Publications by authors named "Alan Shiels"

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Through the Gateway: A Brief History of Cataract Genetics.
Alan Shiels

Genes (Basel)· June 2024

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A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts Calcium Dynamics in the Lens.
Yuefang Zhou, Thomas M Bennett, Philip A Ruzycki, Zhaohua Guo, Yu-Qing Cao, Alan Shiels

Cells· January 2024

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Whole-exome sequencing prioritizes candidate genes for hereditary cataract in the Emory mouse mutant.
Thomas M Bennett, Yuefang Zhou, Kacie J Meyer, Michael G Anderson, Alan Shiels

G3 (Bethesda)· May 2023

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Charged multivesicular body protein 4b forms complexes with gap junction proteins during lens fiber cell differentiation.
Yuefang Zhou, Thomas M Bennett, Thomas W White, Alan Shiels

FASEB J· April 2023

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Autophagy Requirements for Eye Lens Differentiation and Transparency.
Lisa Brennan, M Joseph Costello, J Fielding Hejtmancik, A Sue Menko, S Amer Riazuddin, Alan Shiels

Cells· February 2023

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Mutation of the EPHA2 Tyrosine-Kinase Domain Dysregulates Cell Pattern Formation and Cytoskeletal Gene Expression in the Lens.
Yuefang Zhou, Thomas M Bennett, Philip A Ruzycki, Alan Shiels

Cells· September 2021

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Inherited cataracts: Genetic mechanisms and pathways new and old.
Alan Shiels, J Fielding Hejtmancik

Exp Eye Res· August 2021

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Mutation of the TRPM3 cation channel underlies progressive cataract development and lens calcification associated with pro-fibrotic and immune cell responses.
Yuefang Zhou, Thomas M Bennett, Alan Shiels

FASEB J· February 2021

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A charged multivesicular body protein (CHMP4B) is required for lens growth and differentiation.
Yuefang Zhou, Thomas M Bennett, Alan Shiels

Differentiation· April 2020

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TRPM3_miR-204: a complex locus for eye development and disease.
Alan Shiels

Hum Genomics· February 2020

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Biology of Inherited Cataracts and Opportunities for Treatment.
Alan Shiels, J Fielding Hejtmancik

Annu Rev Vis Sci· September 2019

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Epha2 and Efna5 participate in lens cell pattern-formation.
Yuefang Zhou, Alan Shiels

Differentiation· November 2018

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Germ-line and somatic EPHA2 coding variants in lens aging and cataract.
Thomas M Bennett, Oussama M'Hamdi, J Fielding Hejtmancik, Alan Shiels

PLoS One· January 2018

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Mutations and mechanisms in congenital and age-related cataracts.
Alan Shiels, J Fielding Hejtmancik

Exp Eye Res· March 2017

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Lens transcriptome profile during cataract development in Mip-null mice.
Thomas M Bennett, Yuefang Zhou, Alan Shiels

Biochem Biophys Res Commun· September 2016

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Lens ER-stress response during cataract development in Mip-mutant mice.
Yuefang Zhou, Thomas M Bennett, Alan Shiels

Biochim Biophys Acta· August 2016

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Exome Sequencing Identifies a Missense Variant in EFEMP1 Co-Segregating in a Family with Autosomal Dominant Primary Open-Angle Glaucoma.
Donna S Mackay, Thomas M Bennett, Alan Shiels

PLoS One· April 2016

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Overview of the Lens.
J Fielding Hejtmancik, Alan Shiels

Prog Mol Biol Transl Sci· February 2016

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Lens Biology and Biochemistry.
J Fielding Hejtmancik, S Amer Riazuddin, Rebecca McGreal, Wei Liu, Ales Cvekl, Alan Shiels

Prog Mol Biol Transl Sci· February 2016

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Molecular Genetics of Cataract.
Alan Shiels, J Fielding Hejtmancik

Prog Mol Biol Transl Sci· February 2016

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Mutation of the melastatin-related cation channel, TRPM3, underlies inherited cataract and glaucoma.
Thomas M Bennett, Donna S Mackay, Carla J Siegfried, Alan Shiels

PLoS One· November 2015

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Role of Aquaporin 0 in lens biomechanics.
S Sindhu Kumari, Neha Gupta, Alan Shiels, Paul G FitzGerald, Anil G Menon

Biochem Biophys Res Commun· July 2015

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Exome sequencing identifies novel and recurrent mutations in GJA8 and CRYGD associated with inherited cataract.
Donna S Mackay, Thomas M Bennett, Susan M Culican, Alan Shiels

Hum Genomics· November 2014

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Aquaporin-0 targets interlocking domains to control the integrity and transparency of the eye lens.
Woo-Kuen Lo, Sondip K Biswas, Lawrence Brako, Alan Shiels, Sumin Gu

Invest Ophthalmol Vis Sci· March 2014

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Noncoding variation of the gene for ferritin light chain in hereditary and age-related cataract.
Thomas M Bennett, Giovanni Maraini, Chongfei Jin, Wenmin Sun, J Fielding Hejtmancik, Alan Shiels

Mol Vis· September 2013

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