Publications by authors named "Alec D Lebsack"

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Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
Mark S Tichenor, John J M Wiener, Navin L Rao, Genesis M Bacani, Jianmei Wei, Alec D Lebsack

J Med Chem· November 2022

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Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity.
Mark S Tichenor, John J M Wiener, Navin L Rao, Charlotte Pooley Deckhut, J Kent Barbay, Alec D Lebsack

ACS Med Chem Lett· May 2021

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Accelerating Lead Identification by High Throughput Virtual Screening: Prospective Case Studies from the Pharmaceutical Industry.
Kelly L Damm-Ganamet, Nidhi Arora, Stephane Becart, James P Edwards, Alec D Lebsack

J Chem Inf Model· May 2019

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Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.
Jonathan M Blevitt, Michael D Hack, Krystal L Herman, Paul F Jackson, Paul J Krawczuk, Alec D Lebsack

J Med Chem· April 2017

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The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists.
Jason C Rech, Anindya Bhattacharya, Bryan J Branstetter, Christopher J Love, Joseph E Leenaerts, Alec D Lebsack

Bioorg Med Chem Lett· October 2016

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A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors.
Jonathan M Blevitt, Michael D Hack, Krystal Herman, Leon Chang, John M Keith, Alec D Lebsack

J Biol Chem· June 2016

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Polypharmacology of Small-Molecule Modulators of the 5-Lipoxygenase Activating Protein (FLAP) Observed via a High-throughput Lipidomics Platform.
Jiao Song, Xuejun Liu, Jian Zhu, Mandana Tootoonchi, John M Keith, Alec D Lebsack

J Biomol Screen· February 2016

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Stereocontrolled enantioselective total synthesis of the [2+2] quadrigemine alkaloids.
Stephen M Canham, Benjamin D Hafensteiner, Alec D Lebsack, Tricia L May-Dracka, Sangkil Nam

Tetrahedron· September 2015

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Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist.
Michael P Maher, Anindya Bhattacharya, Hong Ao, Nadia Swanson, Nyan-Tsz Wu, Alec D Lebsack

Eur J Pharmacol· August 2011

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1,2-diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties.
Alec D Lebsack, Jason C Rech, Bryan J Branstetter, Natalie A Hawryluk, Jeffrey E Merit

Bioorg Med Chem Lett· December 2010

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Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists.
Natalie A Hawryluk, Jeffrey E Merit, Alec D Lebsack, Bryan J Branstetter, Michael D Hack

Bioorg Med Chem Lett· December 2010

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Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist.
Shankar Venkatraman, Alec D Lebsack, Kenneth Alves, Michael F Gardner, Joyce James

Bioorg Med Chem Lett· October 2009

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Identification and synthesis of 2,7-diamino-thiazolo[5,4-d]pyrimidine derivatives as TRPV1 antagonists.
Alec D Lebsack, Bryan J Branstetter, Michael D Hack, Wei Xiao, Matthew L Peterson

Bioorg Med Chem Lett· January 2009

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Identification and synthesis of [1,2,4]triazolo[3,4-a]phthalazine derivatives as high-affinity ligands to the alpha 2 delta-1 subunit of voltage gated calcium channel.
Alec D Lebsack, Janet Gunzner, Bowei Wang, Richard Pracitto, Hervé Schaffhauser

Bioorg Med Chem Lett· May 2004

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Enantioselective total synthesis of quadrigemine C and psycholeine.
Alec D Lebsack, J T Link, Larry E Overman, Brian A Stearns

J Am Chem Soc· August 2002

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