Publications by authors named "Akio Ojida"

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Real-time fluorescent and microscopic uricase assay by monitoring the clearance of acridine orange-doped monosodium urate crystals under physiological conditions.
Peeradon Duangiad, Nutsara Mekjinda, Waralee Srinarawat, Thawatchai Chaijarasphong, Noppawan Phumala Morales, Akio Ojida

J Pharm Biomed Anal· November 2025

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β-Fluorovinylsulfonamide as a Highly Reactivity- and Structure-Tunable Electrophile for Covalent Targeting of Proteins.
Shunsuke Watanabe, Keisuke Tokunaga, Yudai Tanaka, Yuya Hirose, Emi Mishiro-Sato, Akio Ojida

J Am Chem Soc· October 2025

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Backbone cleavage of peptides and proteins cysteine -fluoroacetylation.
Yuya Matsumoto, Naoki Zenmyo, Shunsuke Watanabe, Kaori Sasaki-Tabata, Shohei Uchinomiya, Akio Ojida

Chem Commun (Camb)· July 2025

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Etomoxir suppresses the expression of PPARγ2 and inhibits the thermogenic gene induction of brown adipocytes through pathways other than β-oxidation inhibition.
Hiroki Shimura, Sota Yamamoto, Isshin Shiiba, Mami Oikawa, Shohei Uchinomiya, Akio Ojida

J Biochem· March 2025

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A Protein Cleavage Platform Based on Selective Formylation at Cysteine Residues.
Naoki Zenmyo, Yuya Matsumoto, Akihiro Yasuda, Shohei Uchinomiya, Naoya Shindo, Akio Ojida

J Am Chem Soc· January 2025

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Inhibition of dynamin-related protein 1-filamin interaction improves systemic glucose metabolism.
Yuri Kato, Kohei Ariyoshi, Yasunobu Nohara, Naoya Matsunaga, Tsukasa Shimauchi, Akio Ojida

Br J Pharmacol· November 2024

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Generation of a Nonbilayer Lipid Nanoenvironment after Epitope Binding Potentiates Neutralizing HIV-1 MPER Antibody.
Sara Insausti, Ander Ramos-Caballero, Brian Wiley, Saul González-Resines, Johana Torralba, Akio Ojida

ACS Appl Mater Interfaces· November 2024

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Hericenone C attenuates the second phase of formalin-induced nociceptive behavior by suppressing the accumulation of CD11c-positive cells in the paw epidermis via phosphorylated P65.
Junhao Li, Kengo Hamamura, Yuya Yoshida, Shimpei Kawano, Shohei Uchinomiya, Akio Ojida

Biochem Biophys Res Commun· August 2024

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Endogenous activation of peroxisome proliferator-activated receptor-α in proximal tubule cells in counteracting phosphate toxicity.
Yusuke Katsuma, Isao Matsui, Ayumi Matsumoto, Hiroki Okushima, Atsuhiro Imai, Akio Ojida

Am J Physiol Renal Physiol· August 2024

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Oxidized-LDL Induces Metabolic Dysfunction in Retinal Pigment Epithelial Cells.
Manami Tomomatsu, Naoto Imamura, Hoshimi Izumi, Masatsugu Watanabe, Masataka Ikeda, Akio Ojida

Biol Pharm Bull· March 2024

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Naturally occurring quercetin and myricetin as potent inhibitors for human ectonucleotide pyrophosphatase/phosphodiesterase 1.
Peeradon Duangiad, Bodee Nutho, Thawatchai Chaijarasphong, Noppawan Phumala Morales, Thunyarat Pongtharangkul, Akio Ojida

Sci Rep· January 2024

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Spatiotemporally quantitative in vivo imaging of mitochondrial fatty acid β-oxidation at cellular-level resolution in mice.
Ayumi Matsumoto, Isao Matsui, Shohei Uchinomiya, Yusuke Katsuma, Seiichi Yasuda, Akio Ojida

Am J Physiol Endocrinol Metab· November 2023

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Inhibition of Tumor-Derived C-C Motif Chemokine Ligand 2 Expression Attenuates Tactile Allodynia in NCTC 2472 Fibrosarcoma-Inoculated Mice.
Marie Taniguchi, Sai Yasukochi, Wakaba Yamakawa, Yuya Tsurudome, Akito Tsuruta, Akio Ojida

Mol Pharmacol· August 2023

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Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting of Cysteines.
Daiki Yamane, Ryo Tetsukawa, Naoki Zenmyo, Kaori Tabata, Yuya Yoshida, Akio Ojida

J Med Chem· July 2023

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Improved polarized light microscopic detection of gouty crystals via dissolution with formalin and ethylenediamine tetraacetic acid.
Ruedee Hemstapat, Peeradon Duangiad, Borwornporn Tangketsarawan, Thitiya Phuagpan, Sinthida Chienwiwattanawong, Akio Ojida

Sci Rep· May 2023

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Fluorescence-Based Detection of Fatty Acid β-Oxidation in Cells and Tissues Using Quinone Methide-Releasing Probes.
Shohei Uchinomiya, Tomoki Nagaura, Mark Weber, Yuya Matsuo, Naoki Zenmyo, Akio Ojida

J Am Chem Soc· April 2023

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Fluorescence identification of arthropathic calcium pyrophosphate single crystals using alizarin red S and a xanthene dipicolylamine Zn complex.
Waralee Srinarawat, Ruedee Hemstapat, Tulyapruek Tawonsawatruk, Nisa Patikarnmonthon, Itaru Hamachi, Akio Ojida

Analyst· October 2022

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Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease.
Yuya Hirose, Naoya Shindo, Makiko Mori, Satsuki Onitsuka, Hikaru Isogai, Akio Ojida

J Med Chem· October 2022

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[Covalent drug discovery exploiting the new warheads].
Akio Ojida

Nihon Yakurigaku Zasshi· September 2022

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Spontaneously Recycling Synaptic Vesicles Constitute Readily Releasable Vesicles in Intact Neuromuscular Synapses.
Yoshihiro Egashira, Ayane Kumade, Akio Ojida, Fumihito Ono

J Neurosci· April 2022

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Selective covalent targeting of SARS-CoV-2 main protease by enantiopure chlorofluoroacetamide.
Daiki Yamane, Satsuki Onitsuka, Suyong Re, Hikaru Isogai, Rui Hamada, Akio Ojida

Chem Sci· March 2022

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Recent progress in covalent warheads for in vivo targeting of endogenous proteins.
Naoya Shindo, Akio Ojida

Bioorg Med Chem· October 2021

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A multicolor and ratiometric fluorescent sensing platform for metal ions based on arene-metal-ion contact.
Anna Kanegae, Yusuke Takata, Ippei Takashima, Shohei Uchinomiya, Ryosuke Kawagoe, Akio Ojida

Commun Chem· July 2021

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Fragment-Based Discovery of Irreversible Covalent Inhibitors of Cysteine Proteases Using Chlorofluoroacetamide Library.
Chizuru Miura, Naoya Shindo, Kei Okamoto, Keiko Kuwata, Akio Ojida

Chem Pharm Bull (Tokyo)· May 2021

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Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins.
Keisuke Tokunaga, Mami Sato, Keiko Kuwata, Chizuru Miura, Hirokazu Fuchida, Akio Ojida

J Am Chem Soc· October 2020

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