Publications by authors named "Alexander F Shaffer"

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Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation.
Graciela B Arhancet, Daniel P Walker, Sue Metz, Yvette M Fobian, Steven E Heasley, Alexander F Shaffer

Bioorg Med Chem Lett· February 2013

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Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: use of a conformation-based hypothesis to facilitate compound design.
Daniel P Walker, Graciela B Arhancet, Hwang-Fun Lu, Steven E Heasley, Sue Metz, Alexander F Shaffer

Bioorg Med Chem Lett· February 2013

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Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis.
Stephen J Mnich, Patrick M Blanner, Liangbiao G Hu, Alexander F Shaffer, Fernando A Happa

Int Immunopharmacol· October 2010

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Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor.
Gabriel Mbalaviele, Adele M Pauley, Alexander F Shaffer, Ben S Zweifel, Sumathy Mathialagan

Biochem Pharmacol· May 2010

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A novel, highly selective, tight binding IkappaB kinase-2 (IKK-2) inhibitor: a tool to correlate IKK-2 activity to the fate and functions of the components of the nuclear factor-kappaB pathway in arthritis-relevant cells and animal models.
Gabriel Mbalaviele, Cynthia D Sommers, Sheri L Bonar, Sumathy Mathialagan, John F Schindler, Alexander F Shaffer

J Pharmacol Exp Ther· April 2009

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