Publications by authors named "Alexander Mankin"

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Saskemycin, a potent and selective antimycobacterial agent targeting a unique site on the ribosome.
Gerard Wright, Michael Cook, Min Xu, Martino Morici, Dmitrii Travin, Alexander Mankin

Res Sq· November 2025

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Author Correction: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome.
Manoj Jangra, Dmitrii Y Travin, Elena V Aleksandrova, Manpreet Kaur, Lena Darwish, Alexander S Mankin

Nature· September 2025

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Sequence-specific trapping of EF-Tu/glycyl-tRNA complex on the ribosome by bottromycin.
Dmitrii Y Travin, Ritwika S Basu, Madhura N Paranjpe, Dorota Klepacki, Anna I Zhurakovskaya, Alexander S Mankin

bioRxiv· August 2025

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A Natural Depsipeptide Antibiotic that Targets the E site of the Bacterial Ribosome.
Gerard Wright, Manpreet Kaur, Dmitrii Travin, Max Berger, Manoj Jangra, Alexander Mankin

Res Sq· July 2025

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A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome.
Manoj Jangra, Dmitrii Y Travin, Elena V Aleksandrova, Manpreet Kaur, Lena Darwish, Alexander S Mankin

Nature· April 2025

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Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR).
Gary Loughran, Dmitry E Andreev, Ilya M Terenin, Olivier Namy, Martin Mikl, Alexander S Mankin

Nat Struct Mol Biol· March 2025

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Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Elena V Aleksandrova, Cong-Xuan Ma, Dorota Klepacki, Faezeh Alizadeh, Nora Vázquez-Laslop, Alexander S Mankin

Nat Chem Biol· December 2024

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Paenilamicins are context-specific translocation inhibitors of protein synthesis.
Timm O Koller, Max J Berger, Martino Morici, Helge Paternoga, Timur Bulatov, Alexander S Mankin

Nat Chem Biol· December 2024

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Activity, structure, and diversity of Type II proline-rich antimicrobial peptides from insects.
Weiping Huang, Chetana Baliga, Elena V Aleksandrova, Gemma Atkinson, Yury S Polikanov, Alexander S Mankin

EMBO Rep· November 2024

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A Broad Spectrum Lasso Peptide Antibiotic Targeting the Bacterial Ribosome.
Gerard Wright, Manoj Jangra, Dmitrii Travin, Elena Aleksandrova, Manpreet Kaur, Alexander Mankin

Res Sq· September 2024

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Sequence diversity of apidaecin-like peptides arresting the terminating ribosome.
Weiping Huang, Chetana Baliga, Nora Vázquez-Laslop, Alexander S Mankin

Nucleic Acids Res· August 2024

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Paenilamicins from the honey bee pathogen are context-specific translocation inhibitors of protein synthesis.
Timm O Koller, Max J Berger, Martino Morici, Helge Paternoga, Timur Bulatov, Alexander Mankin

bioRxiv· May 2024

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Peptidyl-tRNA hydrolase is the nascent chain release factor in bacterial ribosome-associated quality control.
Maxim S Svetlov, Clémence F Dunand, Jose A Nakamoto, Gemma C Atkinson, Haaris A Safdari, Alexander S Mankin

Mol Cell· February 2024

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Inhibition of translation termination by the antimicrobial peptide Drosocin.
Kyle Mangano, Dorota Klepacki, Irueosa Ohanmu, Chetana Baliga, Weiping Huang, Alexander S Mankin

Nat Chem Biol· September 2023

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Structure-Activity Relationships of the Antimicrobial Peptide Natural Product Apidaecin.
Kornelia J Skowron, Chetana Baliga, Tatum Johnson, Kyle M Kremiller, Alexandra Castroverde, Alexander S Mankin

J Med Chem· September 2023

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A method for tritiation of iboxamycin permits measurement of its ribosomal binding.
Kelvin J Y Wu, Dorota Klepacki, Alexander S Mankin, Andrew G Myers

Bioorg Med Chem Lett· July 2023

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Context-based sensing of orthosomycin antibiotics by the translating ribosome.
Kyle Mangano, James Marks, Dorota Klepacki, Chayan Kumar Saha, Gemma C Atkinson, Alexander S Mankin

Nat Chem Biol· November 2022

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Response to: Lack of evidence for ribosomal frameshifting in ATP7B mRNA decoding.
Sezen Meydan, Dorota Klepacki, Subbulakshmi Karthikeyan, Tõnu Margus, Paul Thomas, Alexander S Mankin

Mol Cell· October 2022

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Discovery of Unannotated Small Open Reading Frames in Streptococcus pneumoniae D39 Involved in Quorum Sensing and Virulence Using Ribosome Profiling.
Irina Laczkovich, Kyle Mangano, Xinhao Shao, Adam J Hockenberry, Yu Gao, Alexander Mankin

mBio· August 2022

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Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics.
Kaitlyn Tsai, Vanja Stojković, D John Lee, Iris D Young, Teresa Szal, Alexander S Mankin

Nat Struct Mol Biol· February 2022

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Identifying Small Open Reading Frames in Prokaryotes with Ribosome Profiling.
Nora Vazquez-Laslop, Cynthia M Sharma, Alexander Mankin, Allen R Buskirk

J Bacteriol· January 2022

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The context of the ribosome binding site in mRNAs defines specificity of action of kasugamycin, an inhibitor of translation initiation.
Yan Zhang, Nikolay A Aleksashin, Dorota Klepacki, Caleb Anderson, Nora Vázquez-Laslop, Alexander S Mankin

Proc Natl Acad Sci U S A· January 2022

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A synthetic antibiotic class overcoming bacterial multidrug resistance.
Matthew J Mitcheltree, Amarnath Pisipati, Egor A Syroegin, Katherine J Silvestre, Dorota Klepacki, Alexander S Mankin

Nature· November 2021

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Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics.
Bertrand Beckert, Elodie C Leroy, Shanmugapriya Sothiselvam, Lars V Bock, Maxim S Svetlov, Alexander S Mankin

Nat Commun· July 2021

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Context-specific action of macrolide antibiotics on the eukaryotic ribosome.
Maxim S Svetlov, Timm O Koller, Sezen Meydan, Vaishnavi Shankar, Dorota Klepacki, Alexander S Mankin

Nat Commun· May 2021

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