Publications by authors named "Brian A Stearns"

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Targeting quinolone- and aminocoumarin-resistant bacteria with new gyramide analogs that inhibit DNA gyrase.
Katherine A Hurley, Thiago M A Santos, Molly R Fensterwald, Madhusudan Rajendran, Jared T Moore, Brian A Stearns

Medchemcomm· February 2017

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Stereocontrolled enantioselective total synthesis of the [2+2] quadrigemine alkaloids.
Stephen M Canham, Benjamin D Hafensteiner, Alec D Lebsack, Tricia L May-Dracka, Sangkil Nam, Brian A Stearns

Tetrahedron· September 2015

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DP2 (CRTh2) antagonism reduces ocular inflammation induced by allergen challenge and respiratory syncytial virus.
Karin J Stebbins, Alexander R Broadhead, Alla Musiyenko, Sailen Barik, Jill M Scott, Brian A Stearns

Int Arch Allergy Immunol· May 2012

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Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis.
Jill M Scott, Christopher Baccei, Gretchen Bain, Alex Broadhead, Jilly F Evans, Brian A Stearns

Bioorg Med Chem Lett· November 2011

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Therapeutic efficacy of AM156, a novel prostanoid DP2 receptor antagonist, in murine models of allergic rhinitis and house dust mite-induced pulmonary inflammation.
Karin J Stebbins, Alex R Broadhead, Lucia D Correa, Jill M Scott, Yen P Truong, Brian A Stearns

Eur J Pharmacol· July 2010

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Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung.
Karin J Stebbins, Alex R Broadhead, Christopher S Baccei, Jill M Scott, Yen P Truong, Brian A Stearns

J Pharmacol Exp Ther· March 2010

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Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis.
Brian A Stearns, Christopher Baccei, Gretchen Bain, Alex Broadhead, Ryan C Clark

Bioorg Med Chem Lett· August 2009

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Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives as high-affinity ligands of the alpha(2)delta subunit of voltage-gated calcium channels.
Tao Hu, Brian A Stearns, Brian T Campbell, Jeannie M Arruda, Chixu Chen

Bioorg Med Chem Lett· May 2004

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Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives: high-affinity ligands to the alpha 2 delta subunit of voltage gated calcium channels.
Brian A Stearns, Naomi Anker, Jeannie M Arruda, Brian T Campbell, Chixu Chen

Bioorg Med Chem Lett· March 2004

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Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type III (AKR1C2).
John W Trauger, Alice Jiang, Brian A Stearns, Philip V LoGrasso

Biochemistry· November 2002

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Enantioselective total synthesis of quadrigemine C and psycholeine.
Alec D Lebsack, J T Link, Larry E Overman, Brian A Stearns

J Am Chem Soc· August 2002

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