Publications by authors named "Igor Shamovsky"

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Spirocyclopentane as a Novel Scaffold for Potent Ghrelin Receptor Full Agonists.
Cristina Gardelli, Antonio Llinas, Igor Shamovsky, Yao Xiong, Rongfeng Chen

J Med Chem· December 2025

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Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin.
Frank Narjes, Fredrik Edfeldt, Jens Petersen, Linda Öster, Corinne Hamblet, Igor Shamovsky

J Med Chem· February 2024

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Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism.
Lena Ripa, Jenny Sandmark, Glyn Hughes, Igor Shamovsky, Anders Gunnarsson

J Med Chem· October 2023

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Mechanism-Based Insights into Removing the Mutagenicity of Aromatic Amines by Small Structural Alterations.
Igor Shamovsky, Lena Ripa, Frank Narjes, Britta Bonn, Stefan Schiesser

J Med Chem· June 2021

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Fragment-Based Discovery of Novel Allosteric MEK1 Binders.
Paolo Di Fruscia, Fredrik Edfeldt, Igor Shamovsky, Gavin W Collie, Anna Aagaard

ACS Med Chem Lett· February 2021

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Theoretical Studies of the Mechanism of Carbamoylation of Nucleobases by Isocyanates.
Magnus Liljenberg, Lena Ripa, Igor Shamovsky

Chem Res Toxicol· November 2020

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Identification and Optimization of Pyrrolidine Derivatives as Highly Potent Ghrelin Receptor Full Agonists.
Martin Cooper, Antonio Llinas, Peter Hansen, Moya Caffrey, Asim Ray, Igor Shamovsky

J Med Chem· September 2020

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Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease.
Daniel Pettersen, Johan Broddefalk, Hans Emtenäs, Martin A Hayes, Malin Lemurell, Igor Shamovsky

J Med Chem· May 2019

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Identification and Pharmacological Profile of an Indane Based Series of Ghrelin Receptor Full Agonists.
Cristina Gardelli, Hiroki Wada, Asim Ray, Moya Caffrey, Antonio Llinas, Igor Shamovsky

J Med Chem· July 2018

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Theoretical studies of the second step of the nitric oxide synthase reaction: Electron tunneling prevents uncoupling.
Igor Shamovsky, Graham Belfield, Richard Lewis, Frank Narjes, Lena Ripa

J Inorg Biochem· April 2018

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The discovery of a selective and potent A2a agonist with extended lung retention.
Annika B M Åstrand, Eva Lamm Bergström, Hui Zhang, Lena Börjesson, Therese Söderdahl, Igor Shamovsky

Pharmacol Res Perspect· June 2015

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Theoretical studies of the mechanism of N-hydroxylation of primary aromatic amines by cytochrome P450 1A2: radicaloid or anionic?
Lena Ripa, Christine Mee, Peter Sjö, Igor Shamovsky

Chem Res Toxicol· February 2014

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Theoretical studies of chemical reactivity of metabolically activated forms of aromatic amines toward DNA.
Igor Shamovsky, Lena Ripa, Niklas Blomberg, Leif A Eriksson, Peter Hansen

Chem Res Toxicol· October 2012

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Explanation for main features of structure-genotoxicity relationships of aromatic amines by theoretical studies of their activation pathways in CYP1A2.
Igor Shamovsky, Lena Ripa, Lena Börjesson, Christine Mee, Bo Nordén

J Am Chem Soc· October 2011

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Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites.
Igor Shamovsky, Chris de Graaf, Lisa Alderin, Malena Bengtsson, Håkan Bladh

J Med Chem· December 2009

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Overcoming undesirable HERG potency of chemokine receptor antagonists using baseline lipophilicity relationships.
Igor Shamovsky, Stephen Connolly, Laurent David, Svetlana Ivanova, Bo Nordén

J Med Chem· March 2008

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Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA.
Amy Colquhoun, Gail M Lawrance, Igor L Shamovsky, Richard J Riopelle, Gregory M Ross

J Pharmacol Exp Ther· August 2004

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