Publications by authors named "Alex Hewitt"

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Association of Polygenic Scores for Glaucoma With Measures of Retinal Ganglion Cell Integrity in Young and Older Adults.
Samantha Sze-Yee Lee, Santiago Diaz Torres, Gareth Lingham, Seyhan Yazar, Michael Hunter, Alex W Hewitt

Am J Ophthalmol· January 2026

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A generalised vision transformer-based self-supervised model for diagnosing and grading prostate cancer using histological images.
Abadh K Chaurasia, Helen C Harris, Patrick W Toohey, Alex W Hewitt

Prostate Cancer Prostatic Dis· December 2025

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Genomic structural equation Modeling analysis of glaucoma Endophenotypes: investigating genetic architecture and non-intraocular pressure mechanisms.
Maryam Marzban, Santiago Diaz-Torres, Jackson Thorp, Jue Sheng Ong, Anthony P Khawaja, Alex W Hewitt

Hum Mol Genet· November 2025

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Generalizable features of pegRNA design for prime editing of inherited retinal diseases.
Freya M Patterson, Minh Thuan Nguyen Tran, Thomas Guinan, Mohd Khairul Nizam Mohd Khalid, Rajendra Kc, Alex W Hewitt

Ophthalmic Genet· November 2025

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Automated quantification of Ki-67 expression in breast cancer from H&E-stained slides using a transformer-based regression model.
Abadh K Chaurasia, Patrick W Toohey, Matthew T Bennett, Helen C Harris, Alex W Hewitt

Breast Cancer Res· November 2025

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Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy.
Christopher R Bye, Elizabeth Qian, Katherine Lim, Maciej Daniszewski, Fleur C Garton, Alex W Hewitt

Nat Neurosci· November 2025

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Generation of Donor-Specific iPSC for Modelling Lysosomal Storage Disorders.
Sueanne Chear, Adelene Chiam, Jana Talbot, Bryony N Thorne, Emma J Wilkinson, Alex W Hewitt

Methods Mol Biol· October 2025

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A Multitrait Polygenic Risk Score for Open-Angle Glaucoma Stratifies Risk of Pigmentary Glaucoma in Pigment Dispersion Syndrome.
Antonia Kolovos, Ayub Qassim, Henry N Marshall, Thi Thi Nguyen, Joshua Schmidt, Alex W Hewitt

Ophthalmol Glaucoma· October 2025

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Multi-resolution vision transformer model for histopathological skin cancer subtype classification using whole slide images.
Abadh K Chaurasia, Patrick W Toohey, Helen C Harris, Alex W Hewitt

Comput Biol Med· September 2025

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Polygenic prediction of body mass index and obesity through the life course and across ancestries.
Roelof A J Smit, Kaitlin H Wade, Qin Hui, Joshua D Arias, Xianyong Yin, Alex W Hewitt

Nat Med· September 2025

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A Multitrait Open-Angle Glaucoma Polygenic Risk Score Stratifies Risk of Glaucoma Diagnosis and Severity in Eyes with Pseudoexfoliation.
Antonia Kolovos, Ayub Qassim, Mark M Hassall, Henry N Marshall, Joshua Schmidt, Alex W Hewitt

Ophthalmology· August 2025

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Evaluating Practical Approaches for Including MYOC Variants Alongside Common Variants for Genetics-Based Risk Stratification for Glaucoma.
Ngoc-Quynh Le, Weixiong He, Matthew H Law, Sarah E Medland, David A Mackey, Alex W Hewitt

Am J Ophthalmol· June 2025

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Functional genomics in age-related macular degeneration: From genetic associations to understanding disease mechanisms.
Rinki Ratnapriya, Felix Grassman, Rui Chen, Alex Hewitt, Jianhai Du

Exp Eye Res· May 2025

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Cytometric Evaluation of Cytokine Factors in Serum and Vitreous from Endophthalmitis Patients: Correlated Elevation in Neutrophil Markers.
Christina Carroll, Danica Joseph, Penelope J Allen, Alex W Hewitt, Matt Rutar

Biomedicines· May 2025

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Longitudinal Change in Retinal Nerve Fiber Layer Thickness and Intraocular Pressure in Young Adults.
Samantha Sze-Yee Lee, Gareth Lingham, Alex W Hewitt, David A Mackey

Transl Vis Sci Technol· April 2025

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Polymorphic tandem repeats influence cell type-specific gene expression across the human immune landscape.
Hope A Tanudisastro, Anna S E Cuomo, Ben Weisburd, Matthew Welland, Eleanor Spenceley, Alex W Hewitt

bioRxiv· April 2025

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Reply.
Abadh K Chaurasia, Connor J Greatbatch, Xikun Han, Puya Gharahkhani, David A Mackey, Alex W Hewitt

Ophthalmol Sci· April 2025

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Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy.
Rajya L Gurung, Charvi Nangia, Tengda Cai, Liesel M FitzGerald, Bennet J McComish, Alex W Hewitt

Invest Ophthalmol Vis Sci· March 2025

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THE FIGHT INHERITED RETINAL BLINDNESS! PROJECT: A New Treatment Outcome and Natural History Registry for Inherited Retinal Disease.
Matthew P Simunovic, Anthony T Moore, John Grigg, Panagiotis Sergouniotis, Omar A Mahroo, Alex Hewitt

Retina· February 2025

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A large-scale genome-wide association meta-analysis for nevus count provides direct insights into the genetics of melanoma.
G J M S R Jayasinghe, Gu Zhu, Nirmala Pandeya, Catherine M Olsen, Nicholas G Martin, Alex W Hewitt

medRxiv· February 2025

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A generalised computer vision model for improved glaucoma screening using fundus images.
Abadh K Chaurasia, Guei-Sheung Liu, Connor J Greatbatch, Puya Gharahkhani, Jamie E Craig, Alex W Hewitt

Eye (Lond)· January 2025

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Developing and validating a comprehensive polygenic risk score to enhance keratoconus risk prediction.
Weixiong He, Urmo Võsa, Teele Palumaa, Jue-Sheng Ong, Santiago Diaz Torres, Alex W Hewitt

Hum Mol Genet· January 2025

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Predictive Power of Polygenic Risk Scores for Intraocular Pressure or Vertical Cup-Disc Ratio.
Weixiong He, Samantha Sze-Yee Lee, Santiago Diaz Torres, Xikun Han, Puya Gharahkhani, Alex W Hewitt

JAMA Ophthalmol· January 2025

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Genetic and Cellular Basis of Impaired Phagocytosis and Photoreceptor Degeneration in CLN3 Disease.
Jimin Han, Sueanne Chear, Jana Talbot, Vicki Swier, Clarissa Booth, Alex W Hewitt

Invest Ophthalmol Vis Sci· November 2024

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Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma.
Santiago Diaz-Torres, Weixiong He, Regina Yu, , Anthony P Khawaja, Alex W Hewitt

Nat Commun· November 2024

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