Publications by authors named "Alexander Lemak"

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The RavA-ViaA chaperone complex modulates bacterial persistence through its association with the fumarate reductase enzyme.
Vaibhav Bhandari, Sean E Reichheld, Scott Houliston, Alexander Lemak, Cheryl H Arrowsmith

J Biol Chem· October 2023

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Dissecting the stability determinants of a challenging de novo protein fold using massively parallel design and experimentation.
Tae-Eun Kim, Kotaro Tsuboyama, Scott Houliston, Cydney M Martell, Claire M Phoumyvong, Alexander Lemak

Proc Natl Acad Sci U S A· October 2022

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Phosphorylation of the DNA repair scaffold SLX4 drives folding of the SAP domain and activation of the MUS81-EME1 endonuclease.
Brandon J Payliss, Ying Wah E Tse, Sean E Reichheld, Alexander Lemak, Hwa Young Yun

Cell Rep· October 2022

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The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase.
Yong Wei, Cornelia Redel, Alexandra Ahlner, Alexander Lemak, Isak Johansson-Åkhe

Nucleic Acids Res· April 2022

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Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1.
Rachel J Harding, Justin C Deme, Johannes F Hevler, Sem Tamara, Alexander Lemak

Commun Biol· December 2021

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Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1.
Maria Tauber, Sarah Kreuz, Alexander Lemak, Papita Mandal, Zhadyra Yerkesh

Nucleic Acids Res· August 2020

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The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions.
Lilia Kaustov, Alexander Lemak, Hong Wu, Marco Faini, Lixin Fan

Nucleic Acids Res· September 2019

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Design and characterization of mutant and wildtype huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems.
Rachel J Harding, Peter Loppnau, Suzanne Ackloo, Alexander Lemak, Ashley Hutchinson

J Biol Chem· April 2019

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Functional diversification of the NleG effector family in enterohemorrhagic .
Dylan Valleau, Dustin J Little, Dominika Borek, Tatiana Skarina, Andrew T Quaile, Alexander Lemak

Proc Natl Acad Sci U S A· October 2018

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Conformational dynamics of the TTD-PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability.
R Scott Houliston, Alexander Lemak, Aman Iqbal, Danton Ivanochko, Shili Duan

J Biol Chem· December 2017

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Solution NMR structure of the TRIM21 B-box2 and identification of residues involved in its interaction with the RING domain.
Amélie Wallenhammar, Madhanagopal Anandapadamanaban, Alexander Lemak, Claudio Mirabello, Patrik Lundström

PLoS One· October 2017

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Global analysis of protein folding using massively parallel design, synthesis, and testing.
Gabriel J Rocklin, Tamuka M Chidyausiku, Inna Goreshnik, Alex Ford, Scott Houliston, Alexander Lemak

Science· July 2017

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The second round of Critical Assessment of Automated Structure Determination of Proteins by NMR: CASD-NMR-2013.
Antonio Rosato, Wim Vranken, Rasmus H Fogh, Timothy J Ragan, Roberto Tejero, Alexander Lemak

J Biomol NMR· August 2015

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Structural and functional characterization of DUF1471 domains of Salmonella proteins SrfN, YdgH/SssB, and YahO.
Alexander Eletsky, Karolina Michalska, Scott Houliston, Qi Zhang, Michael D Daily, Alexander Lemak

PLoS One· March 2015

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Structural characterization of a flexible two-domain protein in solution using small angle X-ray scattering and NMR data.
Alexander Lemak, Bin Wu, Adelinda Yee, Scott Houliston, Hsiau-Wei Lee

Structure· December 2014

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Solution NMR structure and histone binding of the PHD domain of human MLL5.
Alexander Lemak, Adelinda Yee, Hong Wu, Damian Yap, Hong Zeng

PLoS One· June 2014

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Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate.
Kathy A Gelato, Maria Tauber, Michelle S Ong, Stefan Winter, Kyoko Hiragami-Hamada, Alexander Lemak

Mol Cell· June 2014

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Basic Tilted Helix Bundle - a new protein fold in human FKBP25/FKBP3 and HectD1.
Sara Helander, Meri Montecchio, Alexander Lemak, Christophe Farès, Jonas Almlöf

Biochem Biophys Res Commun· April 2014

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Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding.
Cecilia Andresen, Sara Helander, Alexander Lemak, Christophe Farès, Veronika Csizmok

Nucleic Acids Res· July 2012

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Solution NMR structure, backbone dynamics, and heme-binding properties of a novel cytochrome c maturation protein CcmE from Desulfovibrio vulgaris.
James M Aramini, Keith Hamilton, Paolo Rossi, Asli Ertekin, Hsiau-Wei Lee, Alexander Lemak

Biochemistry· May 2012

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Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A.
Alexander Lemak, Adelinda Yee, Irina Bezsonova, Sirano Dhe-Paganon, Cheryl H Arrowsmith

J Biomol NMR· September 2011

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Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein.
Nataliya Nady, Alexander Lemak, John R Walker, George V Avvakumov, Michael S Kareta

J Biol Chem· July 2011

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Recognition and specificity determinants of the human cbx chromodomains.
Lilia Kaustov, Hui Ouyang, Maria Amaya, Alexander Lemak, Nataliya Nady

J Biol Chem· January 2011

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A novel strategy for NMR resonance assignment and protein structure determination.
Alexander Lemak, Aleksandras Gutmanas, Seth Chitayat, Murthy Karra, Christophe Farès

J Biomol NMR· January 2011

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NleG Type 3 effectors from enterohaemorrhagic Escherichia coli are U-Box E3 ubiquitin ligases.
Bin Wu, Tatiana Skarina, Adelinda Yee, Marie-Claude Jobin, Rosa Dileo, Alexander Lemak

PLoS Pathog· June 2010

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