Publications by authors named "Albert T Profy"

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Effects of the Soluble Guanylate Cyclase Stimulator Praliciguat in Diabetic Kidney Disease: A Randomized Placebo-Controlled Clinical Trial.
John P Hanrahan, Ian H de Boer, George L Bakris, Phebe J Wilson, James D Wakefield, Albert T Profy

Clin J Am Soc Nephrol· December 2020

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Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells.
Guang Liu, Courtney M Shea, Juli E Jones, Gavrielle M Price, William Warren, Albert T Profy

Am J Physiol Renal Physiol· October 2020

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Effect of Praliciguat on Peak Rate of Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction: The CAPACITY HFpEF Randomized Clinical Trial.
James E Udelson, Gregory D Lewis, Sanjiv J Shah, Michael R Zile, Margaret M Redfield, Albert T Profy

JAMA· October 2020

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An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension.
John P Hanrahan, Jelena P Seferovic, James D Wakefield, Phebe J Wilson, Jennifer G Chickering, Albert T Profy

Diabetologia· April 2020

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Rationale and design for a multicenter, randomized, double-blind, placebo-controlled, phase 2 study evaluating the safety and efficacy of the soluble guanylate cyclase stimulator praliciguat over 12 weeks in patients with heart failure with preserved ejection fraction (CAPACITY HFpEF).
James E Udelson, Gregory D Lewis, Sanjiv J Shah, Michael R Zile, Margaret M Redfield, Albert T Profy

Am Heart J· April 2020

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Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical-stage soluble guanylate cyclase stimulator in rats.
Ali R Banijamali, Andrew E Carvalho, James D Wakefield, Peter Germano, Timothy C Barden, Albert T Profy

Pharmacol Res Perspect· April 2020

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A Randomized, Placebo-Controlled, Multiple-Ascending-Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Soluble Guanylate Cyclase Stimulator Praliciguat in Healthy Subjects.
John P Hanrahan, James D Wakefield, Phebe J Wilson, Marina Mihova, Jennifer G Chickering, Albert T Profy

Clin Pharmacol Drug Dev· July 2019

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Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease.
Jenny V Tobin, Daniel P Zimmer, Courtney Shea, Peter Germano, Sylvie G Bernier, Albert T Profy

J Pharmacol Exp Ther· June 2018

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Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017.
G. Todd Milne, , Peter Sandner, Kathleen A. Lincoln, Paul C. Harrison, Albert T. Profy

BMC Pharmacol Toxicol· October 2017

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Postcoital bioavailability and antiviral activity of 0.5% PRO 2000 gel: implications for future microbicide clinical trials.
Marla J Keller, Pedro M M Mesquita, N Merna Torres, Sylvia Cho, Gail Shust, Albert T Profy

PLoS One· January 2010

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The candidate sulfonated microbicide, PRO 2000, has potential multiple mechanisms of action against HIV-1.
Dana Huskens, Kurt Vermeire, Albert T Profy, Dominique Schols

Antiviral Res· October 2009

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The differential binding and activity of PRO 2000 against diverse HIV-1 envelopes.
Darpun D Sachdev, Bouchra Zerhouni-Layachi, Mila Ortigoza, Albert T Profy, Michael Tuen

J Acquir Immune Defic Syndr· June 2009

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PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity.
Marla J Keller, Esmeralda Guzman, Ehsan Hazrati, Andrea Kasowitz, Natalia Cheshenko, Albert T Profy

AIDS· February 2007

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ACIDFORM inactivates herpes simplex virus and prevents genital herpes in a mouse model: optimal candidate for microbicide combinations.
Ana C G Tuyama, Natalia Cheshenko, Maria J Carlucci, Jin-Hua Li, Cindy L Goldberg, Albert T Profy

J Infect Dis· September 2006

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Direct measurement of in-vivo vaginal microbicide levels of PRO 2000 achieved in a human safety study.
Charles J N Lacey, Anne Wright, Jonathan N Weber, Albert T Profy

AIDS· April 2006

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PRO 2000 gel inhibits HIV and herpes simplex virus infection following vaginal application: a double-blind placebo-controlled trial.
Marla J Keller, Bouchra Zerhouni-Layachi, Natalia Cheshenko, Minnie John, Kathleen Hogarty, Albert T Profy

J Infect Dis· January 2006

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Candidate sulfonated and sulfated topical microbicides: comparison of anti-human immunodeficiency virus activities and mechanisms of action.
Irini A Scordi-Bello, Arevik Mosoian, Cejiang He, Yiban Chen, Yang Cheng, Albert T Profy

Antimicrob Agents Chemother· September 2005

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Candidate topical microbicides bind herpes simplex virus glycoprotein B and prevent viral entry and cell-to-cell spread.
Natalia Cheshenko, Marla J Keller, Veronica MasCasullo, Gary A Jarvis, Hui Cheng, Albert T Profy

Antimicrob Agents Chemother· June 2004

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Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop.
Robyn L Stanfield, Jayant B Ghiara, Erica Ollmann Saphire, Albert T Profy, Ian A Wilson

Virology· October 2003

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The acceptability of an investigational vaginal microbicide, PRO 2000 Gel, among women in a phase I clinical trial.
Kathleen Morrow, Rochelle Rosen, Linda Richter, Anne Emans, Anna Forbes, Albert T Profy

J Womens Health (Larchmt)· September 2003

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Safety and acceptability of penile application of 2 candidate topical microbicides: BufferGel and PRO 2000 Gel: 3 randomized trials in healthy low-risk men and HIV-positive men.
Stephen R Tabet, Marianne M Callahan, Christine K Mauck, Fang Gai, Anne S Coletti, Albert T Profy

J Acquir Immune Defic Syndr· August 2003

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Safety and tolerability of vaginal PRO 2000 gel in sexually active HIV-uninfected and abstinent HIV-infected women.
Kenneth H Mayer, Salim Abdool Karim, Clifton Kelly, Lisa Maslankowski, Helen Rees, Albert T Profy

AIDS· February 2003

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