Publications by authors named "Alex Mann"

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Prophylactic Efficacy of CD388, a Novel Drug-Fc Conjugate, in a Human Influenza A/H3N2 Virus Challenge Model: A Randomized, Controlled Phase 2a Study.
Roxana E Rojas, Ozlem Equils, Jorge Villacian, Alex Mann, Wilbert van Duijnhoven

Clin Infect Dis· December 2025

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Human Challenge Trial of a Nucleoside-Modified Messenger Ribonucleic Acid Influenza Vaccine.
Kelly A Lindert, Alex Mann, Anita Geevarughese, Teresa Hauguel, Sarah Mirza

NEJM Evid· December 2025

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Pre-existing and early cellular immune factors correlate with functionally complete protection against primary controlled human SARS-CoV-2 infection.
Helen R Wagstaffe, Ryan S Thwaites, Jasmin K Sidhu, Rik G H Lindeboom, Lorenz Kretschmer, Alex Mann, Sarah A Teichmann

Nat Commun· December 2025

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Feasibility and Safety of Aerosolized Influenza Virus Challenge in Humans Using Two Modern Delivery Systems.
Nadine Rouphael, Ralph Tanios, Jessica Traenkner, Matthew D Pauly, Nishit Shetty, Alex Mann

J Infect Dis· December 2025

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Correction for Shetty et al., "Influenza virus infection and aerosol shedding kinetics in a controlled human infection model".
Nishit Shetty, Meredith J Shephard, Nicole C Rockey, Hollie Macenczak, Jessica Traenkner, Alex Mann

J Virol· November 2025

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Controlled human influenza infection reveals heterogeneous expulsion of infectious virus into air.
Nahara Vargas-Maldonado, Nishit Shetty, Lucas M Ferreri, Matthew D Pauly, Kayle Patatanian, Alex Mann

medRxiv· November 2025

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Effective Aerosol Inoculation of Dose-Escalated Seasonal Influenza H3N2 Virus in Controlled Human Infection Model.
Nadine Rouphael, Ralph Tanios, Jessica Traenkner, Matthew D Pauly, Nishit Shetty, Alex Mann

medRxiv· July 2025

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A Phase 2a, Randomized, Placebo-Controlled Human Challenge Trial to Evaluate the Efficacy and Safety of Molnupiravir in Healthy Participants Inoculated with Respiratory Syncytial Virus.
Mickie H Cheng, Alex J Mann, Brian M Maas, Tian Zhao, Melissa Bevan

Pulm Ther· June 2025

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Correction: A Phase 2a, Randomized, Placebo-Controlled Human Challenge Trial to Evaluate the Efficacy and Safety of Molnupiravir in Healthy Participants Inoculated with Respiratory Syncytial Virus.
Mickie H Cheng, Alex J Mann, Brian M Maas, Tian Zhao, Melissa Bevan

Pulm Ther· June 2025

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Next generation bioelectronic medicine: making the case for non-invasive closed-loop autonomic neuromodulation.
Imanuel Lerman, Yifeng Bu, Rahul Singh, Harold A Silverman, Anuj Bhardwaj, Alex J Mann

Bioelectron Med· January 2025

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SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections.
Joshua Rosenheim, Rishi K Gupta, Clare Thakker, Tiffeney Mann, Lucy C K Bell, Alex J Mann, Sarah A Teichmann

Nat Commun· November 2024

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Changes in memory and cognition during the SARS-CoV-2 human challenge study.
William Trender, Peter J Hellyer, Ben Killingley, Mariya Kalinova, Alex J Mann

EClinicalMedicine· October 2024

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Mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge in seronegative adults.
Helen R Wagstaffe, Ryan S Thwaites, Arnold Reynaldi, Jasmin K Sidhu, Richard McKendry, Alex Mann

Sci Immunol· September 2024

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Author Correction: Human SARS-CoV-2 challenge uncovers local and systemic response dynamics.
Rik G H Lindeboom, Kaylee B Worlock, Lisa M Dratva, Masahiro Yoshida, David Scobie, Alex Mann, Sarah A Teichmann

Nature· August 2024

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Human SARS-CoV-2 challenge uncovers local and systemic response dynamics.
Rik G H Lindeboom, Kaylee B Worlock, Lisa M Dratva, Masahiro Yoshida, David Scobie, Alex Mann, Sarah A Teichmann

Nature· July 2024

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Viral emissions into the air and environment after SARS-CoV-2 human challenge: a phase 1, open label, first-in-human study.
Jie Zhou, Anika Singanayagam, Niluka Goonawardane, Maya Moshe, Fiachra P Sweeney, Alex J Mann

Lancet Microbe· August 2023

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Vaccine Efficacy in Adults in a Respiratory Syncytial Virus Challenge Study.
Beate Schmoele-Thoma, Agnieszka M Zareba, Qin Jiang, Mohan S Maddur, Rana Danaf, Alex Mann

N Engl J Med· June 2022

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Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults.
Ben Killingley, Alex J Mann, Mariya Kalinova, Alison Boyers, Niluka Goonawardane

Nat Med· May 2022

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Human infection studies: Key considerations for challenge agent development and production.
Shobana Balasingam, Sarah Meillon, Cecilia Chui, Alex Mann, Carine La

Wellcome Open Res· April 2022

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Controlled Human Infection Studies: Proposals for guidance on how to design, develop and produce a challenge strain.
Isabelle Bekeredjian-Ding, Jean-Hugues Trouvin, Hilde Depraetere, Carine La, Akamol E Suvarnapunya, Alex Mann

Biologicals· November 2021

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Inhibition of viral and bacterial trigger-stimulated prostaglandin E by a throat lozenge containing flurbiprofen: An in vitro study using a human respiratory epithelial cell line.
Rob Lambkin-Williams, Alex Mann, Adrian Shephard

SAGE Open Med· September 2020

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The Effect of Influenza Virus on the Human Oropharyngeal Microbiome.
Elisa Ramos-Sevillano, William G Wade, Alex Mann, Anthony Gilbert, Robert Lambkin-Williams

Clin Infect Dis· May 2019

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The manufacturing of human viral challenge agents for use in clinical studies to accelerate the drug development process.
Andrew P Catchpole, Daniel J Fullen, Nicolas Noulin, Alex Mann, Anthony S Gilbert

BMC Res Notes· August 2018

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The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics.
Rob Lambkin-Williams, Nicolas Noulin, Alex Mann, Andrew Catchpole, Anthony S Gilbert

Respir Res· June 2018

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An Intranasal Proteosome-Adjuvanted Trivalent Influenza Vaccine Is Safe, Immunogenic & Efficacious in the Human Viral Influenza Challenge Model. Serum IgG & Mucosal IgA Are Important Correlates of Protection against Illness Associated with Infection.
Rob Lambkin-Williams, Colin Gelder, Richard Broughton, Corey P Mallett, Anthony S Gilbert, Alex Mann

PLoS One· July 2017

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