Publications by authors named "Aharon Helman"

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Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling.
Saar Krell, Amit Hamburg, Ofer Gover, Kfir Molakandov, Gil Leibowitz, Aharon Helman

Cell Rep· May 2025

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Hyperglucagonaemia in diabetes: altered amino acid metabolism triggers mTORC1 activation, which drives glucagon production.
Yael Riahi, Aviram Kogot-Levin, Liat Kadosh, Bella Agranovich, Assaf Malka, Aharon Helman

Diabetologia· October 2023

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An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination.
Danna Sheinboim, Shivang Parikh, Paulee Manich, Irit Markus, Sapir Dahan, Aharon Helman

Cancer Res· November 2022

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Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine.
Andrew L Cangelosi, Anna M Puszynska, Justin M Roberts, Andrea Armani, Thao P Nguyen, Aharon Helman

Science· July 2022

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A Stem Cell Approach to Cure Type 1 Diabetes.
Aharon Helman, Douglas A Melton

Cold Spring Harb Perspect Biol· January 2021

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A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion.
Aharon Helman, Andrew L Cangelosi, Jeffrey C Davis, Quan Pham, Arielle Rothman

Cell Metab· May 2020

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Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis.
Jeffrey C Davis, Tiago C Alves, Aharon Helman, Jonathan C Chen, Jennifer H Kenty

Cell Rep· May 2020

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Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence.
Jessica C Garbern, Aharon Helman, Rebecca Sereda, Mohsen Sarikhani, Aishah Ahmed

Circulation· January 2020

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Circadian Entrainment Triggers Maturation of Human In Vitro Islets.
Juan R Alvarez-Dominguez, Julie Donaghey, Niloofar Rasouli, Jennifer H R Kenty, Aharon Helman

Cell Stem Cell· January 2020

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Live Cell Monitoring and Enrichment of Stem Cell-Derived β Cells Using Intracellular Zinc Content as a Population Marker.
Jeffrey C Davis, Aharon Helman, José Rivera-Feliciano, Christine M Langston, Elise N Engquist

Curr Protoc Stem Cell Biol· December 2019

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Postnatal Exocrine Pancreas Growth by Cellular Hypertrophy Correlates with a Shorter Lifespan in Mammals.
Shira Anzi, Miri Stolovich-Rain, Agnes Klochendler, Ori Fridlich, Aharon Helman

Dev Cell· June 2018

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Novel interplay between JNK and Egfr signaling in Drosophila dorsal closure.
Tatyana Kushnir, Sharon Mezuman, Shaked Bar-Cohen, Rotem Lange, Ze'ev Paroush, Aharon Helman

PLoS Genet· June 2017

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The Genetic Program of Pancreatic β-Cell Replication In Vivo.
Agnes Klochendler, Inbal Caspi, Noa Corem, Maya Moran, Oriel Friedlich, Aharon Helman

Diabetes· July 2016

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p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.
Aharon Helman, Agnes Klochendler, Narmen Azazmeh, Yael Gabai, Elad Horwitz

Nat Med· April 2016

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Dynamics of senescent cell formation and retention revealed by p14ARF induction in the epidermis.
Ronit Tokarsky-Amiel, Narmen Azazmeh, Aharon Helman, Yan Stein, Alia Hassan

Cancer Res· May 2013

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RTK signaling modulates the Dorsal gradient.
Aharon Helman, Bomyi Lim, María José Andreu, Yoosik Kim, Tatyana Shestkin

Development· August 2012

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Phosphorylation of Ind by MAP kinase enhances Ind-dependent transcriptional repression.
Cade Moses, Aharon Helman, Ze'ev Paroush, Tonia Von Ohlen

Dev Biol· December 2011

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Phosphorylation of Groucho mediates RTK feedback inhibition and prolonged pathway target gene expression.
Aharon Helman, Einat Cinnamon, Sharon Mezuman, Zvi Hayouka, Tonia Von Ohlen

Curr Biol· July 2011

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Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila.
Leiore Ajuria, Claudia Nieva, Clint Winkler, Dennis Kuo, Núria Samper, Aharon Helman

Development· March 2011

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Detection of RTK pathway activation in Drosophila using anti-dpERK immunofluorescence staining.
Aharon Helman, Ze'ev Paroush

Methods Mol Biol· December 2010

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Multiple RTK pathways downregulate Groucho-mediated repression in Drosophila embryogenesis.
Einat Cinnamon, Aharon Helman, Rachel Ben-Haroush Schyr, Amir Orian, Gerardo Jiménez

Development· March 2008

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Heparanase improves mouse embryo implantation.
Ariel Revel, Aharon Helman, Moriah Koler, Asher Shushan, Orit Goldshmidt

Fertil Steril· March 2005

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Capicua integrates input from two maternal systems in Drosophila terminal patterning.
Einat Cinnamon, Devorah Gur-Wahnon, Aharon Helman, Daniel St Johnston, Gerardo Jiménez

EMBO J· November 2004

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Mouse embryos generated from frozen-thawed oocytes can successfully survive a second cryopreservation.
Ariel Revel, Naama Moshe, Aharon Helman, Anat Safran, Alex Simon

Hum Reprod· March 2004

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