Publications by authors named "Alan Seddon"

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Advancements in Targeted Therapies for Colorectal Cancer: Overcoming Challenges and Exploring Future Directions.
Said A Khelwatty, Soozana Puvanenthiran, Alan M Seddon, Izhar Bagwan, Sharadah Essapen

Cancers (Basel)· August 2025

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Expression of EGFRvIII and its co‑expression with wild‑type EGFR, or putative cancer stem cell biomarkers CD44 or EpCAM are associated with poorer prognosis in patients with hepatocellular carcinoma.
Ozlem Sherif, Said A Khelwatty, Izhar Bagwan, Alan M Seddon, Angus Dalgleish

Oncol Rep· December 2024

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The Combination of Afatinib With Dasatinib or Miransertib Results in Synergistic Growth Inhibition of Stomach Cancer Cells.
Tina Al-Janaby, Narmin Nahi, Alan Seddon, Izhar Bagwan, Said Khelwatty

World J Oncol· April 2024

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Detection of high-risk Human Papillomavirus in prostate cancer from a UK based population.
M Yahya Ahmed, Nadia Aziz Salman, Sarbjinder Sandhu, M Okan Cakir, Alan M Seddon

Sci Rep· May 2023

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HER2 Expression Is Predictive of Survival in Cetuximab Treated Patients with Wild Type Metastatic Colorectal Cancer.
Said A Khelwatty, Soozana Puvanenthiran, Sharadah Essapen, Izhar Bagwan, Alan M Seddon

Cancers (Basel)· February 2021

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Synergistic activity of agents targeting growth factor receptors, CDKs and downstream signaling molecules in a panel of pancreatic cancer cell lines and the identification of antagonistic combinations: Implications for future clinical trials in pancreatic cancer.
Tanzeel Khan, Alan M Seddon, Angus G Dalgleish, Said Khelwatty, Nikolaos Ioannou

Oncol Rep· December 2020

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Co-expression and prognostic significance of putative CSC markers CD44, CD133, wild-type EGFR and EGFRvIII in metastatic colorectal cancer.
Said Abdullah Khelwatty, Sharadah Essapen, Izhar Bagwan, Margaret Green, Alan M Seddon

Oncotarget· March 2019

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Co-expression and prognostic significance of the HER family members, EGFRvIII, c-MET, CD44 in patients with ovarian cancer.
Soozana Puvanenthiran, Sharadah Essapen, Ben Haagsma, Izhar Bagwan, Margaret Green, Alan Seddon

Oncotarget· April 2018

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CmeABC Multidrug Efflux Pump Contributes to Antibiotic Resistance and Promotes Campylobacter jejuni Survival and Multiplication in Acanthamoeba polyphaga.
Ana Vieira, Amritha Ramesh, Alan M Seddon, Andrey V Karlyshev

Appl Environ Microbiol· November 2017

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Synergistic effects of various Her inhibitors in combination with IGF-1R, C-MET and Src targeting agents in breast cancer cell lines.
Aryan Stanley, G Hossein Ashrafi, Alan M Seddon, Helmout Modjtahedi

Sci Rep· June 2017

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Potential probiotic-associated traits revealed from completed high quality genome sequence of 3872.
Burhan Lehri, Alan M Seddon, Andrey V Karlyshev

Stand Genomic Sci· February 2017

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The impact of co-expression of wild-type EGFR and its ligands determined by immunohistochemistry for response to treatment with cetuximab in patients with metastatic colorectal cancer.
Said Khelwatty, Sharadah Essapen, Izhar Bagwan, Margaret Green, Alan Seddon

Oncotarget· January 2017

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Impact of the putative cancer stem cell markers and growth factor receptor expression on the sensitivity of ovarian cancer cells to treatment with various forms of small molecule tyrosine kinase inhibitors and cytotoxic drugs.
Soozana Puvanenthiran, Sharadah Essapen, Alan M Seddon, Helmout Modjtahedi

Int J Oncol· November 2016

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YPTB3816 of Yersinia pseudotuberculosis strain IP32953 is a virulence-related metallo-oligopeptidase.
Ali Atas, Alan M Seddon, Donna C Ford, Ian A Cooper, Brendan W Wren

BMC Microbiol· November 2016

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Acquired resistance of pancreatic cancer cells to treatment with gemcitabine and HER-inhibitors is accompanied by increased sensitivity to STAT3 inhibition.
Nikolaos Ioannou, Alan M Seddon, Angus Dalgleish, David Mackintosh, Flavio Solca

Int J Oncol· March 2016

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Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers.
Said A Khelwatty, Sharadah Essapen, Alan M Seddon, Zhen Fan, Helmout Modjtahedi

Br J Cancer· September 2015

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Campylobacter-Acanthamoeba interactions.
Ana Vieira, Alan M Seddon, Andrey V Karlyshev

Microbiology (Reading)· May 2015

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Co-expression of HER family members in patients with Dukes' C and D colon cancer and their impacts on patient prognosis and survival.
Said Abdullah Khelwatty, Sharadah Essapen, Izhar Bagwan, Margaret Green, Alan Michael Seddon

PLoS One· February 2015

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A negative effect of Campylobacter capsule on bacterial interaction with an analogue of a host cell receptor.
Sona Rubinchik, Alan M Seddon, Andrey V Karlyshev

BMC Microbiol· May 2014

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Prognostic significance and targeting of HER family in colorectal cancer.
Said Abdullah Khelwatty, Sharadah Essapen, Alan Michael Seddon, Helmout Modjtahedi

Front Biosci (Landmark Ed)· January 2013

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Treatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells.
Nikolaos Ioannou, Alan M Seddon, Angus Dalgleish, David Mackintosh, Helmout Modjtahedi

BMC Cancer· January 2013

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Expression pattern and targeting of HER family members and IGF-IR in pancreatic cancer.
Nikolaos Ioannou, Alan M Seddon, Angus Dalgleish, David Mackintosh, Helmout Modjtahedi

Front Biosci (Landmark Ed)· June 2012

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Three-dimensional visualisation of developmental stages of an apicomplexan fish blood parasite in its invertebrate host.
Polly M Hayes, David F Wertheim, Nico J Smit, Alan M Seddon, Angela J Davies

Parasit Vectors· November 2011

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Growth response of human colorectal tumour cell lines to treatment with afatinib (BIBW2992), an irreversible erbB family blocker, and its association with expression of HER family members.
Said Abdullah Khelwatty, Sharadah Essapen, Alan M Seddon, Helmout Modjtahedi

Int J Oncol· August 2011

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A new fish haemogregarine from South Africa and its suspected dual transmission with trypanosomes by a marine leech.
Polly M Hayes, Nico J Smit, Alan M Seddon, David F Wertheim, Angela J Davies

Folia Parasitol· December 2006

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