Publications by authors named "Alaa Elwan"

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Identification of Benzenesulfonamide-Containing Thiazolidine-2,4-Dione Derivatives as Novel Carbonic Anhydrase II and VII Inhibitors with Anti-Epileptic Activity.
Mohamed M Eldesouki, Mahmoud Abdelrahman Alkabbani, Mohammed S Taghour, Andrea Ammara, Diaaeldin M Elimam, Alaa Elwan

J Med Chem· December 2025

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Evaluation of oxadiazole--phenylacetamide conjugates as VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative assessment, molecular docking, and dynamics studies.
Islam I Otify, Rezk R A Ayyad, Ismail Celik, Helmy Sakr, Alaa Elwan

Future Med Chem· November 2025

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Design, synthesis, and cytotoxic evaluation of quinazoline-based derivatives as VEGER-2 inhibitors: comparative study against EGFR kinase activity, induction of apoptosis, and molecular docking study.
Reda R Mabrouk, Arafa Musa, Maged Mohammed Saleh Al Ward, Shaimaa Hussein, Ahmed K B Aljohani, Alaa Elwan

RSC Adv· August 2025

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Identification of Potential FDA-Approved Inhibitors of SARS-CoV-2 Helicase Through a Multistep Approach: A Promising Prospect for COVID-19 Treatment.
Ibrahim H Eissa, Eslam B Elkaeed, Alaa Elwan, Aisha A Alsfouk, Ahmed M Metwaly

Med Chem· June 2025

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Targeting VEGFR-2 in breast cancer: synthesis and and characterization of quinoxaline-based inhibitors.
Ibrahim H Eissa, Alaa Elwan, Mustafa A Al-Qadhi, Dalal Z Husein, Fatma G Amin

RSC Adv· April 2025

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New nicotinamide derivatives as potential anticancer agents targeting VEGFR-2: design, synthesis, , and studies.
Reda G Yousef, Ibrahim H Eissa, Hazem Elkady, Wagdy M Eldehna, Ahmed B M Mehany, Alaa Elwan

J Biomol Struct Dyn· March 2025

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Design and synthesis of new nicotinamides as immunomodulatory VEGFR-2 inhibitors and apoptosis inducers.
Reda G Yousef, Ibrahim H Eissa, Hazem Elkady, Ahmed B M Mehany, Mariam Ali Abo-Saif, Alaa Elwan

Future Med Chem· December 2024

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New thiazolidine-2,4-diones as potential anticancer agents and apoptotic inducers targeting VEGFR-2 kinase: Design, synthesis, in silico and in vitro studies.
Hazem Elkady, Hazem A Mahdy, Mohammed S Taghour, Mohammed A Dahab, Alaa Elwan

Biochim Biophys Acta Gen Subj· June 2024

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Semi-synthesized anticancer theobromine derivatives targeting VEGFR-2: and evaluations.
Mohammed A Dahab, Hazem A Mahdy, Hazem Elkady, Mohammed S Taghour, Alaa Elwan

J Biomol Struct Dyn· May 2024

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Discovery of new thiazolidine-2,4-dione derivatives as potential VEGFR-2 inhibitors: and studies.
Ibrahim H Eissa, Hazem Elkady, Mahmoud Rashed, Alaa Elwan, Mohamed Hagras

Heliyon· January 2024

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New thiazolidine-2,4-diones as effective anti-proliferative and anti-VEGFR-2 agents: Design, synthesis, in vitro, docking, MD simulations, DFT, ADMET, and toxicity studies.
Hazem Elkady, Abdelrahman A Abuelkhir, Mahmoud Rashed, Mohammed S Taghour, Mohammed A Dahab, Alaa Elwan

Comput Biol Chem· December 2023

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Synthesis, biological evaluation and computer-aided discovery of new thiazolidine-2,4-dione derivatives as potential antitumor VEGFR-2 inhibitors.
Hazem Elkady, Osama A El-Dardir, Alaa Elwan, Mohammed S Taghour, Hazem A Mahdy

