Publications by authors named "Alexandre F Aissa"

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Unraveling the Effects of Epigallocatechin-3-gallate on Hepatocellular Carcinoma Cells: A Comparative Analysis of Monolayer vs Multicellular Tumor Spheroids.
Mariana Dos Reis Simpronio, Ana Rita Thomazela Machado, Patrick Santos, Diego Luis Ribeiro, Lusânia Maria Greggi Antunes, Alexandre Ferro Aissa

ACS Omega· August 2025

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Toxigenomic Evaluation of Diallyl Disulfide Effects and Its Association with the Chemotherapeutic Agent 5-Fluorouracil in Colorectal Cancer Cell Lines.
Estefani Maria Treviso, Caroline Andolfato Sanchez, Cecília Cristina Souza Rocha, Alexandre Ferro Aissa, Lusânia Maria Greggi Antunes

Nutrients· July 2025

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Resistance to the KRAS Inhibitor MRTX1133 is Associated with Increased Sensitivity to BET Inhibition.
Daniel R Principe, Jeffrey H Becker, Anastasia E Metropulos, Alejandra M Marinelarena, Thao D Pham, Alexandre F Aissa

bioRxiv· May 2025

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HDAC6 inhibition through WT161 synergizes with temozolomide, induces apoptosis, reduces cell motility, and decreases β-catenin levels in glioblastoma cells.
Leilane Sales Oliveira, João Marcos Oliveira-Silva, Hebreia Oliveira Almeida-Souza, Mario Machado Martins, Carolina Berraut Chiminazo, Alexandre Ferro Aissa

Invest New Drugs· April 2025

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WT161, a selective HDAC6 inhibitor, decreases growth, enhances chemosensitivity, promotes apoptosis, and suppresses motility of melanoma cells.
João Marcos Oliveira-Silva, Leilane Sales Oliveira, Carolina Berraut Chiminazo, Rafael Fonseca, Carlos Vinicius Expedito de Souza, Alexandre Ferro Aissa

Cancer Chemother Pharmacol· January 2025

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Selective inhibition of HDAC6 by N-acylhydrazone derivative reduces the proliferation and induces senescence in carcinoma hepatocellular cells.
Guilherme Álvaro Ferreira-Silva, Daniel Alencar Rodrigues, Carolina Girotto Pressete, Ester Siqueira Caixeta, Angel Mauricio Castro Gamero, Alexandre Ferro Aissa

Toxicol In Vitro· August 2024

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Loss of STK11 Suppresses Lipid Metabolism and Attenuates KRAS-Induced Immunogenicity in Patients with Non-Small Cell Lung Cancer.
Daniel R Principe, Mary M Pasquinelli, Ryan H Nguyen, Hidayatullah G Munshi, Alicia Hulbert, Alexandre F Aissa

Cancer Res Commun· August 2024

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Antiproliferative Activity of -Acylhydrazone Derivative on Hepatocellular Carcinoma Cells Involves Transcriptional Regulation of Genes Required for G2/M Transition.
Amanda Aparecida Ribeiro Andrade, Fernanda Pauli, Carolina Girotto Pressete, Bruno Zavan, João Adolfo Costa Hanemann, Alexandre Ferro Aissa

Biomedicines· April 2024

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N-acylhydrazone derivative modulates cell cycle regulators promoting mitosis arrest and apoptosis in estrogen positive MCF-7 breast cancer cells.
Melissa Lúcia Melo, Rafael Fonseca, Fernanda Pauli, Bruno Zavan, João Adolfo Costa Hanemann, Alexandre Ferro Aissa

Toxicol In Vitro· December 2023

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Piperine-Chlorogenic Acid Hybrid Inhibits the Proliferation of the SK-MEL-147 Melanoma Cells by Modulating Mitotic Kinases.
Carolina Girotto Pressete, Flávia Pereira Dias Viegas, Thâmara Gaspar Campos, Ester Siqueira Caixeta, João Adolfo Costa Hanemann, Alexandre Ferro Aissa

Pharmaceuticals (Basel)· January 2023

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Diallyl Disulfide Induces Chemosensitization to Sorafenib, Autophagy, and Cell Cycle Arrest and Inhibits Invasion in Hepatocellular Carcinoma.
Ana Rita Thomazela Machado, Katiuska Tuttis, Patrick Wellington da Silva Santos, Alexandre Ferro Aissa, Lusânia Maria Greggi Antunes

