Publications by authors named "Alex Conner"

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The Concise Guide to PHARMACOLOGY 2023/24: Ion channels.
Stephen P H Alexander, Alistair A Mathie, John A Peters, Emma L Veale, Jörg Striessnig, Alex C Conner

Br J Pharmacol· October 2023

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Molecular mechanisms governing aquaporin relocalisation.
Andrea Markou, Lucas Unger, Mohammed Abir-Awan, Ahmed Saadallah, Andrea Halsey, Matthew Conner, Alex Conner

Biochim Biophys Acta Biomembr· April 2022

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Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis.
Mootaz M Salman, Philip Kitchen, Andrea Halsey, Marie Xun Wang, Susanna Törnroth-Horsefield, Alex C Conner

Brain· March 2022

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Simultaneous binding of the N- and C-terminal cytoplasmic domains of aquaporin 4 to calmodulin.
Hiroaki Ishida, Hans J Vogel, Alex C Conner, Philip Kitchen, Roslyn M Bill

Biochim Biophys Acta Biomembr· February 2022

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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels.
Stephen Ph Alexander, Alistair Mathie, John A Peters, Emma L Veale, Jörg Striessnig, Alex C Conner

Br J Pharmacol· October 2021

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Calcein Fluorescence Quenching to Measure Plasma Membrane Water Flux in Live Mammalian Cells.
Philip Kitchen, Mootaz M Salman, Mohammed Abir-Awan, Tamim Al-Jubair, Susanna Törnroth-Horsefield, Alex C Conner

STAR Protoc· December 2020

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Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema.
Philip Kitchen, Mootaz M Salman, Andrea M Halsey, Charlotte Clarke-Bland, Justin A MacDonald, Matthew T Conner, Alex C Conner

Cell· May 2020

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Water channel pore size determines exclusion properties but not solute selectivity.
Philip Kitchen, Mootaz M Salman, Simone U Pickel, Jordan Jennings, Susanna Törnroth-Horsefield, Matthew T Conner, Alex C Conner

Sci Rep· December 2019

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Inhibitors of Mammalian Aquaporin Water Channels.
Mohammed Abir-Awan, Philip Kitchen, Mootaz M Salman, Matthew T Conner, Alex C Conner

Int J Mol Sci· March 2019

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Aquaporins and Their Regulation after Spinal Cord Injury.
Andrea M Halsey, Alex C Conner, Roslyn M Bill, Ann Logan, Zubair Ahmed

Cells· October 2018

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Downregulation of aquaporin 3 inhibits cellular proliferation, migration and invasion in the MDA-MB-231 breast cancer cell line.
Muhammad Arif, Philip Kitchen, Matthew T Conner, Eric J Hill, David Nagel, Alex C Conner

Oncol Lett· July 2018

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Transcriptome Analysis of Gene Expression Provides New Insights into the Effect of Mild Therapeutic Hypothermia on Primary Human Cortical Astrocytes Cultured under Hypoxia.
Mootaz M Salman, Philip Kitchen, M Nicola Woodroofe, Roslyn M Bill, Alex C Conner, Matthew T Conner

Front Cell Neurosci· December 2017

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Hypothermia increases aquaporin 4 (AQP4) plasma membrane abundance in human primary cortical astrocytes via a calcium/transient receptor potential vanilloid 4 (TRPV4)- and calmodulin-mediated mechanism.
Mootaz M Salman, Philip Kitchen, M Nicola Woodroofe, James E Brown, Roslyn M Bill, Alex C Conner, Matthew T Conner

Eur J Neurosci· November 2017

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Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach.
Michael J Woolley, John Simms, Juan Carlos Mobarec, Christopher A Reynolds, David R Poyner, Alex C Conner

Mol Cell Endocrinol· October 2017

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Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs.
Michael J Woolley, Christopher A Reynolds, John Simms, Christopher S Walker, Juan Carlos Mobarec, Alex C Conner

Biochem Pharmacol· October 2017

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Transcriptome analysis suggests a role for the differential expression of cerebral aquaporins and the MAPK signalling pathway in human temporal lobe epilepsy.
Mootaz M Salman, Mariam A Sheilabi, Dev Bhattacharyya, Philip Kitchen, Alex C Conner, Matthew T Conner

Eur J Neurosci· September 2017

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Relative Antagonism of Mutants of the CGRP Receptor Extracellular Loop 2 Domain (ECL2) Using a Truncated Competitive Antagonist (CGRP): Evidence for the Dual Involvement of ECL2 in the Two-Domain Binding Model.
Michael J Woolley, John Simms, Sifat Uddin, David R Poyner, Alex C Conner

Biochemistry· August 2017

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Understanding the common themes and diverse roles of the second extracellular loop (ECL2) of the GPCR super-family.
Michael J Woolley, Alex C Conner

Mol Cell Endocrinol· July 2017

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Plasma Membrane Abundance of Human Aquaporin 5 Is Dynamically Regulated by Multiple Pathways.
Philip Kitchen, Fredrik Öberg, Jennie Sjöhamn, Kristina Hedfalk, Roslyn M Bill, Alex C Conner, Matthew T Conner

PLoS One· June 2016

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Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties.
Harriet A Watkins, Madhuri Chakravarthy, Rekhati S Abhayawardana, Joseph J Gingell, Michael Garelja, Alex C Conner

J Biol Chem· May 2016

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Structural Determinants of Oligomerization of the Aquaporin-4 Channel.
Philip Kitchen, Matthew T Conner, Roslyn M Bill, Alex C Conner

J Biol Chem· March 2016

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Beyond water homeostasis: Diverse functional roles of mammalian aquaporins.
Philip Kitchen, Rebecca E Day, Mootaz M Salman, Matthew T Conner, Roslyn M Bill, Alex C Conner

Biochim Biophys Acta· December 2015

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Control of the Aquaporin-4 Channel Water Permeability by Structural Dynamics of Aromatic/Arginine Selectivity Filter Residues.
Philip Kitchen, Alex C Conner

Biochemistry· November 2015

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Identification and Molecular Mechanisms of the Rapid Tonicity-induced Relocalization of the Aquaporin 4 Channel.
Philip Kitchen, Rebecca E Day, Luke H J Taylor, Mootaz M Salman, Roslyn M Bill, Matthew T Conner, Alex C Conner

J Biol Chem· July 2015

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Structure-activity relationships of the N-terminus of calcitonin gene-related peptide: key roles of alanine-5 and threonine-6 in receptor activation.
Debbie L Hay, Paul W R Harris, Renata Kowalczyk, Margaret A Brimble, Dan L Rathbone, Alex C Conner

Br J Pharmacol· January 2014

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