Publications by authors named "Alexander Polyzos"

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Enhancer remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm.
Ly-Sha Ee, Daniel Medina-Cano, Emily Goetzler, Christopher Uyehara, Clayton Schwarz, Alexander Polyzos

Dev Cell· December 2025

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Coordinated repression of totipotency-associated gene loci by histone methyltransferase EHMT2 via LINE1 regulatory elements.
Kaushiki Chatterjee, Christopher Mitsuo Uyehara, Kritika Kasliwal, Subhashini Madhuranath, Laurianne Scourzic, Alexander Polyzos

EMBO Rep· December 2025

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Disruption of TAD hierarchy promotes LTR co-option in cancer.
Elissa W P Wong, Merve Sahin, Rui Yang, UkJin Lee, Dan Li, Alexander Polyzos

Nat Genet· July 2025

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Three-dimensional regulatory hubs support oncogenic programs in glioblastoma.
Sarah L Breves, Dafne Campigli Di Giammartino, James Nicholson, Stefano Cirigliano, Syed Raza Mahmood, Alexander Polyzos

Mol Cell· April 2025

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Single-cell analysis of bidirectional reprogramming between early embryonic states identify mechanisms of differential lineage plasticities in mice.
Vidur Garg, Yang Yang, Sonja Nowotschin, Manu Setty, Eralda Salataj, Alexander Polyzos

Dev Cell· March 2025

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3D chromatin hubs as regulatory units of identity and survival in human acute leukemia.
Giovanni Gambi, Francesco Boccalatte, Javier Rodriguez Hernaez, Ziyan Lin, Bettina Nadorp, Alexander Polyzos

Mol Cell· January 2025

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An Unbiased Approach to Identifying Cellular Reprogramming-Inducible Enhancers.
Eleftheria Klagkou, Dimitrios Valakos, Spyros Foutadakis, Alexander Polyzos, Angeliki Papadopoulou

Int J Mol Sci· December 2024

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Three-dimensional regulatory hubs support oncogenic programs in glioblastoma.
Sarah L Breves, Dafne Campigli Di Giammartino, James Nicholson, Stefano Cirigliano, Syed Raza Mahmood, Alexander Polyzos

bioRxiv· December 2024

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TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer.
Elissa W P Wong, Merve Sahin, Rui Yang, UkJin Lee, Yingqian A Zhan, Alexander Polyzos

bioRxiv· June 2024

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3D Enhancer-promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages.
Dylan Murphy, Eralda Salataj, Dafne Campigli Di Giammartino, Javier Rodriguez-Hernaez, Andreas Kloetgen, Alexander Polyzos

Nat Struct Mol Biol· January 2024

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Systematic mapping and modeling of 3D enhancer-promoter interactions in early mouse embryonic lineages reveal regulatory principles that determine the levels and cell-type specificity of gene expression.
Dylan Murphy, Eralda Salataj, Dafne Campigli Di Giammartino, Javier Rodriguez-Hernaez, Andreas Kloetgen, Alexander Polyzos

bioRxiv· July 2023

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Single-cell analysis of bidirectional reprogramming between early embryonic states reveals mechanisms of differential lineage plasticities.
Vidur Garg, Yang Yang, Sonja Nowotschin, Manu Setty, Ying-Yi Kuo, Alexander Polyzos

bioRxiv· March 2023

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A Knock-In Mouse Model of Thymoma With the GTF2I L424H Mutation.
Yongfeng He, In-Kyu Kim, Jing Bian, Alexander Polyzos, Dafne Campigli Di Giammartino

J Thorac Oncol· December 2022

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Assessing Specific Networks of Chromatin Interactions with HiChIP.
Dafne Campigli Di Giammartino, Alexander Polyzos, Effie Apostolou

Methods Mol Biol· July 2022

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Author Correction: Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.
Panagiotis Galanos, George Pappas, Alexander Polyzos, Athanassios Kotsinas, Ioanna Svolaki

Genome Biol· April 2022

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A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus.
Boaz E Aronson, Laurianne Scourzic, Veevek Shah, Emily Swanzey, Andreas Kloetgen, Alexander Polyzos

Dev Cell· November 2021

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Correction to: A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence.
Eirini-Stavroula Komseli, Ioannis S Pateras, Thorbjørn Krejsgaard, Konrad Stawiski, Sophia V Rizou, Alexander Polyzos

BMC Genomics· May 2021

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H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization.
Bobbie Pelham-Webb, Alexander Polyzos, Luke Wojenski, Andreas Kloetgen, Jiexi Li

Mol Cell· April 2021

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Identification of a dynamic gene regulatory network required for pluripotency factor-induced reprogramming of mouse fibroblasts and hepatocytes.
Maria Papathanasiou, Stefanos A Tsiftsoglou, Alexander P Polyzos, Deppie Papadopoulou, Dimitrios Valakos

EMBO J· January 2021

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Context-Dependent Requirement of Euchromatic Histone Methyltransferase Activity during Reprogramming to Pluripotency.
Simon E Vidal, Alexander Polyzos, Kaushiki Chatterjee, Ly-Sha Ee, Emily Swanzey

Stem Cell Reports· December 2020

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Transcription factors: building hubs in the 3D space.
Dafne Campigli Di Giammartino, Alexander Polyzos, Effie Apostolou

Cell Cycle· October 2020

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CHUK/IKK-α loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulation.
Evangelia Chavdoula, David M Habiel, Eugenia Roupakia, Georgios S Markopoulos, Eleni Vasilaki, Alexander P Polyzos

Life Sci Alliance· December 2019

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A Deep Learning Framework for Predicting Response to Therapy in Cancer.
Theodore Sakellaropoulos, Konstantinos Vougas, Sonali Narang, Filippos Koinis, Athanassios Kotsinas, Alexander Polyzos

Cell Rep· December 2019

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Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining.
Konstantinos Vougas, Theodore Sakellaropoulos, Athanassios Kotsinas, George-Romanos P Foukas, Andreas Ntargaras, Alexander Polyzos

Pharmacol Ther· November 2019

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KLF4 is involved in the organization and regulation of pluripotency-associated three-dimensional enhancer networks.
Dafne Campigli Di Giammartino, Andreas Kloetgen, Alexander Polyzos, Yiyuan Liu, Daleum Kim

Nat Cell Biol· October 2019

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