Publications by authors named "Alan Deese"

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Elucidating the structure and cytochrome P450-mediated mechanism for novel metabolites of GDC-0575 in rats.
Chenghong Zhang, Sungjoon Cho, José G Napolitano, David Russell, Christine Gu, Alan Deese

Xenobiotica· March 2022

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Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-Kinase (PI3K) inhibitor, in rats, dogs, and humans.
Qin Yue, S Cyrus Khojasteh, Sungjoon Cho, Shuguang Ma, Teresa Mulder, Alan Deese

Xenobiotica· July 2021

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Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole.
Molly Lin, Justin Ly, Ryan Takahashi, John Chen, Alan Deese

Xenobiotica· October 2018

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Solid-State Characterization of Novel Propylene Glycol Ester Solvates Isolated from Lipid Formulations.
Paroma Chakravarty, Sanjeev Kothari, Alan Deese, Joseph W Lubach

Mol Pharm· July 2015

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Elucidating the mechanism of cytochrome P450-mediated pyrimidine ring conversion to pyrazole metabolites with the BACE1 inhibitor GNE-892 in rats.
Ryan Takahashi, Shuguang Ma, Alan Deese, Qin Yue, Heasook Kim-Kang

Drug Metab Dispos· May 2014

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Pharmacokinetics, metabolism, and excretion of [14C]axitinib, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in humans.
Bill J Smith, Yazdi Pithavala, Hai-Zhi Bu, Ping Kang, Brian Hee, Alan J Deese

Drug Metab Dispos· May 2014

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Degradation of a pharmaceutical in HPLC grade methanol containing trace level formaldehyde.
Qiqing Zhong, Sarah Stowers, Nathaniel L Segraves, Kenley K Ngim, Ke Zhang, Alan Deese

Pharm Dev Technol· December 2013

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Chemoselective sp2-sp3 cross-couplings: iron-catalyzed alkyl transfer to dihaloaromatics.
Sushant Malhotra, Pamela S Seng, Stefan G Koenig, Alan J Deese, Kevin A Ford

Org Lett· July 2013

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Strategies for the analysis of highly reactive pinacolboronate esters.
Qiqing Zhong, Kenley K Ngim, Megan Sun, Jane Li, Alan Deese

J Chromatogr A· March 2012

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An isolable acyclic hemiacetal of ansamitocin P-3.
Nathaniel L Segraves, Derrick Yazzie, Alan J Deese

Magn Reson Chem· March 2012

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Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor.
Lichuan Liu, Jason S Halladay, Young Shin, Susan Wong, Melis Coraggio, Alan Deese

Drug Metab Dispos· October 2011

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Novel mechanism for dehalogenation and glutathione conjugation of dihalogenated anilines in human liver microsomes: evidence for ipso glutathione addition.
Chenghong Zhang, Jane R Kenny, Hoa Le, Alan Deese, Kevin A Ford

Chem Res Toxicol· October 2011

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Absorption, distribution, metabolism, and excretion of [¹⁴C]GDC-0449 (vismodegib), an orally active hedgehog pathway inhibitor, in rats and dogs: a unique metabolic pathway via pyridine ring opening.
Qin Yue, Yung-Hsiang Chen, Teresa Mulder, Alan Deese, Ryan Takahashi

Drug Metab Dispos· June 2011

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Formation of a quinoneimine intermediate of 4-fluoro-N-methylaniline by FMO1: carbon oxidation plus defluorination.
James P Driscoll, Ignacio Aliagas, Jennifer J Harris, Jason S Halladay, Sheerin Khatib-Shahidi, Alan Deese

Chem Res Toxicol· May 2010

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Bioactivation of flutamide metabolites by human liver microsomes.
Ping Kang, Deepak Dalvie, Evan Smith, Sue Zhou, Alan Deese

Drug Metab Dispos· July 2008

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Identification of a novel glutathione conjugate of flutamide in incubations with human liver microsomes.
Ping Kang, Deepak Dalvie, Evan Smith, Sue Zhou, Alan Deese

Drug Metab Dispos· July 2007

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In vitro metabolic activation of thiabendazole via 5-hydroxythiabendazole: identification of a glutathione conjugate of 5-hydroxythiabendazole.
Deepak Dalvie, Evan Smith, Alan Deese, Stephen Bowlin

Drug Metab Dispos· April 2006

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Human in vitro glutathionyl and protein adducts of carbamazepine-10,11-epoxide, a stable and pharmacologically active metabolite of carbamazepine.
Hai-Zhi Bu, Ping Kang, Alan J Deese, Ping Zhao, William F Pool

Drug Metab Dispos· December 2005

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