Publications by authors named "Alexander Pasternak"

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Doubling dolutegravir dosage reduces the viral reservoir in ART-treated people with HIV.
Céline Fombellida-Lopez, Aurelija Valaitienė, Lee Winchester, Nathalie Maes, Patricia Dellot, Alexander O Pasternak

medRxiv· October 2025

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No associations between HIV reservoir and inflammation in long-term virally suppressed dolutegravir-based ART-treated individuals.
Céline Fombellida-Lopez, Diego Aguilar Ortmans, Michel Moutschen, Alexander O Pasternak, Gilles Darcis

Front Immunol· August 2025

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Long-term effect of temporary ART initiated during primary HIV-1 infection on viral persistence.
Alexander O Pasternak, Pien M van Paassen, Yara L Verschoor, Jelmer Vroom, Karel A van Dort

Nat Commun· July 2025

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Soluble CD14 and IL-12p70 on early antiretroviral therapy predict HIV load setpoint after treatment interruption.
Pien M van Paassen, Anders C Boyd, Alexander O Pasternak, Irma Maurer, Agnes M Harskamp

AIDS· June 2025

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Inhibition of ALKBH5 demethylase of mA pathway potentiates HIV-1 reactivation from latency.
Haider Ali, Jakub Wadas, Maryam Bendoumou, Heng-Chang Chen, Paolo Maiuri, Alexander O Pasternak

Virol J· April 2025

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Phenotyping Viral Reservoirs to Reveal HIV-1 Hiding Places.
Wenxuan Chen, Ben Berkhout, Alexander O Pasternak

Curr HIV/AIDS Rep· February 2025

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Nuclear retention of unspliced HIV-1 RNA as a reversible post-transcriptional block in latency.
Agnieszka Dorman, Maryam Bendoumou, Aurelija Valaitienė, Jakub Wadas, Haider Ali, Alexander O Pasternak

Nat Commun· February 2025

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Soluble markers of viral rebound and post-treatment HIV control.
Leila B Giron, Alexander O Pasternak, Mohamed Abdel-Mohsen

Curr Opin HIV AIDS· January 2025

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Discovery of sulfone containing metallo-β-lactamase inhibitors with reduced bacterial cell efflux and histamine release issues.
Frank Bennett, Yuhua Huang, Shuzhi Dong, Jinlong Jiang, David Hunter, Alexander Pasternak

Bioorg Med Chem Lett· December 2024

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Persistent HIV-1 transcription during ART: time to reassess its significance?
Céline Fombellida-Lopez, Ben Berkhout, Gilles Darcis, Alexander O Pasternak

Curr Opin HIV AIDS· May 2024

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Live cell screening to identify RNA-binding small molecule inhibitors of the pre-let-7-Lin28 RNA-protein interaction.
Sydney L Rosenblum, Dalia M Soueid, George Giambasu, Steve Vander Roest, Alexander Pasternak

RSC Med Chem· May 2024

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Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
Shuzhi Dong, Zhiqiang Zhao, Haiqun Tang, Guoqing Li, Jianping Pan, Alexander Pasternak

J Med Chem· March 2024

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'Zombie' proviruses in the spotlight: exploring the dark side of HIV persistence.
Alexander O Pasternak, Tetsuo Tsukamoto, Ben Berkhout

AIDS· November 2023

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FcγRIIA-specific DARPins as novel tools in blood cell analysis and platelet aggregation.
Vanessa Riechert, Sascha Hein, Mayken Visser, Mathias Zimmermann, Jan Wesche, Alexander O Pasternak

J Biol Chem· June 2023

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Corrigendum: Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency.
Alexander O Pasternak, Olivier Rohr, Carine Van Lint, Anna Kula-Pacurar

Front Cell Infect Microbiol· May 2023

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HIV persistence: silence or resistance?
Alexander O Pasternak, Ben Berkhout

Curr Opin Virol· April 2023

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Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency.
Alexander O Pasternak, Olivier Rohr, Carine Van Lint, Anna Kula-Pacurar

Front Cell Infect Microbiol· April 2023

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Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
Mihirbaran Mandal, Li Xiao, Weidong Pan, Giovanna Scapin, Guoqing Li, Alexander Pasternak

J Med Chem· December 2022

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Towards a molecular profile of antiretroviral therapy-free HIV remission.
Philipp Adams, Ben Berkhout, Alexander O Pasternak

Curr Opin HIV AIDS· September 2022

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Novel role of UHRF1 in the epigenetic repression of the latent HIV-1.
Roxane Verdikt, Maryam Bendoumou, Sophie Bouchat, Lorena Nestola, Alexander O Pasternak

EBioMedicine· May 2022

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Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing.
Derun Li, David L Sloman, Abdelghani Achab, Hua Zhou, Meredeth A McGowan, Alexander Pasternak

J Med Chem· April 2022

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The Splice of Life: Does RNA Processing Have a Role in HIV-1 Persistence?
Alexander O Pasternak, Ben Berkhout

Viruses· September 2021

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Naive infection predicts reservoir diversity and is a formidable hurdle to HIV eradication.
Marilia R Pinzone, Sam Weissman, Alexander O Pasternak, Ryan Zurakowski, Stephen Migueles

JCI Insight· August 2021

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Non-nucleoside reverse transcriptase inhibitor-based combination antiretroviral therapy is associated with lower cell-associated HIV RNA and DNA levels compared to protease inhibitor-based therapy.
Alexander O Pasternak, Jelmer Vroom, Neeltje A Kootstra, Ferdinand Wnm Wit, Marijn de Bruin

Elife· August 2021

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Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic.
Jinlong Jiang, Fa-Xiang Ding, Xiaoyan Zhou, Thomas J Bateman, Shuzhi Dong, Alexander Pasternak

J Med Chem· June 2021

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