Publications by authors named "Alain Matagne"

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Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Characterization in Rodent Seizure and Epilepsy Models.
Karine Leclercq, Alain Matagne, Laurent Provins, Henrik Klitgaard, Rafal M Kaminski

J Pharmacol Exp Ther· January 2020

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Brivaracetam does not modulate ionotropic channels activated by glutamate, γ-aminobutyric acid, and glycine in hippocampal neurons.
Isabelle Niespodziany, Jean-Michel Rigo, Gustave Moonen, Alain Matagne, Henrik Klitgaard

Epilepsia· November 2017

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Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus.
Jerome Niquet, Lucie Suchomelova, Kerry Thompson, Henrik Klitgaard, Alain Matagne

Epilepsia· July 2017

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Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatment.
Henrik Klitgaard, Alain Matagne, Jean-Marie Nicolas, Michel Gillard, Yves Lamberty

Epilepsia· April 2016

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Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action.
Jean-Marie Nicolas, Jonas Hannestad, Daniel Holden, Sophie Kervyn, Nabeel Nabulsi, Alain Matagne

Epilepsia· February 2016

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Anti-ictogenic and antiepileptogenic properties of brivaracetam in mature and immature rats.
Nina Dupuis, Alain Matagne, Ludovicus Staelens, Pascal Dournaud, Béatrice Desnous

Epilepsia· May 2015

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Current understanding of the mechanism of action of the antiepileptic drug lacosamide.
Michael A Rogawski, Azita Tofighy, H Steve White, Alain Matagne, Christian Wolff

Epilepsy Res· February 2015

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Lacosamide treatment following status epilepticus attenuates neuronal cell loss and alterations in hippocampal neurogenesis in a rat electrical status epilepticus model.
Thomas Licko, Natalie Seeger, Christina Zellinger, Vera Russmann, Alain Matagne

Epilepsia· July 2013

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Synergism of lacosamide with established antiepileptic drugs in the 6-Hz seizure model in mice.
Alexey Shandra, Pavel Shandra, Olga Kaschenko, Alain Matagne, Thomas Stöhr

Epilepsia· July 2013

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Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: relationship to anti-convulsant properties.
Michel Gillard, Bruno Fuks, Karine Leclercq, Alain Matagne

Eur J Pharmacol· August 2011

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The acute and chronic effects of the novel anticonvulsant lacosamide in an experimental model of status epilepticus.
Claude G Wasterlain, Thomas Stöhr, Alain Matagne

Epilepsy Res· March 2011

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Discovery of indolone acetamides as novel SV2A ligands with improved potency toward seizure suppression.
Anne Frycia, Jean-Philippe Starck, Sophie Jadot, Bénédicte Lallemand, Karine Leclercq, Alain Matagne

ChemMedChem· February 2010

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Profile of the new pyrrolidone derivative seletracetam (ucb 44212) in animal models of epilepsy.
Alain Matagne, Doru-Georg Margineanu, Heidrun Potschka, Wolfgang Löscher, Philippe Michel

Eur J Pharmacol· July 2009

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Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam.
Rafal M Kaminski, Michel Gillard, Karine Leclercq, Etienne Hanon, Geneviève Lorent, Alain Matagne

Epilepsia· July 2009

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Benefit of combination therapy in epilepsy: a review of the preclinical evidence with levetiracetam.
Rafal M Kaminski, Alain Matagne, Philip N Patsalos, Henrik Klitgaard

Epilepsia· March 2009

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Effects of chronic treatment with levetiracetam on hippocampal field responses after pilocarpine-induced status epilepticus in rats.
Doru-Georg Margineanu, Alain Matagne, Rafal M Kaminski, Henrik Klitgaard

Brain Res Bull· November 2008

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Visualization of SV2A conformations in situ by the use of Protein Tomography.
Berkley A Lynch, Alain Matagne, Annika Brännström, Anne von Euler, Magnus Jansson

Biochem Biophys Res Commun· October 2008

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SV2A protein is a broad-spectrum anticonvulsant target: functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsy.
Rafal M Kaminski, Alain Matagne, Karine Leclercq, Michel Gillard, Philippe Michel

Neuropharmacology· March 2008

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Seletracetam (UCB 44212).
Barbara Bennett, Alain Matagne, Philippe Michel, Michèle Leonard, Miranda Cornet

Neurotherapeutics· January 2007

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The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam.
Berkley A Lynch, Nathalie Lambeng, Karl Nocka, Patricia Kensel-Hammes, Sandra M Bajjalieh, Alain Matagne

Proc Natl Acad Sci U S A· June 2004

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Anticonvulsant effects of levetiracetam and levetiracetam-diazepam combinations in experimental status epilepticus.
Andrey M Mazarati, Roger Baldwin, Henrik Klitgaard, Alain Matagne, Claude G Wasterlain

Epilepsy Res· February 2004

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Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity.
Benoit M Kenda, Alain C Matagne, Patrice E Talaga, Patrick M Pasau, Edmond Differding

J Med Chem· January 2004

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Electrophysiological, neurochemical and regional effects of levetiracetam in the rat pilocarpine model of temporal lobe epilepsy.
Henrik Klitgaard, Alain Matagne, Renee Grimee, Jocelyne Vanneste-Goemaere, Doru-Georg Margineanu

Seizure· March 2003

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Pilocarpine-induced epileptogenesis in the rat: impact of initial duration of status epilepticus on electrophysiological and neuropathological alterations.
Henrik Klitgaard, Alain Matagne, Jocelyne Vanneste-Goemaere, Doru-Georg Margineanu

Epilepsy Res· September 2002

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Use of epileptic animals for adverse effect testing.
Henrik Klitgaard, Alain Matagne, Yves Lamberty

Epilepsy Res· June 2002

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