Publications by authors named "Anna Backmark"

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Design of Bicyclic Peptide Tandems Mimicking the Homodimeric GDF15 Protein to Inhibit GDF15-GFRaL-RET Complex Cell Signaling.
Anaïs F M Noisier, Jenny Sandmark, Fredrik Edfeldt, Anna Backmark, Johan Broddefalk

J Med Chem· October 2025

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A novel long-acting relaxin-2 fusion, AZD3427, improves cardiac performance in non-human primates with cardiac dysfunction.
Monika Papworth, Spoorthy Kulkarni, Madeleine Antonsson, Isabelle Sermadiras, Daniel Hovdal, Anna Backmark

Cardiovasc Res· June 2025

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Quality by Design for Preclinical In Vitro Assay Development.
Jonathan Jones, Bairu Zhang, Xiang Zhang, Peter Konings, Pia Hansson, Anna Backmark

Pharm Stat· April 2025

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Discovery of Clinical Candidate AZD5462, a Selective Oral Allosteric RXFP1 Agonist for Treatment of Heart Failure.
Kenneth L Granberg, Shigeki Sakamaki, Niklas Larsson, Fredrik Bergström, Ryuichi Fuchigami, Anna Backmark

J Med Chem· March 2024

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Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis.
Farida Ahangari, Christine Becker, Daniel G Foster, Maurizio Chioccioli, Meghan Nelson, Anna Backmark

Am J Respir Crit Care Med· December 2022

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The Common H202D Variant in GDF-15 Does Not Affect Its Bioactivity but Can Significantly Interfere with Measurement of Its Circulating Levels.
Yanislava Karusheva, Matthew Ratcliff, Alexander Mörseburg, Peter Barker, Audrey Melvin, Anna Backmark

J Appl Lab Med· October 2022

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Repositioning of a novel GABA-B receptor agonist, AZD3355 (Lesogaberan), for the treatment of non-alcoholic steatohepatitis.
Dipankar Bhattacharya, Christine Becker, Benjamin Readhead, Nicolas Goossens, Jacqueline Novik, Anna Backmark

Sci Rep· October 2021

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Application of High-Throughput Flow Cytometry in Early Drug Discovery: An AstraZeneca Perspective.
Mei Ding, Roger Clark, Catherine Bardelle, Anna Backmark, Tyrrell Norris

SLAS Discov· August 2018

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Insight into factors directing high production of eukaryotic membrane proteins; production of 13 human AQPs in Pichia pastoris.
Fredrik Oberg, Mikael Ekvall, Maria Nyblom, Anna Backmark, Richard Neutze

Mol Membr Biol· May 2009

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Affinity tags can reduce merohedral twinning of membrane protein crystals.
Anna Backmark, Maria Nyblom, Susanna Törnroth-Horsefield, Urszula Kosinska-Eriksson, Kristina Nordén

Acta Crystallogr D Biol Crystallogr· November 2008

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High-resolution x-ray structure of human aquaporin 5.
Rob Horsefield, Kristina Nordén, Maria Fellert, Anna Backmark, Susanna Törnroth-Horsefield

Proc Natl Acad Sci U S A· September 2008

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