Publications by authors named "Alexander Tikhomirov"

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Rational design of 1H-pyrrole-2-carboxylic acid inhibitors of NDM-1 metallo-β-lactamase restoring β-lactam efficacy against resistant Enterobacterales.
Tatiana S Shkuratova, Kirill V Rychev, Vitaly G Grigorenko, Irina P Andreeva, Natalia E Grammatikova, Alexander S Tikhomirov

Eur J Med Chem· January 2026

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Effect of Carrier Protein Size on Hapten Immunogenicity and Antibody Affinity in Mice.
Maksim A Burkin, Valeria A Litvinova, Alexander S Tikhomirov, Elena Y Katarzhnova, Inna A Galvidis

Bioconjug Chem· December 2025

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Analogues of gramicidin S: A promising direction for future antibacterial drug development?
Tatiana S Shkuratova, Daria V Andreeva, Alexander S Tikhomirov, Andrey E Shchekotikhin

Eur J Med Chem· November 2025

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Olivomycin A Targets Epithelial-Mesenchymal Transition, Apoptosis, and Mitochondrial Quality Control in Renal Cancer Cells.
Ching-Yu Hsieh, Yih-Farng Liou, Yu-Tung Shih, Alexander S Tikhomirov, Andrey E Shchekotikhin

Antioxidants (Basel)· November 2025

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Isolation of cyclic decapeptide antibiotics related to gramicidin S.
Alexander S Tikhomirov, Svetlana E Solov'eva, Tatiana S Shkuratova, Natalya M Malyutina, Daria V Andreeva

Nat Prod Res· October 2025

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Discovery of cytotoxic indolo[1,2-]quinazoline derivatives through scaffold-based design.
Daniil Viktorovich Khabarov, Valeria Alexandrovna Litvinova, Lyubov Georgievna Dezhenkova, Dmitry Nikolaevich Kaluzhny, Alexander S Tikhomirov

Beilstein J Org Chem· October 2025

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Naphthoindole-2-carboxamides as a lipophilic chemotype of hetarene-anthraquinones potent against P-gp resistant tumor cells.
Valeria A Litvinova, Vladimir B Tsvetkov, Yulia L Volodina, Lyubov G Dezhenkova, Alina A Markova, Alexander S Tikhomirov

Eur J Med Chem· January 2025

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Synthesis and Antibacterial Activity of New 6″-Modified Tobramycin Derivatives.
Kseniya S Shapovalova, Georgy V Zatonsky, Elizaveta A Razumova, Daria A Ipatova, Dmitrii A Lukianov, Alexander S Tikhomirov

Antibiotics (Basel)· December 2024

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Hapten Synthesis, Antibody Generation, and Immunoassay Development for Linezolid Therapeutic Monitoring.
Maksim A Burkin, Alexander S Tikhomirov, Yury A Surovoy, Inna A Galvidis

Anal Chem· November 2024

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Synthesis and antiproliferative activity of thiazole-fused anthraquinones.
Daria V Andreeva, Alexander S Tikhomirov, Andrey E Shchekotikhin

Org Biomol Chem· October 2024

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Water-soluble 4-(dimethylaminomethyl)heliomycin exerts greater antitumor effects than parental heliomycin by targeting the tNOX-SIRT1 axis and apoptosis in oral cancer cells.
Atikul Islam, Yu-Chun Chang, Xiao-Chi Chen, Chia-Wei Weng, Chien-Yu Chen, Alexander S Tikhomirov

Elife· April 2024

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Thiadiazole-, selenadiazole- and triazole-fused anthraquinones as G-quadruplex targeting anticancer compounds.
Daria V Andreeva, Tatiana S Vedekhina, Alexander S Gostev, Lyubov G Dezhenkova, Yulia L Volodina, Alexander S Tikhomirov

Eur J Med Chem· March 2024

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Synthesis and antitumor activity of cyclopentane-fused anthraquinone derivatives.
Alexander S Tikhomirov, Yuri B Sinkevich, Lyubov G Dezhenkova, Dmitry N Kaluzhny, Nikolay S Ilyinsky

