Publications by authors named "Alan Shih"

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A novel 3-way translocation involving :: drives AML with eosinophilia.
Ariel Siegel, Joseph Tripodi, Dianna Hardatt, Brianna Kelly, Sebastian El Ghaity-Beckley, Alan H Shih

Blood Neoplasia· May 2025

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CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2- and TET2-mutant Cells.
Michael R Waarts, Shoron Mowla, Meaghan Boileau, Anthony R Martinez Benitez, Junya Sango, Alan H Shih

Cancer Discov· October 2024

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Evaluating the role of Day 14 bone marrow biopsy and European LeukemiaNet risk classification in predicting overall and relapse-free survival in acute myeloid leukemia.
Metodi Balev, Victor Zibara, Grace Van Hyfte, Jonathan Feld, Marina Kremyanskaya, Alan H Shih

Am J Hematol· October 2024

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Discontinuation Syndrome With JAK2 Selective Agents: Case Presentation and Mechanistic Insights.
Shivani Handa, Kyle A Farina, Michelle Becker, Brianna Kelly, Ashley Yu, Alan H Shih

JCO Precis Oncol· January 2024

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Correction: An MDM2 degrader for treatment of acute leukemias.
Bridget K Marcellino, Xiaobao Yang, H Ümit Kaniskan, Claudia Brady, He Chen, Alan H Shih

Leukemia· August 2023

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An MDM2 degrader for treatment of acute leukemias.
Bridget K Marcellino, Xiaobao Yang, H Ümit Kaniskan, Claudia Brady, He Chen, Alan H Shih

Leukemia· February 2023

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Murine Modeling of Myeloproliferative Neoplasms.
Karie Chen, Alan H Shih

Hematol Oncol Clin North Am· April 2021

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Safety and Efficacy: Clinical Experience of Venetoclax in Combination With Hypomethylating Agents in Both Newly Diagnosed and Relapsed/Refractory Advanced Myeloid Malignancies.
Jonathan Feld, Douglas Tremblay, Mikaela Dougherty, Tina Czaplinska, Gillian Sanchez, Alan H Shih

Hemasphere· April 2021

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Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML.
Sheng Li, Xiaowen Chen, Jiahui Wang, Cem Meydan, Jacob L Glass, Alan H Shih

Cancer Discov· December 2020

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Venetoclax and hypomethylating agent combination therapy in acute myeloid leukemia secondary to a myeloproliferative neoplasm.
Douglas Tremblay, Jonathan Feld, Mikaela Dougherty, Tina Czaplinska, Gillian Sanchez, Alan H Shih

Leuk Res· November 2020

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Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML.
Cihangir Duy, Matt Teater, Francine E Garrett-Bakelman, Tak C Lee, Cem Meydan, Alan H Shih

Cancer Discov· July 2019

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Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer.
Dong Chen, Siyuan Xia, Mei Wang, Ruiting Lin, Yuancheng Li, Alan H Shih

Cancer Discov· June 2019

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TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis.
Pilar M Dominguez, Hussein Ghamlouch, Wojciech Rosikiewicz, Parveen Kumar, Wendy Béguelin, Alan H Shih

Cancer Discov· December 2018

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Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition.
James J Harding, Maeve A Lowery, Alan H Shih, Juan M Schvartzman, Shengqi Hou

Cancer Discov· December 2018

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JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition.
Anna Sophia McKenney, Allison N Lau, Amritha Varshini Hanasoge Somasundara, Barbara Spitzer, Andrew M Intlekofer, Alan H Shih

J Clin Invest· October 2018

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Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib.
Lynn Quek, Muriel D David, Alison Kennedy, Marlen Metzner, Michael Amatangelo, Alan Shih

Nat Med· August 2018

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Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations.
Andrew M Intlekofer, Alan H Shih, Bo Wang, Abbas Nazir, Ariën S Rustenburg

Nature· July 2018

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JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition.
Anna Sophia McKenney, Allison N Lau, Amritha Varshini Hanasoge Somasundara, Barbara Spitzer, Andrew M Intlekofer, Alan H Shih

J Clin Invest· February 2018

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Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity.
Hiroyoshi Kunimoto, Cem Meydan, Abbas Nazir, Justin Whitfield, Kaitlyn Shank, Alan H Shih

Cancer Cell· January 2018

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Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response.
Michael D Amatangelo, Lynn Quek, Alan Shih, Eytan M Stein, Mikhail Roshal

Blood· August 2017

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Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in - and -Mutant Acute Myeloid Leukemia.
Alan H Shih, Cem Meydan, Kaitlyn Shank, Francine E Garrett-Bakelman, Patrick S Ward

Cancer Discov· May 2017

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is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells.
Hiroyoshi Kunimoto, Anna Sophia McKenney, Cem Meydan, Kaitlyn Shank, Abbas Nazir, Alan H Shih

Blood· March 2017

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Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.
Satoshi Inoue, Wanda Y Li, Alan Tseng, Isabel Beerman, Andrew J Elia, Alan H Shih

Cancer Cell· August 2016

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A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.
Dali Han, Xingyu Lu, Alan H Shih, Ji Nie, Qiancheng You

Mol Cell· August 2016

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Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles.
Megan A Hatlen, Kanika Arora, Vladimir Vacic, Ewa A Grabowska, Willey Liao, Alan H Shih

J Exp Med· January 2016

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