RSC Adv· September 2023

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New theobromine derivatives inhibiting VEGFR-2: design, synthesis, antiproliferative, docking and molecular dynamics simulations.
Hazem A Mahdy, Hazem Elkady, Mohammed S Taghour, Alaa Elwan, Mohammed A Dahab

Future Med Chem· July 2023

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New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and studies.
Hazem Elkady, Alaa Elwan, Hesham A El-Mahdy, Ahmed S Doghish, Ahmed Ismail

J Enzyme Inhib Med Chem· December 2022

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Triazoloquinoxalines-based DNA intercalators-Topo II inhibitors: design, synthesis, docking, ADMET and anti-proliferative evaluations.
Alaa Elwan, Helmy Sakr, Abdel-Ghany A El-Helby, Ahmed El-Morsy, Mohamed A Abdelgawad

J Enzyme Inhib Med Chem· December 2022

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Design, synthesis, molecular modeling and biological evaluation of novel Benzoxazole-Benzamide conjugates a 2-Thioacetamido linker as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers.
Ibrahim H Eissa, Radwan El-Haggar, Mohammed A Dahab, Marwa F Ahmed, Hazem A Mahdy, Alaa Elwan

J Enzyme Inhib Med Chem· December 2022

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Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, studies, and antiproliferative evaluation.
Mohammed S Taghour, Hazem A Mahdy, Maher H Gomaa, Ahmed Aglan, Mahmoud Gomaa Eldeib, Alaa Elwan

J Enzyme Inhib Med Chem· December 2022

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Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: and studies.
Reda G Yousef, Alaa Elwan, Ibraheem M M Gobaara, Ahmed B M Mehany, Wagdy M Eldehna

J Enzyme Inhib Med Chem· December 2022

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New [1,2,4]triazolo[4,3-c]quinazoline derivatives as vascular endothelial growth factor receptor-2 inhibitors and apoptosis inducers: Design, synthesis, docking, and antiproliferative evaluation.
Ahmed E Azab, Mohamed S Alesawy, Wagdy M Eldehna, Alaa Elwan, Ibrahim H Eissa

Arch Pharm (Weinheim)· October 2022

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Design, synthesis and molecular docking of new [1,2,4] triazolo[4,3-a]quinoxaline derivatives as anticancer agents targeting VEGFR-2 kinase.
Nawaf A Alsaif, Alaa Elwan, Mohammed M Alanazi, Ahmad J Obaidullah, Wael A Alanazi

Mol Divers· August 2022

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Modified Benzoxazole-Based VEGFR-2 Inhibitors and Apoptosis Inducers: Design, Synthesis, and Anti-Proliferative Evaluation.
Alaa Elwan, Abdallah E Abdallah, Hazem A Mahdy, Mohammed A Dahab, Mohammed S Taghour

Molecules· August 2022

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A Multistage In Silico Study of Natural Potential Inhibitors Targeting SARS-CoV-2 Main Protease.
Eslam B Elkaeed, Ibrahim H Eissa, Hazem Elkady, Ahmed Abdelalim, Ahmad M Alqaisi, Alaa Elwan

Int J Mol Sci· July 2022

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Design, Synthesis, In Silico and In Vitro Studies of New Immunomodulatory Anticancer Nicotinamide Derivatives Targeting VEGFR-2.
Reda G Yousef, Wagdy M Eldehna, Alaa Elwan, Abdelaziz S Abdelaziz, Ahmed B M Mehany

Molecules· June 2022

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Targeting VEGFR-2 by new quinoxaline derivatives: Design, synthesis, antiproliferative assay, apoptosis induction, and in silico studies.
Nawaf A Alsaif, Hazem A Mahdy, Mohammed M Alanazi, Ahmad J Obaidullah, Hamad M Alkahtani, Alaa Elwan

Arch Pharm (Weinheim)· February 2022

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Design, synthesis, docking, ADMET studies, and anticancer evaluation of new 3-methylquinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers.
Mohammed M Alanazi, Ibrahim H Eissa, Nawaf A Alsaif, Ahmad J Obaidullah, Wael A Alanazi, Alaa Elwan

J Enzyme Inhib Med Chem· December 2021

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