Publications by authors named "Alberto Podjarny"

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Lipid exchange in crystal-confined fatty acid binding proteins: X-ray evidence and molecular dynamics explanation.
H Ariel Alvarez, Alexandra Cousido-Siah, Yanis R Espinosa, Alberto Podjarny, C Manuel Carlevaro

Proteins· November 2023

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High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon Expression.
Juline Poirson, Irina Paula Suarez, Marie-Laure Straub, Alexandra Cousido-Siah, Paul Peixoto, Alberto Podjarny

J Virol· May 2022

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Discovery of -Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II.
Michael C Van Zandt, G Erik Jagdmann, Darren L Whitehouse, Minkoo Ji, Jennifer Savoy, Alberto D Podjarny

J Med Chem· September 2019

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Structural Basis of Outstanding Multivalent Effects in Jack Bean α-Mannosidase Inhibition.
Eduardo Howard, Alexandra Cousido-Siah, Mathieu L Lepage, Jérémy P Schneider, Anne Bodlenner, Alberto Podjarny

Angew Chem Int Ed Engl· July 2018

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Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase.
Isidro Crespo, Joan Giménez-Dejoz, Sergio Porté, Alexandra Cousido-Siah, André Mitschler, Alberto Podjarny

Eur J Med Chem· May 2018

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Neutron macromolecular crystallography.
Matthew P Blakeley, Alberto D Podjarny

Emerg Top Life Sci· April 2018

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Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma.
Marzena Mazur, Jacek Olczak, Sylwia Olejniczak, Robert Koralewski, Wojciech Czestkowski, Alberto Podjarny

J Med Chem· February 2018

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Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008.
Francesc X Ruiz, Isidro Crespo, Susana Álvarez, Sergio Porté, Joan Giménez-Dejoz, Alberto Podjarny

Chem Biol Interact· October 2017

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X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain.
Firas Fadel, Yuguang Zhao, Alexandra Cousido-Siah, Francesc X Ruiz, André Mitschler, Alberto Podjarny

PLoS One· March 2017

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Structural variability of E. coli thioredoxin captured in the crystal structures of single-point mutants.
Martín E Noguera, Diego S Vazquez, Gerardo Ferrer-Sueta, William A Agudelo, Eduardo Howard, Alberto Podjarny

Sci Rep· February 2017

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IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors.
Alexandra Cousido-Siah, Francesc X Ruiz, Jindřich Fanfrlík, Joan Giménez-Dejoz, André Mitschler, Alberto D Podjarny

ACS Chem Biol· October 2016

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The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase.
Wanda M Valsecchi, Alexandra Cousido-Siah, Lucas A Defelipe, André Mitschler, Alberto Podjarny

Biochim Biophys Acta· June 2016

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Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase.
Joan Giménez-Dejoz, Michal H Kolář, Francesc X Ruiz, Isidro Crespo, Alexandra Cousido-Siah, Alberto Podjarny

PLoS One· May 2016

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Iminosugar-Cyclopeptoid Conjugates Raise Multivalent Effect in Glycosidase Inhibition at Unprecedented High Levels.
Mathieu L Lepage, Jérémy P Schneider, Anne Bodlenner, Alessandra Meli, Francesco De Riccardis, Alberto Podjarny

Chemistry· April 2016

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Probing the roles of two tryptophans surrounding the unique zinc coordination site in lipase family I.5.
Emel Timucin, Alexandra Cousido-Siah, André Mitschler, Alberto Podjarny, Osman Ugur Sezerman

Proteins· January 2016

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Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.
Denise Martinez-Zapien, Francesc Xavier Ruiz, Juline Poirson, André Mitschler, Juan Ramirez, Alberto Podjarny

Nature· January 2016

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Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10.
Francesc X Ruiz, Alexandra Cousido-Siah, Sergio Porté, Marta Domínguez, Isidro Crespo, Alberto Podjarny

ChemMedChem· December 2015

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The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition.
Jindřich Fanfrlík, Francesc X Ruiz, Aneta Kadlčíková, Jan Řezáč, Alexandra Cousido-Siah, Alberto D Podjarny

ACS Chem Biol· July 2015

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New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM.
Firas Fadel, Yuguang Zhao, Raul Cachau, Alexandra Cousido-Siah, Francesc X Ruiz, Alberto Podjarny

Acta Crystallogr D Biol Crystallogr· July 2015

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Structural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10.
Alexandra Cousido-Siah, Francesc X Ruiz, Isidro Crespo, Sergio Porté, André Mitschler, Alberto Podjarny

Chem Biol Interact· June 2015

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Structural characterization of metal binding to a cold-adapted frataxin.
Martín E Noguera, Ernesto A Roman, Juan B Rigal, Alexandra Cousido-Siah, André Mitschler, Alberto Podjarny

J Biol Inorg Chem· June 2015

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Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design.
Alexandra Cousido-Siah, Francesc X Ruiz, André Mitschler, Sergio Porté, Ángel R de Lera, Alberto Podjarny

Acta Crystallogr D Biol Crystallogr· March 2014

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Modulation of aldose reductase inhibition by halogen bond tuning.
Jindřich Fanfrlík, Michal Kolář, Martin Kamlar, David Hurný, Francesc X Ruiz, Alberto Podjarny

ACS Chem Biol· November 2013

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Linear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10.
Fabrice A C Klein, Gabrielle Zeder-Lutz, Alexandra Cousido-Siah, André Mitschler, Aline Katz, Alberto Podjarny

Hum Mol Genet· October 2013

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Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction.
Adam Golebiowski, Darren Whitehouse, R Paul Beckett, Michael Van Zandt, Min Koo Ji, Alberto Podjarny

Bioorg Med Chem Lett· September 2013

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