Publications by authors named "Alan Wheeldon"

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Fused tricyclic pyrrolizinones that exhibit pseudo-irreversible blockade of the NK1 receptor.
Gregori J Morriello, Gary Chicchi, Tricia Johnson, Sander G Mills, Julie Demartino, Alan Wheeldon

Bioorg Med Chem Lett· October 2010

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Tetrahydroindolizinone NK1 antagonists.
Jianming Bao, Huagang Lu, Gregori J Morriello, Emma J Carlson, Alan Wheeldon

Bioorg Med Chem Lett· April 2010

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Substituted fused bicyclic pyrrolizinones as potent, orally bioavailable hNK1 antagonists.
Gregori J Morriello, Sander G Mills, Tricia Johnson, Mikhail Reibarkh, Gary Chicchi, Alan Wheeldon

Bioorg Med Chem Lett· March 2010

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Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists.
Jinlong Jiang, Jaime L Bunda, Geoge A Doss, Gary G Chicchi, Marc M Kurtz, Alan Wheeldon

J Med Chem· May 2009

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UDP-glucose modulates gastric function through P2Y14 receptor-dependent and -independent mechanisms.
Anna K Bassil, Sophie Bourdu, Karen A Townson, Alan Wheeldon, Emma M Jarvie

Am J Physiol Gastrointest Liver Physiol· April 2009

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Fused bicyclic pyrrolizinones as new scaffolds for human NK1 antagonists.
Gregori J Morriello, Robert J Devita, Sander G Mills, Jonathan R Young, Peter Lin, Alan Wheeldon

Bioorg Med Chem· March 2008

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Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications.
James G Bilsland, Alan Wheeldon, Andrew Mead, Petr Znamenskiy, Sarah Almond

Neuropsychopharmacology· February 2008

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Pyrrolidine-carboxamides and oxadiazoles as potent hNK1 antagonists.
Jonathan R Young, Ronsar Eid, Cherilyn Turner, Robert J DeVita, Marc M Kurtz, Alan Wheeldon

Bioorg Med Chem Lett· October 2007

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The discovery of potent, selective, and orally bioavailable hNK1 antagonists derived from pyrrolidine.
Peter Lin, Lehua Chang, Robert J Devita, Jonathan R Young, Ronsar Eid, Alan Wheeldon

Bioorg Med Chem Lett· September 2007

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Demonstration of functional neuronal beta3-adrenoceptors within the enteric nervous system.
Selim Cellek, Ramkumar Thangiah, Anna K Bassil, Colin A Campbell, Karen M Gray, Alan Wheeldon

Gastroenterology· July 2007

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A rapid method for the quantification of mouse hippocampal neurogenesis in vivo by flow cytometry. Validation with conventional and enhanced immunohistochemical methods.
James George Bilsland, Christine Haldon, Julie Goddard, Kevin Oliver, Fraser Murray, Alan Wheeldon

J Neurosci Methods· October 2006

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NK1 antagonists based on seven membered lactam scaffolds.
Jason M Elliott, Emma J Carlson, Gary G Chicchi, Olivier Dirat, Maria Dominguez, Alan Wheeldon

Bioorg Med Chem Lett· June 2006

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1-Phenyl-8-azabicyclo[3.2.1]octane ethers: a novel series of neurokinin (NK1) antagonists.
Ian T Huscroft, Emma J Carlson, Gary G Chicchi, Marc M Kurtz, Clare London, Alan Wheeldon

Bioorg Med Chem Lett· April 2006

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Synthesis and structure-activity relationships of 8-azabicyclo[3.2.1]octane benzylamine NK1 antagonists.
Christopher G Thomson, Emma Carlson, Gary G Chicchi, Janusz J Kulagowski, Marc M Kurtz, Alan Wheeldon

Bioorg Med Chem Lett· February 2006

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Inhibition of acute nociceptive responses in rat spinal cord by a bradykinin B1 receptor antagonist.
Rachel K Conley, Alan Wheeldon, Janine K Webb, Robert M DiPardo, Carl F Homnick

Eur J Pharmacol· December 2005

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