Publications by authors named "Alan Cowman"

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D
Deconvolution of the On-Target Activity of Plasmepsin V Peptidomimetics in Parasites.
Wenyin Su, William Nguyen, Ghizal Siddiqui, Jerzy M Dziekan, Danushka Marapana, Alan F Cowman

ACS Infect Dis· December 2025

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MK-7602: a potent multi-stage dual-targeting antimalarial.
Paola Favuzza, Josephine Palandri, Manuel de Lera Ruiz, Wendy Bailey, Christopher W Boyce, Alan F Cowman

EBioMedicine· December 2025

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CD44 cross-linking promotes Plasmodium falciparum invasion.
Angel K Kongsomboonvech, Stephen W Scally, Yann Le Guen, Praveesh Valissery, Nichole D Salinas, Alan F Cowman

Nat Commun· December 2025

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Exploration and Characterization of the Antimalarial Activity of Pyrimidine-2,4-Diamines for which Resistance is Mediated by the ABCI3 Transporter.
Mahta Mansouri, Madeline G Dans, Zijun Low, Katie Loi, Kate E Jarman, Alan F Cowman

ChemMedChem· December 2025

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Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug.
Leonie Anton, Wenjing Cheng, Meseret T Haile, Jerzy M Dziekan, David W Cobb, Alan F Cowman

Nat Struct Mol Biol· November 2025

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Evaluating the potential of cross-species neutralization of anti-PfCyRPA and anti-PfRIPR Monoclonal Antibodies.
Noemi Guerra, Kelly A Hagadorn, Megha Nair, Laty Gaye Thiam, Barnabas G Williams, Alan F Cowman

bioRxiv· November 2025

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Functional characterisation of components in two Plasmodium falciparum Cullin-RING-Ligase complexes.
Danushka Marapana, Simon A Cobbold, Michal Pasternak, Gerald J Shami, Stuart A Ralph, Alan F Cowman

Sci Rep· July 2025

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CD44 cross-linking promotes invasion.
Angel K Kongsomboonvech, Stephen W Scally, Yann Le Guen, Praveesh Valissery, Nichole D Salinas, Alan F Cowman

bioRxiv· July 2025

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Structure-activity analysis of imino-pyrimidinone-fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors.
Anthony N Hodder, Brad E Sleebs, Greg Adams, Sina Rezazadeh, Anna Ngo, Alan F Cowman

FEBS J· June 2025

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Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4.
Jon Kyle Awalt, Zi Kang Ooi, Trent D Ashton, Mahta Mansouri, Petar P S Calic, Alan F Cowman

J Med Chem· April 2025

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PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes.
Alan Cowman, Benjamin Seager, Pailene Lim, Keng-Heng Lai, Lionel Feufack-Donfack

Res Sq· April 2025

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PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of species into erythrocytes.
Benjamin A Seager, Pailene S Lim, Keng Heng Lai, Lionel Brice Feufack-Donfack, Sheena Dass, Alan F Cowman

bioRxiv· March 2025

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Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4.
Trent D Ashton, Petar P S Calic, Madeline G Dans, Zi Kang Ooi, Qingmiao Zhou, Alan F Cowman

ChemMedChem· December 2024

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E
Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b.
Jon Kyle Awalt, Wenyin Su, William Nguyen, Katie Loi, Kate E Jarman, Alan F Cowman

Eur J Med Chem· December 2024

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Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3.
Petar P S Calic, Trent D Ashton, Mahta Mansouri, Katie Loi, Kate E Jarman, Alan F Cowman

Eur J Med Chem· October 2024

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Author Correction: Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1.
Madeline G Dans, Coralie Boulet, Gabrielle M Watson, William Nguyen, Jerzy M Dziekan, Alan F Cowman

Nat Commun· September 2024

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Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4.
Trent D Ashton, Petar P S Calic, Madeline G Dans, Zi Kang Ooi, Qingmiao Zhou, Alan F Cowman

J Med Chem· August 2024

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Flp/-mediated disruption of and in sporozoites inhibits liver-stage development.
Robyn McConville, Jelte M M Krol, Ryan W J Steel, Matthew T O'Neill, Bethany K Davey, Alan F Cowman

Proc Natl Acad Sci U S A· July 2024

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Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1.
Madeline G Dans, Coralie Boulet, Gabrielle M Watson, William Nguyen, Jerzy M Dziekan, Alan F Cowman

Nat Commun· June 2024

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Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein.
William Nguyen, Coralie Boulet, Madeline G Dans, Katie Loi, Kate E Jarman, Alan F Cowman

Eur J Med Chem· April 2024

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Reticulocyte Binding Protein Homologue 5 is a target of balancing selection in the population of Papua New Guinea.
Myo T Naung, Elijah Martin, Wilson Wong, Zahra Razook, Digjaya Utama, Alan F Cowman

Front Parasitol· December 2023

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Chemo-proteomics in antimalarial target identification and engagement.
Brodie L Bailey, William Nguyen, Alan F Cowman, Brad E Sleebs

Med Res Rev· November 2023

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Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasion.
Tony Triglia, Stephen W Scally, Benjamin A Seager, Michał Pasternak, Laura F Dagley, Alan F Cowman

Nat Commun· April 2023

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Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.
Trent D Ashton, Madeline G Dans, Paola Favuzza, Anna Ngo, Adele M Lehane, Alan F Cowman

J Med Chem· March 2023

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7--Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome Complex.
William Nguyen, Madeline G Dans, Iain Currie, Jon Kyle Awalt, Brodie L Bailey, Alan F Cowman

ACS Infect Dis· March 2023

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