Publications by authors named "Isshin Shiiba"

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Etomoxir suppresses the expression of PPARγ2 and inhibits the thermogenic gene induction of brown adipocytes through pathways other than β-oxidation inhibition.
Hiroki Shimura, Sota Yamamoto, Isshin Shiiba, Mami Oikawa, Shohei Uchinomiya

J Biochem· March 2025

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ER-mitochondria contacts mediate lipid radical transfer via RMDN3/PTPIP51 phosphorylation to reduce mitochondrial oxidative stress.
Isshin Shiiba, Naoki Ito, Hijiri Oshio, Yuto Ishikawa, Takahiro Nagao

Nat Commun· February 2025

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Intracellular tau fragment droplets serve as seeds for tau fibrils.
Yoshiyuki Soeda, Hideaki Yoshimura, Hiroko Bannai, Riki Koike, Isshin Shiiba

Structure· October 2024

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Ubiquitin-mediated mitochondrial regulation by MITOL/MARCHF5 at a glance.
Shun Nagashima, Naoki Ito, Isshin Shiiba, Hiroki Shimura, Shigeru Yanagi

J Biochem· December 2022

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Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation.
Takeshi Tokuyama, Hideki Uosaki, Ayumu Sugiura, Gen Nishitai, Keisuke Takeda, Isshin Shiiba

iScience· July 2022

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MITOL regulates phosphatidic acid-binding activity of RMDN3/PTPIP51.
Naoki Ito, Takara Takahashi, Isshin Shiiba, Shun Nagashima, Ryoko Inatome

J Biochem· May 2022

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Forebrain-specific deficiency of the GTPase CRAG/Centaurin-γ3 leads to immature dentate gyri and hyperactivity in mice.
Shun Nagashima, Naoki Ito, Reiki Kobayashi, Isshin Shiiba, Hiroki Shimura

J Biol Chem· August 2021

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MITOL promotes cell survival by degrading Parkin during mitophagy.
Isshin Shiiba, Keisuke Takeda, Shun Nagashima, Naoki Ito, Takeshi Tokuyama

EMBO Rep· March 2021

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Mitochondrial ubiquitin ligase alleviates Alzheimer's disease pathology via blocking the toxic amyloid-β oligomer generation.
Keisuke Takeda, Aoi Uda, Mikihiro Mitsubori, Shun Nagashima, Hiroko Iwasaki, Isshin Shiiba

Commun Biol· February 2021

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MITOL dysfunction causes dwarfism with anterior pituitary hypoplasia.
Keigo Matsuno, Shun Nagashima, Isshin Shiiba, Keito Taniwaka, Keisuke Takeda

J Biochem· September 2020

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Overview of Mitochondrial E3 Ubiquitin Ligase MITOL/MARCH5 from Molecular Mechanisms to Diseases.
Isshin Shiiba, Keisuke Takeda, Shun Nagashima, Shigeru Yanagi

Int J Mol Sci· May 2020

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Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients.
Takeshi Tokuyama, Asei Hirai, Isshin Shiiba, Naoki Ito, Keigo Matsuno

Biomolecules· March 2020

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Critical role of CRAG, a splicing variant of centaurin-γ3/AGAP3, in ELK1-dependent SRF activation at PML bodies.
Shun Nagashima, Keisuke Takeda, Isshin Shiiba, Mizuho Higashi, Toshifumi Fukuda

Sci Rep· December 2019

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MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites.
Keisuke Takeda, Shun Nagashima, Isshin Shiiba, Aoi Uda, Takeshi Tokuyama

EMBO J· August 2019

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