Publications by authors named "Albert Enz"

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AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: identification, SAR and pharmacological characterization.
Ivo Vranesic, Silvio Ofner, Peter Josef Flor, Graeme Bilbe, Rochdi Bouhelal, Albert Enz

Bioorg Med Chem· November 2014

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Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst(3) receptor antagonists.
Thomas Troxler, Konstanze Hurth, Karl-Heinrich Schuh, Philippe Schoeffter, Daniel Langenegger, Albert Enz

Bioorg Med Chem Lett· March 2010

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Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application.
Andreas Lerchner, Rainer Machauer, Claudia Betschart, Siem Veenstra, Heinrich Rueeger, Albert Enz

Bioorg Med Chem Lett· January 2010

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Similar rivastigmine pharmacokinetics and pharmacodynamics in Japanese and white healthy participants following the application of novel rivastigmine patch.
Gilbert Lefèvre, Monika Büche, Greg Sedek, Steve Maton, Albert Enz

J Clin Pharmacol· April 2009

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Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists.
Albert Enz, Dominik Feuerbach, Mathias U Frederiksen, Conrad Gentsch, Konstanze Hurth

Bioorg Med Chem Lett· March 2009

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Discovery of novel non-peptidic beta-alanine piperazine amide derivatives and their optimization to achiral, easily accessible, potent and selective somatostatin sst1 receptor antagonists.
Thomas Troxler, Konstanze Hurth, Henri Mattes, Mahavir Prashad, Philippe Schoeffter, Albert Enz

Bioorg Med Chem Lett· March 2009

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The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain.
Dominik Feuerbach, Kurt Lingenhoehl, Hans-Rudolf Olpe, Annick Vassout, Conrad Gentsch, Albert Enz

Neuropharmacology· January 2009

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Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst 1 receptor.
Thomas Troxler, Albert Enz, Daniel Hoyer, Daniel Langenegger, Peter Neumann

Bioorg Med Chem Lett· February 2008

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N1phenethyl-norcymserine, a selective butyrylcholinesterase inhibitor, increases acetylcholine release in rat cerebral cortex: a comparison with donepezil and rivastigmine.
Francesca Cerbai, Maria Grazia Giovannini, Claudia Melani, Albert Enz, Giancarlo Pepeu

Eur J Pharmacol· October 2007

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SAR of the arylpiperazine moiety of obeline somatostatin sst1 receptor antagonists.
Konstanze Hurth, Albert Enz, Philipp Floersheim, Conrad Gentsch, Daniel Hoyer

Bioorg Med Chem Lett· July 2007

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Targeting acetylcholinesterase and butyrylcholinesterase in dementia.
Roger M Lane, Steven G Potkin, Albert Enz

Int J Neuropsychopharmacol· February 2006

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Cholinesterases: roles in the brain during health and disease.
Clive G Ballard, Nigel H Greig, Angela L Guillozet-Bongaarts, Albert Enz, Sultan Darvesh

Curr Alzheimer Res· July 2005

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Rivastigmine as a modulator of the neuronal glutamate transporter rEAAC1 mRNA expression.
Josefine Andin, Albert Enz, Conrad Gentsch, Jan Marcusson

Dement Geriatr Cogn Disord· May 2005

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In vivo detection of amyloid-beta deposits by near-infrared imaging using an oxazine-derivative probe.
Martin Hintersteiner, Albert Enz, Peter Frey, Anne-Lise Jaton, Willy Kinzy

Nat Biotechnol· May 2005

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Co-administration of memantine has no effect on the in vitro or ex vivo determined acetylcholinesterase inhibition of rivastigmine in the rat brain.
Albert Enz, Conrad Gentsch

Neuropharmacology· September 2004

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A locally active antiinflammatory macrolide (MLD987) for inhalation therapy of asthma.
Rene Hersperger, Karl-Heinz Buchheit, Salvatore Cammisuli, Albert Enz, Olivier Lohse

J Med Chem· September 2004

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A simple, rapid and sensitive method for simultaneous determination of rivastigmine and its major metabolite NAP 226-90 in rat brain and plasma by reversed-phase liquid chromatography coupled to electrospray ionization mass spectrometry.
Albert Enz, Alain Chappuis, Andre Dattler

Biomed Chromatogr· April 2004

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Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis.
Sonia Boncristiano, Michael E Calhoun, Peter H Kelly, Michelle Pfeifer, Luca Bondolfi, Albert Enz

J Neurosci· April 2002

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Brain pharmacokinetics of a nonpeptidic corticotropin-releasing factor receptor antagonist.
Caroline Keller, Armin Bruelisauer, Michel Lemaire, Albert Enz

Drug Metab Dispos· February 2002

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