Publications by authors named "Alexandre Wohlkonig"

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Correction: A nanobody-based microfluidic chip for fast and automated purification of protein complexes.
Phebe De Keyser, Mitch de Waard, Ignaas S M Jimidar, Sandrien Verloy, Steven Janvier

Lab Chip· October 2025

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A biosensor-based phage display selection method for automated, high-throughput Nanobody discovery.
Phebe De Keyser, Valentina Kalichuk, Thomas Zögg, Alexandre Wohlkönig, Stephan Schenck

Biosens Bioelectron· March 2025

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A nanobody-based microfluidic chip for fast and automated purification of protein complexes.
Phebe De Keyser, Mitch de Waard, Ignaas S M Jimidar, Sandrien Verloy, Steven Janvier

Lab Chip· December 2024

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Domain architecture of the MabR (), a member of the PucR transcription factor family.
Véronique Megalizzi, Abdalkarim Tanina, Camille Grosse, Manon Mirgaux, Pierre Legrand

Heliyon· November 2024

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Allosteric nanobodies to study the interactions between SOS1 and RAS.
Baptiste Fischer, Tomasz Uchański, Aidana Sheryazdanova, Simon Gonzalez, Alexander N Volkov

Nat Commun· July 2024

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Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Kevin Van Holsbeeck, Baptiste Fischer, Simon Gonzalez, Charlène Gadais, Wim Versées

Angew Chem Int Ed Engl· June 2023

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Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM.
Tomasz Uchański, Simonas Masiulis, Baptiste Fischer, Valentina Kalichuk, Uriel López-Sánchez

Nat Methods· January 2021

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Fragment-Based Optimized EthR Inhibitors with Ethionamide Boosting Activity.
Baptiste Villemagne, Arnaud Machelart, Ngoc Chau Tran, Marion Flipo, Martin Moune

ACS Infect Dis· March 2020

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Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1.
Levi J McClelland, Kaiming Zhang, Tung-Chung Mou, Jake Johnston, Cindee Yates-Hansen, Alexandre Wohlkonig

Nat Commun· February 2020

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Methyl arachidonyl fluorophosphonate inhibits Mycobacterium tuberculosis thioesterase TesA and globally affects vancomycin susceptibility.
Dong Yang, Guy Vandenbussche, Didier Vertommen, Damien Evrard, Romany Abskharon

FEBS Lett· January 2020

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Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion.
Romany Abskharon, Fei Wang, Alexandre Wohlkonig, Juxin Ruan, Sameh Soror

PLoS Pathog· December 2019

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A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2.
Hugues Prevet, Martin Moune, Abdalkarim Tanina, Christian Kemmer, Adrien Herledan

Eur J Med Chem· April 2019

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A comprehensive analysis of the protein-ligand interactions in crystal structures of Mycobacterium tuberculosis EthR.
Abdalkarim Tanina, Alexandre Wohlkönig, Sameh H Soror, Marion Flipo, Baptiste Villemagne

Biochim Biophys Acta Proteins Proteom· March 2019

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An improved yeast surface display platform for the screening of nanobody immune libraries.
Tomasz Uchański, Thomas Zögg, Jie Yin, Daopeng Yuan, Alexandre Wohlkönig

Sci Rep· January 2019

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Correction to Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2- a]pyridine Series of Autotaxin Inhibitors.
Agnès Joncour, Nicolas Desroy, Christopher Housseman, Xavier Bock, Natacha Bienvenu, Alexandre Wohlkonig

J Med Chem· May 2018

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Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviors.
Romany Abskharon, Johnny Dang, Ameer Elfarash, Zerui Wang, Pingping Shen, Alexandre Wohlkonig

Microb Cell Fact· October 2017

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Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors.
Agnès Joncour, Nicolas Desroy, Christopher Housseman, Xavier Bock, Natacha Bienvenu, Alexandre Wohlkonig

J Med Chem· September 2017

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Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2.
Alexandre Wohlkönig, Han Remaut, Martin Moune, Abdalkarim Tanina, Franck Meyer

Biochem Biophys Res Commun· May 2017

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Reversion of antibiotic resistance in by spiroisoxazoline SMARt-420.
Nicolas Blondiaux, Martin Moune, Matthieu Desroses, Rosangela Frita, Marion Flipo

Science· March 2017

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Quiescin-sulfhydryl oxidase inhibits prion formation .
Yi-An Zhan, Romany Abskharon, Yu Li, Jue Yuan, Liang Zeng, Alexandre Wohlkonig

Aging (Albany NY)· December 2016

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Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide.
Velupillai Srikannathasan, Alexandre Wohlkonig, Anthony Shillings, Onkar Singh, Pan F Chan

Acta Crystallogr F Struct Biol Commun· October 2015

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Production, crystallization and preliminary X-ray diffraction of the Gαs α-helical domain in complex with a nanobody.
Sarah Triest, Alexandre Wohlkönig, Els Pardon, Jan Steyaert

Acta Crystallogr F Struct Biol Commun· November 2014

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Ligand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches.
Baptiste Villemagne, Marion Flipo, Nicolas Blondiaux, Céline Crauste, Sandra Malaquin

J Med Chem· June 2014

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The Mycobacterium tuberculosis transcriptional repressor EthR is negatively regulated by Serine/Threonine phosphorylation.
Jade Leiba, Séverine Carrère-Kremer, Nicolas Blondiaux, Martin Moune Dimala, Alexandre Wohlkönig

Biochem Biophys Res Commun· April 2014

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A general protocol for the generation of Nanobodies for structural biology.
Els Pardon, Toon Laeremans, Sarah Triest, Søren G F Rasmussen, Alexandre Wohlkönig

Nat Protoc· March 2014

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