Publications by authors named "Alexandre Hinzpeter"

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In silico, in vitro and ex vivo characterization of cystic fibrosis transmembrane conductance regulator pathogenic variants localized in the fourth intracellular loop and their rescue by modulators.
Emanuela Pesce, Valeria Tomati, Valeria Capurro, Mariateresa Lena, Cristina Pastorino, Alexandre Hinzpeter

Br J Pharmacol· December 2025

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Beyond Trikafta: new models to assess tissue dependent rescue of N1303K-CFTR.
Iwona Pranke, Valeria Capurro, Benoit Chevalier, Emanuela Pesce, Valeria Tomati, Alexandre Hinzpeter

Front Pharmacol· November 2025

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CFTR correctors potentiate gating mutants causing cystic fibrosis.
Solène Castanier, Ahmad Elbahnsi, Benoit Chevalier, Lynda Berri, Madara Dias Wickramanayaka, Alexandre Hinzpeter

J Cyst Fibros· November 2025

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Investigating of the physico-chemistry thiolated dextran derivatives.
Cléa Chesneau, Andréa Pelletier, Angélique Goffin, Loren Jørgensen, Madara Dias Wickramanayaka, Alexandre Hinzpeter

Colloids Surf B Biointerfaces· July 2025

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Synthesis and physico-chemical investigation of thiolated dextran derivative: Design and application of a redox-responsive drug delivery system.
Cléa Chesneau, Andréa Pelletier, Pierre Dubot, Eric Leroy, Angélique Goffin, Alexandre Hinzpeter

Int J Biol Macromol· March 2025

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TLN468 changes the pattern of tRNA used to read through premature termination codons in CFTR.
Sabrina Karri, David Cornu, Claudia Serot, Lynda Biri, Aurélie Hatton, Alexandre Hinzpeter

J Cyst Fibros· November 2024

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ATP-Binding Cassette and Solute Carrier Transporters: Understanding Their Mechanisms and Drug Modulation Through Structural and Modeling Approaches.
Ahmad Elbahnsi, Balint Dudas, Isabelle Callebaut, Alexandre Hinzpeter, Maria A Miteva

Pharmaceuticals (Basel)· November 2024

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Novel gain-of-function mutants identify a critical region within CFTR membrane-spanning domain 2 controlling cAMP-dependent and ATP-independent channel activation.
Solène Castanier, Ahmad Elbahnsi, Benoit Chevalier, Nesrine Baatallah, Iwona Pranke, Alexandre Hinzpeter

Cell Mol Life Sci· October 2024

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Role of KCNK3 Dysfunction in Dasatinib-associated Pulmonary Arterial Hypertension and Endothelial Cell Dysfunction.
Hélène Le Ribeuz, Anaïs Saint-Martin Willer, Benoit Chevalier, Maria Sancho, Bastien Masson, Alexandre Hinzpeter

Am J Respir Cell Mol Biol· July 2024

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[Therapeutics in cystic fibrosis: Clinical revolution and new challenges].
Emmanuelle Bardin, Iwona Pranke, Alexandre Hinzpeter, Isabelle Sermet-Gaudelus

Med Sci (Paris)· March 2024

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Putting bicarbonate on the spot: pharmacological insights for CFTR correction in the airway epithelium.
Miroslaw Zajac, Agathe Lepissier, Elise Dréano, Benoit Chevalier, Aurélie Hatton, Alexandre Hinzpeter

Front Pharmacol· December 2023

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Nonsense mutations accelerate lung disease and decrease survival of cystic fibrosis children.
Annalisa Orenti, Iwona Pranke, Caroline Faucon, Jessica Varilh, Aurelie Hatton, Alexandre Hinzpeter

J Cyst Fibros· November 2023

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Theratyping cystic fibrosis patients to guide elexacaftor/tezacaftor/ivacaftor out-of-label prescription.
Elise Dreano, Pierre Régis Burgel, Aurelie Hatton, Naim Bouazza, Benoit Chevalier, Alexandre Hinzpeter

