Publications by authors named "Aimee Crombie"

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Delta opioid receptor agonists are effective for multiple types of headache disorders.
Laura S Moye, Alycia F Tipton, Isaac Dripps, Zoie Sheets, Aimee Crombie

Neuropharmacology· April 2019

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TRV0109101, a G Protein-Biased Agonist of the -Opioid Receptor, Does Not Promote Opioid-Induced Mechanical Allodynia following Chronic Administration.
Michael Koblish, Richard Carr, Edward R Siuda, David H Rominger, William Gowen-MacDonald, Aimee L Crombie

J Pharmacol Exp Ther· August 2017

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Biased ligands at G-protein-coupled receptors: promise and progress.
Jonathan D Violin, Aimee L Crombie, David G Soergel, Michael W Lark

Trends Pharmacol Sci· July 2014

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Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain.
Xiao-Tao Chen, Philip Pitis, Guodong Liu, Catherine Yuan, Dimitar Gotchev, Aimee L Crombie

J Med Chem· October 2013

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Synthesis of polycyclic benzofused nitrogen heterocycles via a tandem ynamide benzannulation/ring-closing metathesis strategy. Application in a formal total synthesis of (+)-FR900482.
Xiao Yin Mak, Aimee L Crombie, Rick L Danheiser

J Org Chem· March 2011

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Synthesis and biological evaluation of tricyclic anilinopyrimidines as IKKbeta inhibitors.
Aimee L Crombie, Fuk-Wah Sum, Dennis W Powell, Darrin W Hopper, Nancy Torres

Bioorg Med Chem Lett· June 2010

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Synthesis and evaluation of azabicyclo[3.2.1]octane derivatives as potent mixed vasopressin antagonists.
Aimee L Crombie, Thomas M Antrilli, Brandon A Campbell, David L Crandall, Amedeo A Failli

Bioorg Med Chem Lett· June 2010

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Ring expansion-annulation strategy for the synthesis of substituted azulenes and oligoazulenes. 2. Synthesis of azulenyl halides, sulfonates, and azulenylmetal compounds and their application in transition-metal-mediated coupling reactions.
Aimee L Crombie, John L Kane, Kevin M Shea, Rick L Danheiser

J Org Chem· December 2004

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