Publications by authors named "Alexander C Drohat"

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Thymine DNA Glycosylase Binds to R-Loops and Excises 5-Formyl and 5-Carboxyl Cytosine from DNA/RNA Hybrids.
Baiyu Zhu, Lakshmi S Pidugu, Mary E Cook, Xinyu Y Nie, E A P Tharaka Amarasekara, Alexander C Drohat

bioRxiv· August 2025

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Characterizing the excision of 7,8-dihydro-8-oxoadenine by thymine DNA glycosylase.
Hardler W Servius, Alexander C Drohat

J Biol Chem· July 2025

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Observing nucleotide flipping in DNA using indirect 2'-F nucleotide probes and 19F NMR.
Lakshmi S Pidugu, Erin E Gustafson, Hardler W Servius, Mary E Cook, Nina C Lee, Alexander C Drohat

Nucleic Acids Res· June 2025

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Sumoylation of thymine DNA glycosylase impairs productive binding to substrate sites in DNA.
Lakshmi S Pidugu, Hardler W Servius, Kurt B Espinosa, Mary E Cook, Kristen M Varney, Alexander C Drohat

J Biol Chem· November 2024

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Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine.
Brittani L Schnable, Matthew A Schaich, Vera Roginskaya, Liam P Leary, Tyler M Weaver, Alexander C Drohat

Nat Commun· October 2024

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Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine.
Brittani L Schnable, Matthew A Schaich, Vera Roginskaya, Liam P Leary, Tyler M Weaver, Alexander C Drohat

bioRxiv· July 2024

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Rapid excision of oxidized adenine by human thymine DNA glycosylase.
Hardler W Servius, Lakshmi S Pidugu, Matthew E Sherman, Alexander C Drohat

J Biol Chem· January 2023

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Characterizing inhibitors of human AP endonuclease 1.
Lakshmi S Pidugu, Hardler W Servius, Spiridon E Sevdalis, Mary E Cook, Kristen M Varney, Alexander C Drohat

PLoS One· January 2023

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Structural Insights into the Mechanism of Base Excision by MBD4.
Lakshmi S Pidugu, Hilary Bright, Wen-Jen Lin, Chandrima Majumdar, Robert P Van Ostrand, Alexander C Drohat

J Mol Biol· July 2021

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TET-TDG Active DNA Demethylation at CpG and Non-CpG Sites.
Jamie E DeNizio, Blaine J Dow, Juan C Serrano, Uday Ghanty, Alexander C Drohat

J Mol Biol· April 2021

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Excision of 5-Carboxylcytosine by Thymine DNA Glycosylase.
Lakshmi S Pidugu, Qing Dai, Shuja S Malik, Edwin Pozharski, Alexander C Drohat

J Am Chem Soc· November 2019

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Defining the Role of Nucleotide Flipping in Enzyme Specificity Using F NMR.
Blaine J Dow, Shuja S Malik, Alexander C Drohat

J Am Chem Soc· March 2019

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Nucleosomes and the three glycosylases: High, medium, and low levels of excision by the uracil DNA glycosylase superfamily.
Mary E Tarantino, Blaine J Dow, Alexander C Drohat, Sarah Delaney

DNA Repair (Amst)· December 2018

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Defining the impact of sumoylation on substrate binding and catalysis by thymine DNA glycosylase.
Christopher T Coey, Alexander C Drohat

Nucleic Acids Res· June 2018

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Kinetic Methods for Studying DNA Glycosylases Functioning in Base Excision Repair.
Christopher T Coey, Alexander C Drohat

Methods Enzymol· April 2018

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Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues.
Christopher T Coey, Shuja S Malik, Lakshmi S Pidugu, Kristen M Varney, Edwin Pozharski, Alexander C Drohat

Nucleic Acids Res· December 2016

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Structural Basis for Excision of 5-Formylcytosine by Thymine DNA Glycosylase.
Lakshmi S Pidugu, Joshua W Flowers, Christopher T Coey, Edwin Pozharski, Marc M Greenberg, Alexander C Drohat

Biochemistry· November 2016

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Role of Base Excision "Repair" Enzymes in Erasing Epigenetic Marks from DNA.
Alexander C Drohat, Christopher T Coey

Chem Rev· October 2016

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Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase.
Daniel R Semlow, Jieqiong Zhang, Magda Budzowska, Alexander C Drohat, Johannes C Walter

Cell· October 2016

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Characterizing Requirements for Small Ubiquitin-like Modifier (SUMO) Modification and Binding on Base Excision Repair Activity of Thymine-DNA Glycosylase in Vivo.
Dylan McLaughlin, Christopher T Coey, Wei-Chih Yang, Alexander C Drohat, Michael J Matunis

J Biol Chem· April 2016

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Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA.
Shuja S Malik, Christopher T Coey, Kristen M Varney, Edwin Pozharski, Alexander C Drohat

Nucleic Acids Res· October 2015

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Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites.
Alfonso Bellacosa, Alexander C Drohat

DNA Repair (Amst)· August 2015

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Lesion search and recognition by thymine DNA glycosylase revealed by single molecule imaging.
Claudia N Buechner, Atanu Maiti, Alexander C Drohat, Ingrid Tessmer

Nucleic Acids Res· March 2015

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Mechanisms for enzymatic cleavage of the N-glycosidic bond in DNA.
Alexander C Drohat, Atanu Maiti

Org Biomol Chem· November 2014

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E2-mediated small ubiquitin-like modifier (SUMO) modification of thymine DNA glycosylase is efficient but not selective for the enzyme-product complex.
Christopher T Coey, Megan E Fitzgerald, Atanu Maiti, Katherine H Reiter, Catherine M Guzzo, Alexander C Drohat

J Biol Chem· May 2014

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