Eur Respir J· October 2023

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The U UGA C sequence provides a favorable context to ELX-02 induced CFTR readthrough.
Iwona M Pranke, Jessica Varilh, Aurélie Hatton, Caroline Faucon, Emmanuelle Girodon, Alexandre Hinzpeter

J Cyst Fibros· May 2023

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Design of Crotoxin-Based Peptides with Potentiator Activity Targeting the ΔF508NBD1 Cystic Fibrosis Transmembrane Conductance Regulator.
Marc Ravatin, Norbert Odolczyk, Nathalie Servel, J Iñaki Guijarro, Eric Tagat, Alexandre Hinzpeter

J Mol Biol· February 2023

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Elexacaftor/Tezacaftor/Ivacaftor Disrupts Respiratory Tract Development in a Murine Fetal Lung Explant Model.
Mickaël Lhuillier, Laura Aoust, Elise Dreano, Marie-Laure Franco-Montoya, Kim Landry-Truchon, Alexandre Hinzpeter

Am J Respir Cell Mol Biol· December 2022

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Acting on the CFTR Membrane-Spanning Domains Interface Rescues Some Misfolded Mutants.
Nesrine Baatallah, Ahmad Elbahnsi, Benoit Chevalier, Solène Castanier, Jean-Paul Mornon, Alexandre Hinzpeter

Int J Mol Sci· December 2022

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Keratin 8 is a scaffolding and regulatory protein of ERAD complexes.
Iwona Maria Pranke, Benoit Chevalier, Aiswarya Premchandar, Nesrine Baatallah, Kamil F Tomaszewski, Alexandre Hinzpeter

Cell Mol Life Sci· September 2022

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Pharmacological chaperone-rescued cystic fibrosis CFTR-F508del mutant overcomes PRAF2-gated access to endoplasmic reticulum exit sites.
Kusumika Saha, Benoit Chevalier, Stéphane Doly, Nesrine Baatallah, Thomas Guilbert, Alexandre Hinzpeter

Cell Mol Life Sci· September 2022

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Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters.
Benoît Chevalier, Nesrine Baatallah, Matthieu Najm, Solène Castanier, Vincent Jung, Alexandre Hinzpeter

Int J Mol Sci· August 2022

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Reclassifying inconclusive diagnosis after newborn screening for cystic fibrosis. Moving forward.
Aurelie Hatton, Anne Bergougnoux, Katarzyna Zybert, Benoit Chevalier, Myriam Mesbahi, Alexandre Hinzpeter

J Cyst Fibros· May 2022

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Systemic bis-phosphinic acid derivative restores chloride transport in Cystic Fibrosis mice.
Mélanie Faria da Cunha, Iwona Pranke, Ali Sassi, Christiane Schreiweis, Stéphanie Moriceau, Alexandre Hinzpeter

Sci Rep· April 2022

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Correlating genotype with phenotype using CFTR-mediated whole-cell Cl currents in human nasal epithelial cells.
Sabrina Noel, Nathalie Servel, Aurélie Hatton, Anita Golec, Mayuree Rodrat, Alexandre Hinzpeter

J Physiol· March 2022

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Pharmacological chaperones improve intra-domain stability and inter-domain assembly via distinct binding sites to rescue misfolded CFTR.
Nesrine Baatallah, Ahmad Elbahnsi, Jean-Paul Mornon, Benoit Chevalier, Iwona Pranke, Alexandre Hinzpeter

Cell Mol Life Sci· December 2021

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Author Correction: New insights into structure and function of bis-phosphinic acid derivatives and implications for CFTR modulation.
Sara Bitam, Ahmad Elbahnsi, Geordie Creste, Iwona Pranke, Benoit Chevalier, Alexandre Hinzpeter

Sci Rep· September 2021

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