Publications by authors named "Alejandro Pezzulo"

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Theratyping as a tool to guide clinical decision-making in patients with suspected cystic fibrosis and variants currently ineligible for CFTR modulator therapy.
Ryan M Gannon, Brittany A Wright, Brandon A Bettis, Mary E Teresi, Anthony J Fischer, Alejandro A Pezzulo

Respir Med· December 2025

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Porcine airway tissue explant culture at a hydrogel-air interface to model submucosal glands in cystic fibrosis progression and therapy.
Kaleb C Bierstedt, Meng-Hsuan Lin, Wenjie Yu, Ashley L Cooney, Brian J Goodell, Alejandro A Pezzulo

Sci Adv· November 2025

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IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo via eicosanoid signalling.
Shreya Ghimire, Biyun Xue, Kun Li, Ryan M Gannon, Christine L Wohlford-Lenane, Alejandro A Pezzulo

EBioMedicine· October 2025

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Residential fungal β-(1,3)-D-glucan exposure is associated with decreased pulmonary function in fibrotic pulmonary sarcoidosis.
Emma M Stapleton, Nervana Metwali, Michael Shlossman, Linder Wendt, Alejandro A Pezzulo

Sarcoidosis Vasc Diffuse Lung Dis· September 2025

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The extracellular matrix protein periostin is required for wound repair in primary human airway epithelia.
Lorena A Tran, Michael Catlin, Scott Schecter, Andrew L Thurman, Shreya Ghimire, Alejandro A Pezzulo

Am J Physiol Lung Cell Mol Physiol· June 2025

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Developmental epigenetic programming by Tet1/3 determines peripheral CD8 T cell fate.
Kara M Misel-Wuchter, Andrew L Thurman, Jordan T Johnson, Athmane Teghanemt, Neelam Gautam, Alejandro A Pezzulo

EMBO Rep· May 2025

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Complement is primarily activated in the lung in a mouse model of severe COVID-19.
Peter J Szachowicz, Christine Wohlford-Lenane, Cobey J Donelson, Shreya Ghimire, Andrew Thurman, Alejandro A Pezzulo

iScience· March 2025

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Manual segmentation of opacities and consolidations on CT of long COVID patients from multiple annotators.
Diedre S Carmo, Alejandro A Pezzulo, Raul A Villacreses, McKenna L Eisenbeisz, Rachel L Anderson

Sci Data· March 2025

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Residential fungal β-(1,3)-D-glucan exposure is associated with decreased pulmonary function in fibrotic pulmonary sarcoidosis.
Emma M Stapleton, Nervana Metwali, Michael Shlossman, Linder Wendt, Alejandro A Pezzulo

Res Sq· October 2024

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IL-13 induces loss of CFTR in ionocytes and reduces airway epithelial fluid absorption.
Guillermo S Romano Ibarra, Lei Lei, Wenjie Yu, Andrew L Thurman, Nicholas D Gansemer, Alejandro A Pezzulo

J Clin Invest· September 2024

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Development and Initial Characterization of Pigs with Mutations and Primary Ciliary Dyskinesia.
Mahmoud A Abou Alaiwa, Brie M Hilkin, Margaret P Price, Nicholas D Gansemer, Michael R Rector, Alejandro A Pezzulo

bioRxiv· August 2024

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Eosinophil expression of triggering receptor expressed on myeloid cells 1 (TREM-1) restricts type 2 lung inflammation.
Jayden L Bowen, Kathy Keck, Sankar Baruah, Kathy H Nguyen, Andrew L Thurman, Alejandro A Pezzulo

J Leukoc Biol· July 2024

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IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo.
Shreya Ghimire, Biyun Xue, Kun Li, Ryan M Gannon, Christine L Wohlford-Lenane, Alejandro A Pezzulo

bioRxiv· July 2024

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Epithelial responses to CFTR modulators are improved by inflammatory cytokines and impaired by antiinflammatory drugs.
Tayyab Rehman, Alejandro A Pezzulo, Andrew L Thurman, Rachel L Zemans, Michael J Welsh

JCI Insight· June 2024

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A predominately pulmonary activation of complement in a mouse model of severe COVID-19.
Peter J Szachowicz, Christine Wohlford-Lenane, Cobey J Heinen, Shreya Ghimire, Biyun Xue, Alejandro A Pezzulo

bioRxiv· June 2024

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Interleukin 13-Induced Inflammation Increases DPP4 Abundance but Does Not Enhance Middle East Respiratory Syndrome Coronavirus Replication in Airway Epithelia.
Kun Li, Jennifer A Bartlett, Christine L Wohlford-Lenane, Biyun Xue, Andrew L Thurman, Alejandro A Pezzulo

J Infect Dis· May 2024

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Long-COVID improves in 50% of patients after a year in a Midwestern cohort.
Grant Stalker, Rosarie Tudas, Alpana Garg, Lauren Graham, Andrew L Thurman, Alejandro Pezzulo

medRxiv· May 2024

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Increased ENaC-mediated liquid absorption across vitamin-D deficient human airway epithelia.
Emma M Stapleton, Andrew L Thurman, Alejandro A Pezzulo, Alejandro P Comellas, Ian M Thornell

Am J Physiol Cell Physiol· February 2024

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Adaptation of SARS-CoV-2 to ACE2 mice reveals new spike residues that drive mouse infection.
Kun Li, Abhishek Verma, Pengfei Li, Miguel E Ortiz, Grant M Hawkins, Alejandro A Pezzulo

J Virol· January 2024

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DNA demethylation fine-tunes IL-2 production during thymic regulatory T cell differentiation.
Athmane Teghanemt, Kara Misel-Wuchter, Jace Heath, Andrew Thurman, Priyanjali Pulipati, Alejandro Pezzulo

EMBO Rep· May 2023

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WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia.
Tayyab Rehman, Philip H Karp, Andrew L Thurman, Steven E Mather, Akansha Jain, Alejandro A Pezzulo

Am J Respir Cell Mol Biol· October 2022

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FXYD3 facilitates Na and liquid absorption across human airway epithelia by increasing the transport capacity of the Na/K ATPase.
Camilo Cano Portillo, Raul Villacreses, Andrew L Thurman, Alejandro A Pezzulo, Joseph Zabner

Am J Physiol Cell Physiol· October 2022

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Quantitative Chest CT Assessment of Small Airways Disease in Post-Acute SARS-CoV-2 Infection.
Josalyn L Cho, Raul Villacreses, Prashant Nagpal, Junfeng Guo, Alejandro A Pezzulo

Radiology· July 2022

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Vitamin D-mediated effects on airway innate immunity in vitro.
Emma M Stapleton, Kathy Keck, Robert Windisch, Mallory R Stroik, Andrew L Thurman, Alejandro A Pezzulo

PLoS One· June 2022

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Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19.
Lok-Yin Roy Wong, Jian Zheng, Kevin Wilhelmsen, Kun Li, Miguel E Ortiz, Alejandro A Pezzulo

Nature· May 2022

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