysteine residue.
Kai Rausalu, Age Utt, Tania Quirin, Finny S Varghese, Eva Žusinaite

Sci Rep· November 2016

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Correction for Utt et al., Mutations Conferring a Noncytotoxic Phenotype on Chikungunya Virus Replicons Compromise Enzymatic Properties of Nonstructural Protein 2.
Age Utt, Pratyush Kumar Das, Margus Varjak, Valeria Lulla, Aleksei Lulla

J Virol· September 2016

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Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein.
Age Utt, Tania Quirin, Sirle Saul, Kirsi Hellström, Tero Ahola

PLoS One· August 2016

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Correction for Thaa et al., Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization.
Bastian Thaa, Roberta Biasiotto, Kai Eng, Maarit Neuvonen, Benjamin Götte, Age Utt

J Virol· April 2016

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Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization.
Bastian Thaa, Roberta Biasiotto, Kai Eng, Maarit Neuvonen, Benjamin Götte, Age Utt

J Virol· November 2015

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Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2.
Age Utt, Pratyush Kumar Das, Margus Varjak, Valeria Lulla, Aleksei Lulla

J Virol· March 2015

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RIG-I and MDA-5 detection of viral RNA-dependent RNA polymerase activity restricts positive-strand RNA virus replication.
Andrei Nikonov, Tarmo Mölder, Rein Sikut, Kaja Kiiver, Andres Männik, Age Utt

PLoS Pathog· April 2014

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Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays.
Leena Pohjala, Age Utt, Margus Varjak, Aleksei Lulla, Andres Merits

PLoS One· April 2012

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