Publications by authors named "Alain Chion"

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Significance of the amino acid at position 2561 in the C4 domain of von Willebrand factor.
Thomas A J McKinnon, Yi Liu, Fan Gong, Alain Chion, Stephen Rothery

J Thromb Haemost· December 2025

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Enhanced α2-3-linked sialylation determines the extended half-life of CHO-rVWF.
Ciara Byrne, Soracha Ward, Jamie O'Sullivan, Alain Chion, Patricia Lopes

Blood· June 2025

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Probing rare von Willebrand disease-causing mutations in the D4 and C-domains of von Willebrand factor.
Golzar Mobayen, Sammy El-Mansi, Alain Chion, Thomas D Nightingale, Thomas A J McKinnon

Res Pract Thromb Haemost· May 2025

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R1205H (Vicenza) causes conformational changes in the von Willebrand factor D'D3 domains and enhances von Willebrand factor binding to clearance receptors LRP1 and SR-AI.
Ferdows Atiq, Orla Rawley, Jamie M O'Sullivan, Mehmet Özbil, Dearbhla Doherty, Alain Chion

J Thromb Haemost· October 2024

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The aptamer BT200 blocks interaction of K1405-K1408 in the VWF-A1 domain with macrophage LRP1.
Alain Chion, Ciara Byrne, Ferdows Atiq, Dearbhla Doherty, Sonia Aguila

Blood· September 2024

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Macrophage Galactose Lectin Contributes to the Regulation of FVIII (Factor VIII) Clearance in Mice-Brief Report.
Soracha E Ward, Thomas Guest, Ciara Byrne, Patricia Lopes, Jamie M O'Sullivan, Alain Chion

Arterioscler Thromb Vasc Biol· April 2023

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von Willebrand factor links primary hemostasis to innate immunity.
Clive Drakeford, Sonia Aguila, Fiona Roche, Karsten Hokamp, Judicael Fazavana, Alain Chion

Nat Commun· November 2022

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Hemostatic and protein C pathway dysfunction in the pathogenesis of experimental cerebral malaria.
Niamh O'Regan, Kristina Gegenbauer, Eimear M Gleeson, Kenji Fukudome, Jamie M O'Sullivan, Alain Chion

Haematologica· August 2022

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Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin-mediated clearance.
Soracha E Ward, Jamie M O'Sullivan, Alan B Moran, Daniel I R Spencer, Richard A Gardner, Alain Chion

Haematologica· March 2022

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Blocking von Willebrand factor free thiols inhibits binding to collagen under high and pathological shear stress.
Harrison E R O'Brien, X Frank Zhang, Maximo Sanz-Hernandez, Alain Chion, Susan Shapiro

J Thromb Haemost· February 2021

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Investigating the clearance of VWF A-domains using site-directed PEGylation and novel N-linked glycosylation.
Judicael Fazavana, Teresa M Brophy, Alain Chion, Niamh Cooke, Virginie Terraube

J Thromb Haemost· June 2020

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Increased galactose expression and enhanced clearance in patients with low von Willebrand factor.
Sonia Aguila, Michelle Lavin, Niall Dalton, Sean Patmore, Alain Chion

Blood· April 2019

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A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance.
Soracha E Ward, Jamie M O'Sullivan, Clive Drakeford, Sonia Aguila, Christopher N Jondle, Alain Chion

Blood· February 2018

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Plasmin Cleaves Von Willebrand Factor at K1491-R1492 in the A1-A2 Linker Region in a Shear- and Glycan-Dependent Manner In Vitro.
Teresa M Brophy, Soracha E Ward, Thomas R McGimsey, Sonja Schneppenheim, Clive Drakeford, Alain Chion

Arterioscler Thromb Vasc Biol· May 2017

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N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance.
Alain Chion, Jamie M O'Sullivan, Clive Drakeford, Gudmundur Bergsson, Niall Dalton

Blood· October 2016

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Galectin-1 and Galectin-3 Constitute Novel-Binding Partners for Factor VIII.
Jamie M O'Sullivan, P Vince Jenkins, Orla Rawley, Kristina Gegenbauer, Alain Chion

Arterioscler Thromb Vasc Biol· May 2016

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Marked elevation in plasma osteoprotegerin constitutes an early and consistent feature of cerebral malaria.
Niamh O'Regan, Chris Moxon, Kristina Gegenbauer, Jamie M O'Sullivan, Alain Chion

Thromb Haemost· April 2016

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A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria.
Niamh O'Regan, Kristina Gegenbauer, Jamie M O'Sullivan, Sanaz Maleki, Teresa M Brophy, Alain Chion

Blood· March 2016

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A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF.
Sara Zanardelli, Alain C K Chion, Evelyn Groot, Peter J Lenting, Thomas A J McKinnon

Blood· September 2009

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N-linked glycosylation of VWF modulates its interaction with ADAMTS13.
Thomas A J McKinnon, Alain C K Chion, Alexander J Millington, David A Lane, Mike A Laffan

Blood· March 2008

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Autoantibodies to thrombin directed against both of its cryptic exosites.
Luigina Mollica, Roger J S Preston, Alain Chan Kwo Chion, Steve J Lees, Peter Collins

Br J Haematol· February 2006

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