Publications by authors named "Jenny Sandmark"

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Design of Bicyclic Peptide Tandems Mimicking the Homodimeric GDF15 Protein to Inhibit GDF15-GFRaL-RET Complex Cell Signaling.
Anaïs F M Noisier, Jenny Sandmark, Fredrik Edfeldt, Anna Backmark, Johan Broddefalk

J Med Chem· October 2025

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Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism.
Lena Ripa, Jenny Sandmark, Glyn Hughes, Igor Shamovsky, Anders Gunnarsson

J Med Chem· October 2023

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Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands.
Anna Y Belorusova, Emma Evertsson, Daniel Hovdal, Jenny Sandmark, Emma Bratt

Commun Biol· May 2020

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Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function.
Jenny Sandmark, Anna Tigerström, Tomas Akerud, Magnus Althage, Thomas Antonsson

J Biol Chem· April 2020

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Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain.
Janna M Bigalke, Shintaro Aibara, Robert Roth, Göran Dahl, Euan Gordon, Jenny Sandmark

Sci Adv· July 2019

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Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A Type X (sPLA-X) Inhibitors.
Laurent Knerr, Fabrizio Giordanetto, Peter Nordberg, Daniel Pettersen, Nidhal Selmi, Jenny Sandmark

ACS Med Chem Lett· July 2018

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Design of Selective sPLA-X Inhibitor (-)-2-{2-[Carbamoyl-6-(trifluoromethoxy)-1-indol-1-yl]pyridine-2-yl}propanoic Acid.
Fabrizio Giordanetto, Laurent Knerr, Peter Nordberg, Daniel Pettersen, Nidhal Selmi, Jenny Sandmark

ACS Med Chem Lett· July 2018

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Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.
Jenny Sandmark, Göran Dahl, Linda Öster, Bingze Xu, Patrik Johansson

J Biol Chem· April 2018

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Discovery of AZD2716: A Novel Secreted Phospholipase A (sPLA) Inhibitor for the Treatment of Coronary Artery Disease.
Fabrizio Giordanetto, Daniel Pettersen, Ingemar Starke, Peter Nordberg, Mikael Dahlström, Jenny Sandmark

ACS Med Chem Lett· October 2016

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Creating novel activated factor XI inhibitors through fragment based lead generation and structure aided drug design.
Ola Fjellström, Sibel Akkaya, Hans-Georg Beisel, Per-Olof Eriksson, Karl Erixon, Jenny Sandmark

PLoS One· October 2015

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Discovery of a novel pyrazole series of group X secreted phospholipase A2 inhibitor (sPLA2X) via fragment based virtual screening.
Hongming Chen, Laurent Knerr, Tomas Åkerud, Kenth Hallberg, Linda Öster, Jenny Sandmark

Bioorg Med Chem Lett· November 2014

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Conserved and nonconserved residues in the substrate binding site of 7,8-diaminopelargonic acid synthase from Escherichia coli are essential for catalysis.
Jenny Sandmark, Andrew C Eliot, Kristoffer Famm, Gunter Schneider, Jack F Kirsch

Biochemistry· February 2004

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Structural basis for the inhibition of the biosynthesis of biotin by the antibiotic amiclenomycin.
Jenny Sandmark, Stephane Mann, Andree Marquet, Gunter Schneider

J Biol Chem· November 2002

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The dual-specific active site of 7,8-diaminopelargonic acid synthase and the effect of the R391A mutation.
Andrew C Eliot, Jenny Sandmark, Gunter Schneider, Jack F Kirsch

Biochemistry· October 2002

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