Eur J Med Chem· February 2024

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Hybrid Molecules of Azithromycin with Chloramphenicol and Metronidazole: Synthesis and Study of Antibacterial Properties.
Inna A Volynkina, Elena N Bychkova, Anastasiia O Karakchieva, Alexander S Tikhomirov, George V Zatonsky

Pharmaceuticals (Basel)· January 2024

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Design, Synthesis and In Vitro Investigation of Cabozantinib-Based PROTACs to Target c-Met Kinase.
Anastasia A Sachkova, Daria V Andreeva, Alexander S Tikhomirov, Alexander M Scherbakov, Diana I Salnikova

Pharmaceutics· December 2022

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Computational and Biophysical Characterization of Heterocyclic Derivatives of Anthraquinone against Human Aurora Kinase A.
Mandeep Singh, Md Anzarul Haque, Alexander S Tikhomirov, Andrey E Shchekotikhin, Uddipan Das

ACS Omega· November 2022

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Heterocyclic ring expansion yields anthraquinone derivatives potent against multidrug resistant tumor cells.
Alexander S Tikhomirov, Vladimir B Tsvetkov, Yulia L Volodina, Valeria A Litvinova, Daria V Andreeva

Bioorg Chem· October 2022

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Bis(chloroacetamidino)-Derived Heteroarene-Fused Anthraquinones Bind to and Cause Proteasomal Degradation of tNOX, Leading to c-Flip Downregulation and Apoptosis in Oral Cancer Cells.
Jeng Shiun Chang, Chien-Yu Chen, Alexander S Tikhomirov, Atikul Islam, Ru-Hao Liang

Cancers (Basel)· September 2022

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Photosensitization of pancreatic cancer cells by cationic alkyl-porphyrins in free form or engrafted into POPC liposomes: The relationship between delivery mode and mechanism of cell death.
Eros Di Giorgio, Annalisa Ferino, Himanshi Choudhary, Phillip M G Löffler, Francesca D'Este, Alexander Tikhomirov

J Photochem Photobiol B· June 2022

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Possible risks for the functioning of cyclic processes in the experimental model of a closed ecosystem.
Alexander Tikhomirov, Sofya Ushakova, Vladimir Velichko, Sergey Trifonov, Natalia Tikhomirova

Life Sci Space Res (Amst)· May 2022

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Antibiotic heliomycin and its water-soluble 4-aminomethylated derivative provoke cell death in T24 bladder cancer cells by targeting sirtuin 1 (SIRT1).
Ming Hung Lin, Atikul Islam, Yen-Hui Liu, Chia-Wei Weng, Jun-Han Zhan, Alexander S Tikhomirov

Am J Cancer Res· March 2022

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Thiophene-2-carboxamide derivatives of anthraquinone: A new potent antitumor chemotype.
Yulia L Volodina, Alexander S Tikhomirov, Lyubov G Dezhenkova, Alla A Ramonova, Anastasia V Kononova

Eur J Med Chem· October 2021

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Heterocycloalkynes Fused to a Heterocyclic Core: Searching for an Island with Optimal Stability-Reactivity Balance.
Natalia A Danilkina, Anastasia I Govdi, Alexander F Khlebnikov, Alexander O Tikhomirov, Vladimir V Sharoyko

J Am Chem Soc· October 2021

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Water-Soluble Heliomycin Derivatives to Target i-Motif DNA.
Alexander S Tikhomirov, Mahmoud A S Abdelhamid, Georgy Y Nadysev, George V Zatonsky, Eugene E Bykov

J Nat Prod· May 2021

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Heteroarene-fused anthraquinone derivatives as potential modulators for human aurora kinase B.
Mandeep Singh, Lakshay Malhotra, Md Anzarul Haque, Mukesh Kumar, Alexander Tikhomirov

Biochimie· March 2021

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