Pharmaceutics· November 2022

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Epigenetic changes induced in mice liver by methionine-supplemented and methionine-deficient diets.
Alexandre Ferro Aissa, Volodymyr P Tryndyak, Aline de Conti, Ana Rita Thomazela Machado, Katiuska Tuttis

Food Chem Toxicol· May 2022

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Calcium channel blockers potentiate gemcitabine chemotherapy  in pancreatic cancer.
Daniel R Principe, Alexandre F Aissa, Sandeep Kumar, Thao N D Pham, Patrick W Underwood

Proc Natl Acad Sci U S A· May 2022

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A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis.
Catherine S Blaha, Gopalakrishnan Ramakrishnan, Sang-Min Jeon, Veronique Nogueira, Hyunsoo Rho, Alexandre F Aissa

Nat Commun· February 2022

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A Novel Ruthenium(II) Complex With Lapachol Induces G2/M Phase Arrest Through Aurora-B Kinase Down-Regulation and ROS-Mediated Apoptosis in Human Prostate Adenocarcinoma Cells.
Rone A De Grandis, Katia M Oliveira, Adriana P M Guedes, Patrick W S Dos Santos, Alexandre F Aissa

Front Oncol· June 2021

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Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer.
Alexandre F Aissa, Abul B M M K Islam, Majd M Ariss, Cammille C Go, Alexandra E Rader

Nat Commun· March 2021

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Effects of sulforaphane on the oxidative response, apoptosis, and the transcriptional profile of human stomach mucosa cells in vitro.
Patrick Wellington Santos, Ana Rita Thomazela Machado, Rone De Grandis, Diego Luis Ribeiro, Katiuska Tuttis, Alexandre Ferro Aissa

Mutat Res Genet Toxicol Environ Mutagen· October 2020

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Caffeic acid and chlorogenic acid cytotoxicity, genotoxicity and impact on global DNA methylation in human leukemic cell lines.
Lívia Cristina Hernandes, Ana Rita Thomazela Machado, Katiuska Tuttis, Diego Luís Ribeiro, Alexandre Ferro Aissa

Genet Mol Biol· July 2020

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Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells.
Patrick Wellington da Silva Dos Santos, Ana Rita Thomazela Machado, Rone Aparecido De Grandis, Diego Luis Ribeiro, Katiuska Tuttis, Alexandre Ferro Aissa

Food Chem Toxicol· February 2020

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Analysis of the cytotoxic, genotoxic, mutagenic, and pro-oxidant effect of synephrine, a component of thermogenic supplements, in human hepatic cells in vitro.
Diego Luís Ribeiro, Ana Rita Thomazela Machado, Carla da Silva Machado, Patrick Wellington da Silva Santos, Alexandre Ferro Aissa

Toxicology· June 2019

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Novel lawsone-containing ruthenium(II) complexes: Synthesis, characterization and anticancer activity on 2D and 3D spheroid models of prostate cancer cells.
Rone Aparecido De Grandis, Patrick Wellington da Silva Dos Santos, Katia Mara de Oliveira, Ana Rita Tomazela Machado, Alexandre Ferro Aissa

Bioorg Chem· April 2019

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BjussuLAAO-II induces cytotoxicity and alters DNA methylation of cell-cycle genes in monocultured/co-cultured HepG2 cells.
Ana Rita Thomazela Machado, Alexandre Ferro Aissa, Diego Luis Ribeiro, Rui Seabra Ferreira, Suely Vilela Sampaio

J Venom Anim Toxins Incl Trop Dis· March 2019

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CR-LAAO causes genotoxic damage in HepG2 tumor cells by oxidative stress.
Tássia R Costa, Martin K Amstalden, Diego L Ribeiro, Danilo L Menaldo, Marco A Sartim, Alexandre F Aissa

Toxicology· July 2018

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Methionine-supplemented diet affects the expression of cardiovascular disease-related genes and increases inflammatory cytokines in mice heart and liver.
Alexandre Ferro Aissa, Catia Lira do Amaral, Vinicius Paula Venancio, Carla da Silva Machado, Lívia Cristina Hernandes

J Toxicol Environ Health A· November 2017

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Erythrosine B and quinoline yellow dyes regulate DNA repair gene expression in human HepG2 cells.
Farah Md Chequer, Vinicius P Venancio, Mara R Almeida, Alexandre F Aissa, Maria Lourdes P Bianchi

Toxicol Ind Health· October 2017

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