Publications by authors named "Alan Sabirsh"

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The kinetics of endosomal disruption reveal differences in lipid nanoparticle induced cellular toxicity.
Stephanie M Bates, Michael J Munson, Vitor Trovisco, Sara Pereira, Sophie R Miller, Alan Sabirsh

J Control Release· October 2025

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RNA encoded peptide barcodes enable efficient in vivo screening of RNA delivery systems.
Uchechukwu Odunze, Nitin Rustogi, Paul Devine, Lorraine Miller, Sara Pereira, Alan Sabirsh

Nucleic Acids Res· September 2024

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Reply to: Technical challenges of studying the impact of plasma components on the efficacy of lipid nanoparticles for vaccine and therapeutic applications.
Kai Liu, Elisa Lázaro-Ibáñez, Michael Lerche, Daniel Lindén, Anna Salvati, Alan Sabirsh

Nat Commun· May 2024

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Understanding Intracellular Biology to Improve mRNA Delivery by Lipid Nanoparticles.
Morag Rose Hunter, Lili Cui, Benjamin Thomas Porebski, Sara Pereira, Silvia Sonzini, Alan Sabirsh

Small Methods· September 2023

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TECPR1 is activated by damage-induced sphingomyelin exposure to mediate noncanonical autophagy.
Namrita Kaur, Laura Rodriguez de la Ballina, Håvard Styrkestad Haukaas, Maria Lyngaas Torgersen, Maja Radulovic, Alan Sabirsh

EMBO J· September 2023

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Multiomics analysis of naturally efficacious lipid nanoparticle coronas reveals high-density lipoprotein is necessary for their function.
Kai Liu, Ralf Nilsson, Elisa Lázaro-Ibáñez, Hanna Duàn, Tasso Miliotis, Alan Sabirsh

Nat Commun· July 2023

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Precise and systematic end group chemistry modifications on PAMAM and poly(l-lysine) dendrimers to improve cytosolic delivery of mRNA.
Fanny Joubert, Michael J Munson, Alan Sabirsh, Richard M England, Martin Hemmerling

J Control Release· April 2023

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Interaction Kinetics of Individual mRNA-Containing Lipid Nanoparticles with an Endosomal Membrane Mimic: Dependence on pH, Protein Corona Formation, and Lipoprotein Depletion.
Nima Aliakbarinodehi, Audrey Gallud, Mokhtar Mapar, Emelie Wesén, Sahar Heydari, Alan Sabirsh

ACS Nano· December 2022

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SimSearch: A Human-in-The-Loop Learning Framework for Fast Detection of Regions of Interest in Microscopy Images.
Ankit Gupta, Alan Sabirsh, Carolina Wahlby, Ida-Maria Sintorn

IEEE J Biomed Health Inform· August 2022

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Quantitative intracellular retention of delivered RNAs through optimized cell fixation and immunostaining.
Prasath Paramasivam, Martin Stöter, Eloina Corradi, Irene Dalla Costa, Andreas Höijer, Alan Sabirsh

RNA· March 2022

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Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale.
Prasath Paramasivam, Christian Franke, Martin Stöter, Andreas Höijer, Stefano Bartesaghi, Alan Sabirsh

J Cell Biol· February 2022

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Physiology, pathology and the biomolecular corona: the confounding factors in nanomedicine design.
Kai Liu, Anna Salvati, Alan Sabirsh

Nanoscale· February 2022

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Inhibition of SGLT2 Preserves Function and Promotes Proliferation of Human Islets Cells In Vivo in Diabetic Mice.
Daniel Karlsson, Andrea Ahnmark, Alan Sabirsh, Anne-Christine Andréasson, Peter Gennemark

Biomedicines· January 2022

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Extracting quantitative biological information from bright-field cell images using deep learning.
Saga Helgadottir, Benjamin Midtvedt, Jesús Pineda, Alan Sabirsh, Caroline B Adiels

Biophys Rev (Melville)· September 2021

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A Novel Graphene Quantum Dot-Based mRNA Delivery Platform.
Ya Liu, Changhong Zhao, Alan Sabirsh, Lilei Ye, Xiaoqiu Wu

ChemistryOpen· July 2021

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Deep-learning models for lipid nanoparticle-based drug delivery.
Philip J Harrison, Håkan Wieslander, Alan Sabirsh, Johan Karlsson, Victor Malmsjö

Nanomedicine (Lond)· June 2021

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Rapid development of cloud-native intelligent data pipelines for scientific data streams using the HASTE Toolkit.
Ben Blamey, Salman Toor, Martin Dahlö, Håkan Wieslander, Philip J Harrison, Alan Sabirsh

Gigascience· March 2021

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Effect of complexing lipids on cellular uptake and expression of messenger RNA in human skin explants.
Anna K Blakney, Polina Deletic, Paul F McKay, Clément R Bouton, Marianne Ashford, Alan Sabirsh

J Control Release· February 2021

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A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery.
Michael J Munson, Gwen O'Driscoll, Andreia M Silva, Elisa Lázaro-Ibáñez, Audrey Gallud, Alan Sabirsh

Commun Biol· February 2021

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High-Throughput Automation of Endosomolytic Polymers for mRNA Delivery.
David Ulkoski, Michael J Munson, Max E Jacobson, Christian R Palmer, Carcia S Carson, Alan Sabirsh

ACS Appl Bio Mater· February 2021

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Aligned nanofiber scaffolds improve functionality of cardiomyocytes differentiated from human induced pluripotent stem cell-derived cardiac progenitor cells.
Mei Ding, Henrik Andersson, Sofia Martinsson, Alan Sabirsh, Anna Jonebring

Sci Rep· August 2020

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Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function.
Jenny Sandmark, Anna Tigerström, Tomas Akerud, Magnus Althage, Thomas Antonsson, Alan Sabirsh

J Biol Chem· April 2020

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Human iPS-Derived Astroglia from a Stable Neural Precursor State Show Improved Functionality Compared with Conventional Astrocytic Models.
Anders Lundin, Louise Delsing, Maryam Clausen, Piero Ricchiuto, José Sanchez, Alan Sabirsh

Stem Cell Reports· March 2018

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Long noncoding RNAs are dynamically regulated during β-cell mass expansion in mouse pregnancy and control β-cell proliferation in vitro.
Giorgia Sisino, Alex-Xianghua Zhou, Niklas Dahr, Alan Sabirsh, Mangala M Soundarapandian

PLoS One· October 2017

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Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2.
Matias Casás-Selves, Andrew X Zhang, James E Dowling, Stefan Hallén, Aarti Kawatkar, Alan Sabirsh

ChemMedChem· June 2017

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